Motor evoked potentials in clinically isolated syndrome suggestive of multiple sclerosis

2009 ◽  
Vol 15 (3) ◽  
pp. 355-362 ◽  
Author(s):  
A Rico ◽  
B Audoin ◽  
J Franques ◽  
A Eusebio ◽  
F Reuter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Amplitude Ratio ◽  
Motor Evoked Potentials ◽  
Clinically Isolated Syndrome ◽  
Conduction Time ◽  
Motor Pathway ◽  
Clinical Sensitivity ◽  
Conduction Failure ◽  
Stimulation Technique

The aim of the present study was to determine the sensitivity and the profile of motor evoked potentials (MEP) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). We measured the central motor conduction time (CMCT), amplitude ratio (AR), and surface ratio (SR) in tibialis anterior and first dorsal interosseous muscles in 22 patients with CIS. In 12 patients, the triple stimulation technique (TST) was also performed. AR was abnormal in 50% of patients, CMCT in 18% of patients, and TST in 25% of patients. AR had the highest sub-clinical sensitivity and the best positive predictive value. In the absence of clinical pyramidal signs, an early AR decrease seems to result from demyelination inducing excessive temporal dispersion of the MEP, while in territories with clinical pyramidal signs, it seems to result from conduction failure, which suggests that clinical pyramidal signs may be attributable to conduction failure. This study demonstrates that MEP, especially the AR, is sensitive to motor pathway dysfunction right from the early stages of MS.

Is the triple stimulation technique a better quantification tool of motor dysfunction than motor evoked potentials in multiple sclerosis?

2018 ◽  
Vol 119 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Xavier Giffroy ◽  
Dominique Dive ◽  
Jean-François Kaux ◽  
Nathalie Maes ◽  
Adelin Albert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Motor Dysfunction ◽  
Stimulation Technique ◽  
Triple Stimulation Technique

scholarly journals Physiotherapy Approaches in the Treatment of Ataxic Multiple Sclerosis: A Pilot Study

2001 ◽  
Vol 15 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Kadriye Armutlu ◽  
Rana Karabudak ◽  
Gülay Nurlu
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Control Group ◽  
Study Group ◽  
Conduction Time ◽  
Expanded Disability Status Scale ◽  
Gait Parameters ◽  
Significant Difference ◽  
Disability Status

Objective: This study was planned to investigate the efficacy of neuromuscular rehabilitation and Johnstone Pressure Splints in the patients who had ataxic multiple sclerosis. Methods: Twenty-six outpatients with multiple sclerosis were the subjects of the study. The control group (n = 13) was given neuromuscular rehabilitation, whereas the study group (n = 13) was treated with Johnstone Pressure Splints in ad dition. Results: In pre- and posttreatment data, significant differences were found in sensation, anterior balance, gait parameters, and Expanded Disability Status Scale (p < 0.05). An important difference was observed in walking-on-two-lines data within the groups (p < 0.05). There also was a statistically significant difference in pendular movements and dysdiadakokinesia (p < 0.05). When the posttreatment values were compared, there was no significant difference between sensation, anterior balance, gait parameters, equilibrium and nonequilibrium coordination tests, Expanded Disability Status Scale, cortical onset latency, and central conduction time of somatosensory evoked potentials and motor evoked potentials (p > 0.05). Comparison of values re vealed an important difference in cortical onset-P37 peak amplitude of somatosen sory evoked potentials (right limbs) in favor of the study group (p < 0.05). Conclu sions : According to our study, it was determined that physiotherapy approaches were effective to decrease the ataxia. We conclude that the combination of suitable phys iotherapy techniques is effective multiple sclerosis rehabilitation. Key Words: Multi ple sclerosis—Ataxia—Physical therapy.

