Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative

White matter hyperintensities are frequently detected on cranial magnetic resonance imaging (MRI) scans of older adults. Given the presumed ischemic contribution to the etiology of these lesions and the posited import of resting brain activity on cognitive function, we hypothesized that longitudinal changes in MRI-detected white matter disease, and its severity at a given time point, would be associated with changes in regional cerebral blood flow (rCBF) over time. We evaluated MRI scans and resting H215O positron emission tomographic rCBF at baseline and after an average of 7.7-year follow-up in Baltimore Longitudinal Study of Aging participants without dementia. Differences in patterns of rCBF were evident at baseline and at follow-up between the group of subjects showing increased white matter disease over the 8-year interval compared with the group with stable white matter ratings. Furthermore, longitudinal changes over time in rCBF also differed between the two groups. Specifically, the group with progressive white matter abnormalities showed greater increase in the right inferior temporal gyrus/fusiform gyrus, right anterior cingulate, and the rostral aspect of the left superior temporal gyrus. Regions of greater longitudinal decrease in this group were evident in the right inferior parietal lobule and at the right occipital pole. Changes in white matter disease over time and its severity at any given time are associated significantly with both cross-sectional and longitudinal patterns of rCBF. The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration.

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O5-04-06: Longitudinal changes in white matter disease and cognition in subcortical vascular mild cognitive impairment

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.04.492 ◽

2013 ◽

Vol 9 ◽

pp. P837-P837

Author(s):

Hee-Jin Kim ◽

Young Noh ◽

Hanna Cho ◽

Cindy Yoon ◽

Byoung Seok Ye ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

White Matter Disease ◽

Longitudinal Changes

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Longitudinal changes in advanced diffusion MRI of normal-appearing white matter and chronic lesions in ocrelizumab treated relapsing MS

10.26226/morressier.5b719e455aff74008ae4c9ed ◽

2018 ◽

Author(s):

Anika Wurl ◽

Irene M. Vavasour

Keyword(s):

White Matter ◽

Diffusion Mri ◽

Longitudinal Changes ◽

Normal Appearing White Matter

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Faculty Opinions recommendation of Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717965007.793466165 ◽

2012 ◽

Author(s):

Jean-François Dartigues ◽

Alexandra Foubert

Keyword(s):

White Matter ◽

Alzheimer Disease ◽

White Matter Hyperintensity ◽

Hippocampal Atrophy

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Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease

Current Alzheimer Research ◽

10.2174/1567205015666181002141013 ◽

2018 ◽

Vol 15 (14) ◽

pp. 1354-1360 ◽

Cited By ~ 4

Author(s):

Ping-Song Chou ◽

Yi-Hui Kao ◽

Meng-Ni Wu ◽

Mei-Chuan Chou ◽

Chun-Hung Chen ◽

...

Keyword(s):

White Matter ◽

Alzheimer Disease ◽

Rating Scale ◽

Vital Role ◽

Independent Effect ◽

Cerebral White Matter ◽

Clinical Dementia Rating ◽

White Matter Changes ◽

Age Related ◽

The Mean

Background: Cerebrovascular pathologies and hypertension could play a vital role in Alzheimer disease (AD) progression. However, whether cerebrovascular pathologies and hypertension accelerate the AD progression through an independent or interaction effect is unknown. Objective: To investigate the effect of the interactions of cerebrovascular pathologies and hypertension on AD progression. Method: A retrospective longitudinal study was conducted to compare AD courses in patients with different severities of cerebral White Matter Changes (WMCs) in relation to hypertension. Annual comprehensive psychometrics were performed. WMCs were rated using a rating scale for Age-related WMCs (ARWMC). Results: In total, 278 patients with sporadic AD were enrolled in this study. The mean age of the patients was 76.6 ± 7.4 years, and 166 patients had hypertension. Among AD patients with hypertension, those with deterioration in clinical dementia rating-sum of box (CDR-SB) and CDR had significantly severe baseline ARWMC scales in total (CDR-SB: 5.8 vs. 3.6, adjusted P = 0.04; CDR: 6.4 vs. 4.4, adjusted P = 0.04) and frontal area (CDR-SB: 2.4 vs. 1.2, adjusted P = 0.01; CDR: 2.4 vs. 1.7, adjusted P < 0.01) compared with those with no deterioration in psychometrics after adjustment for confounders. By contrast, among AD patients without hypertension, no significant differences in ARWMC scales were observed between patients with and without deterioration. Conclusion: The effect of cerebrovascular pathologies on AD progression between those with and without hypertension might differ. An interaction but not independent effect of hypertension and WMCs on the progression of AD is possible.

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