Motor evoked potentials in multiple sclerosis patients without walking limitation: amplitude vs. conduction time abnormalities

2007 ◽  
Vol 254 (2) ◽  
pp. 220-227 ◽  
Author(s):  
Andrea Gagliardo ◽  
Francesca Galli ◽  
Antonello Grippo ◽  
Aldo Amantini ◽  
Cristiana Martinelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Conduction Time ◽  
Multiple Sclerosis Patients

scholarly journals Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis—An Explorative Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Sepehr Mamoei ◽  
Henrik Boye Jensen ◽  
Andreas Kristian Pedersen ◽  
Mikkel Karl Emil Nygaard ◽  
Simon Fristed Eskildsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Longitudinal Study ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Motor Evoked Potentials ◽  
Step Test ◽  
Conduction Time ◽  
Lesion Load ◽  
Clinical Trial Registration ◽  
Peripheral Motor

Objective: Persons with multiple sclerosis (PwMS), already established as responders or non-responders to Fampridine treatment, were compared in terms of disability measures, physical and cognitive performance tests, neurophysiology, and magnetic resonance imaging (MRI) outcomes in a 1-year explorative longitudinal study.Materials and Methods: Data from a 1-year longitudinal study were analyzed. Examinations consisted of the timed 25-foot walk test (T25FW), six spot step test (SSST), nine-hole peg test (9-HPT), five times sit-to-stand test (5-STS), symbol digit modalities test (SDMT), transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEP) examining central motor conduction times (CMCT), peripheral motor conduction times (PMCT) and their amplitudes, electroneuronography (ENG) of the lower extremities, and brain structural MRI measures.Results: Forty-one responders and eight non-responders to Fampridine treatment were examined. There were no intergroup differences except for the PMCT, where non-responders had prolonged conduction times compared to responders to Fampridine. Six spot step test was associated with CMCT throughout the study. After 1 year, CMCT was further prolonged and cortical MEP amplitudes decreased in both groups, while PMCT and ENG did not change. Throughout the study, CMCT was associated with the expanded disability status scale (EDSS) and 12-item multiple sclerosis walking scale (MSWS-12), while SDMT was associated with number of T2-weighted lesions, lesion load, and lesion load normalized to brain volume.Conclusions: Peripheral motor conduction time is prolonged in non-responders to Fampridine when compared to responders. Transcranial magnetic stimulation-elicited MEPs and SDMT can be used as markers of disability progression and lesion activity visualized by MRI, respectively.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03401307.

Motor evoked potentials in a mouse model of chronic multiple sclerosis

2006 ◽  
Vol 33 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Stefano Amadio ◽  
Stefano Pluchino ◽  
Elena Brini ◽  
Paolo Morana ◽  
Roberta Guerriero ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mouse Model ◽  
Evoked Potentials ◽  
Motor Evoked Potentials

Natalizumab restores evoked potential abnormalities in patients with relapsing–remitting multiple sclerosis

2010 ◽  
Vol 17 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Sven G Meuth ◽  
Stefan Bittner ◽  
Carola Seiler ◽  
Kerstin Göbel ◽  
Heinz Wiendl
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Sum Score ◽  
Relapsing Remitting ◽  
Natalizumab Treatment ◽  
Remitting Multiple Sclerosis ◽  
Sum Scores ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

Background and Objective: The objective of this study was to examine the effects of natalizumab on functional parameters assessed by evoked potentials (visual [VEP], somatosensory [SEP] and motor evoked potentials [MEP]) in a cohort study in relapsing–remitting multiple sclerosis patients. Methods: EP data of 44 patients examined 12 months prior to natalizumab treatment, at the timepoint of treatment initiation and 1 year later were compared. Sum scores (VEP, MEP, SEP) were evaluated and correlated with the Expanded Disability Status Scale. Results: Improvement of the VEP sum score was found in 33% of natalizumab-treated patients but only in 9% of the same patients prior to treatment ( p = 0.041). A comparable situation was found for SEP (improvement: 32% versus 5%; worsening: 11% versus 37%; p = 0.027). For MEP no significant differences were seen (improvement: 10% versus 18%; worsening: 5% versus 29%; p = 0.60). EP recordings (VEP = SEP > MEP) have the capacity to demonstrate treatment effects of natalizumab on a functional level. Conclusions: Natalizumab therapy increases the percentage of patients showing stable or even ameliorated electrophysiological parameters in the investigated functional systems.

Improvement in motor evoked potentials and clinical course post-steroid therapy in multiple sclerosis

1992 ◽  
Vol 108 (2) ◽  
pp. 184-188 ◽  
Author(s):  
J.Y. Salle ◽  
J. Hugon ◽  
F. Tabaraud ◽  
J.M. Boulesteix ◽  
J.M. Vallat ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Steroid Therapy ◽  
Clinical Course ◽  
Motor Evoked Potentials

The size of motor-evoked potentials: influencing parameters and quantification

2012 ◽  
Author(s):  
Kai M. Rösler ◽  
Michel R. Magistris
Keyword(s):  
Evoked Potentials ◽  
Motor Neurons ◽  
Healthy Subjects ◽  
Motor Evoked Potentials ◽  
Conduction Block ◽  
Phase Cancellation ◽  
Pathological Conditions ◽  
The Central Nervous System ◽  
Stimulation Technique ◽  
Triple Stimulation Technique

This article discusses parameters influencing the size of motor-evoked potentials (MEPs) in normal and pathological conditions, and the methods of meaningful quantification of the MEPs. MEPs are widely used to study the physiology of corticospinal conduction in healthy subjects and in patients with diseases of the central nervous system. The characteristics of MEP size are, stimulus intensity, coil positioning, and facilitation. MEPs show variability in size and shape from one stimulus to the next, even if the stimulus parameters are kept constant. This article describes the triple stimulation technique (TST), which was developed to eliminate the effects of phase cancellation from the MEPs, to allow for a better quantification. Pathological conditions may modify the parameters discussed in the article and influence the size of the MEPs by lesions of motor neurons or of their axons, central conduction velocity slowing, or conduction block.

scholarly journals Cortical Relay Time for Long Latency Reflexes in Patients with Definite Multiple Sclerosis

2004 ◽  
Vol 31 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Cengiz Tataroglu ◽  
Ahmet Genc ◽  
Egemen Idiman ◽  
Raif Cakmur ◽  
Fethi Idiman
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Clinical Form ◽  
Control Subjects ◽  
Long Latency ◽  
Cortical Involvement ◽  
And Control ◽  
Long Latency Reflexes

AbstractBackground:Long latency reflexes (LLR) include afferent sensory, efferent motor and central transcortical pathways. It is supposed that the cortical relay time (CRT) reflects the conduction of central transcortical loop of LLR. Recently, evidence related to the cortical involvement in multiple sclerosis (MS) has been reported in some studies. Our aim was to investigate the CRT alterations in patients with MS.Methods:Upper extremity motor evoked potentials (MEP), somatosensory evoked potentials (SEP) and LLR were tested in 28 patients with MS and control subjects (n=22). The patients with MS were classified according to the clinical form (relapsing-remitting [R-R] and progressive groups). The MS patients with secondary progressive and primary progressive forms were considered as the “progressive” group. CRT for LLR was calculated by subtracting the peak latency of somatosensory evoked potentials (SEP) and that of motor evoked potentials (MEP) by transcranial magnetic stimulation from the onset latency of the second component of LLR (LLR2) (CRT = LLR2 – [MEP latency + N20 latency])Results:Cortical relay time was calculated as 7.4 ± 0.9 ms in control subjects. Cortical relay time was prolonged in patients with MS (11.2 ± 2.9 ms) (p<0.0001). The latencies of LLR, MEP and SEP were also prolonged in patients with MS. Cortical relay time was not correlated with disease severity and clinical form in contrast to other tests.Conclusions:Our findings suggested that CRT can be a valuable electrophysiological tool in patients with MS. Involvement of extracortical neural circuits between sensory and motor cortices or cortical involvement due to MS may cause these findings.

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