Interactions betweenRAD51rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate

2015 ◽  
Vol 170 (2) ◽  
pp. 536-539 ◽  
Author(s):  
Renato Assis Machado ◽  
Helenara Salvati Bertolossi Moreira ◽  
Sibele Nascimento de Aquino ◽  
Hercilio Martelli-Junior ◽  
Silvia Regina de Almeida Reis ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cigarette Smoking ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Maternal Cigarette Smoking

scholarly journals Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs

BMC Medicine ◽  
2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Lili Yang ◽  
Huan Wang ◽  
Liu Yang ◽  
Min Zhao ◽  
Yajun Guo ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Cleft Palate ◽  
Congenital Anomalies ◽  
Maternal Smoking ◽  
Cleft Lip ◽  
First Trimester ◽  
Vital Statistics ◽  
Third Trimester ◽  
Maternal Cigarette Smoking ◽  
Increased Risk

Abstract Background The associations of maternal cigarette smoking with congenital anomalies in offspring have been inconsistent. This study aimed to clarify the associations of the timing and intensity of maternal cigarette smoking with 12 subtypes of birth congenital anomalies based on a nationwide large birth cohort in the USA. Methods We used nationwide birth certificate data from the US National Vital Statistics System during 2016–2019. Women reported the average daily number of cigarettes they consumed 3 months before pregnancy and in each subsequent trimester during pregnancy. Twelve subtypes of congenital anomalies were identified in medical records. Poisson regression analysis was used to estimate the risk ratios (RRs) with 95% confidence intervals (CIs) for 12 subtypes of congenital anomalies associated with the timing (i.e., before pregnancy, and during three different trimesters of pregnancy) and intensity (i.e., number of cigarettes consumed per day) of maternal cigarette smoking. Results Among the 12,144,972 women included, 9.3% smoked before pregnancy and 7.0%, 6.0%, and 5.7% in the first, second, and third trimester, respectively. Maternal smoking before or during pregnancy significantly increased the risk of six subtypes of birth congenital anomalies (i.e., congenital diaphragmatic hernia, gastroschisis, limb reduction defect, cleft lip with or without cleft palate, cleft palate alone, and hypospadias), even as low as 1–5 cigarettes per day. The adjusted RRs (95% CIs) for overall birth congenital anomalies (defined as having any one of the congenital malformations above significantly associated with maternal cigarette smoking) among women who smoked 1–5, 6–10, and ≥ 11 cigarettes per day before pregnancy were 1.31 (1.22–1.41), 1.25 (1.17–1.33), and 1.35 (1.28–1.43), respectively. Corresponding values were 1.23 (1.14–1.33), 1.33 (1.24–1.42), 1.33 (1.23–1.43), respectively, for women who smoked cigarettes in the first trimester; 1.32 (1.21–1.44), 1.36 (1.26–1.47), and 1.38 (1.23–1.54), respectively, for women who smoked cigarettes in the second trimester; and 1.33 (1.22–1.44), 1.35 (1.24–1.47), and 1.35 (1.19–1.52), respectively, for women who smoked cigarettes in the third trimester. Compared with women who kept smoking before and throughout pregnancy, women who never smoked had significantly lower risk of congenital anomalies (RR 0.77, 95% CI 0.73–0.81), but women who smoked before pregnancy and quitted during each trimester of pregnancy had no reduced risk (all P > 0.05). Conclusions Maternal smoking before or during pregnancy increased the risk of several birth congenital anomalies, even as low as 1–5 cigarettes per day. Maternal smokers who stopped smoking in the subsequent trimesters of pregnancy were still at an increased risk of birth congenital anomalies. Our findings highlighted that smoking cessation interventions should be implemented before pregnancy.

Maternal Cigarette Smoking and Oral Clefts: A Meta-analysis

1997 ◽  
Vol 34 (3) ◽  
pp. 206-210 ◽  
Author(s):  
Diego F. Wyszynski ◽  
David L. Duffy ◽  
Terri H. Beaty
Keyword(s):  
Cigarette Smoking ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Meta Analysis ◽  
First Trimester ◽  
Case Control Studies ◽  
Oral Clefts ◽  
Oral Cleft ◽  
Maternal Cigarette Smoking ◽  
Increased Risk

Objective A meta-analysis was performed to estimate the association between maternal cigarette smoking and the risk of having a child with a nonsyndromic oral cleft (NSOC). Design Studies published from 1966 through 1996 were retrieved using MEDLINE, Current Contents, bibliographies, and other sources. MEDLINE and Current Contents search terms included “oral clefts,” “cigarette smoking,” “birth defects,” and “congenital malformations.” Cohort and case-control studies that enrolled oral cleft patients [cleft lip with or without cleft palate (CL/P), cleft palate (CP), or both] and controls, and presented information on maternal cigarette exposure during pregnancy were included in the analysis. Descriptive and outcome data from each study were independently abstracted by two authors. Results The overall odds ratio of the 11 studies satisfying criteria was 1.29 [95% confidence interval (CI), 1.18 to 1.42] for CL/P and 1.32 (95% CI: 1.10 to 1.62) for CP, Indicating a small increased risk of having a child with either a CL/P or a CP for mothers who smoke during the first trimester of the pregnancy. Conclusions These analyses suggest a small but statistically significant association between maternal cigarette smoking during the first trimester of gestation and increased risk of having a child with a CL/P or CP.

rs1801133C>T polymorphism inMTHFRis a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population

2015 ◽  
Vol 103 (4) ◽  
pp. 292-298 ◽  
Author(s):  
Pamella Kelly Farias de Aguiar ◽  
Ricardo D. Coletta ◽  
Allane Maria Lacerda Ferreira de Oliveira ◽  
Renato Assis Machado ◽  
Paulo Germano Cavalcante Furtado ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Brazilian Population

Short mandible - a possible risk factor for cleft palate with/without a cleft lip

2014 ◽  
Vol 17 (2) ◽  
pp. 106-114 ◽  
Author(s):  
N. V. Hermann ◽  
T. A. Darvann ◽  
B. K. Ersbøll ◽  
S. Kreiborg
Keyword(s):  
Risk Factor ◽  
Cleft Palate ◽  
Cleft Lip

Infant TGF-Alpha Genotype, Orofacial Clefts, and Maternal Periconceptional Multivitamin Use

1998 ◽  
Vol 35 (4) ◽  
pp. 366-370 ◽  
Author(s):  
Gary M. Shaw ◽  
Cathy R. Wasserman ◽  
Jeffrey C. Murray ◽  
Edward J. Lammer
Keyword(s):  
Cigarette Smoking ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Strong Association ◽  
Preliminary Evidence ◽  
Serum Folate ◽  
Orofacial Cleft ◽  
Orofacial Clefts ◽  
Multivitamin Use

Objective We previously demonstrated a strong association between periconceptional maternal cigarette smoking, infant transforming growth factor–alpha (TGFa) genotype, and risk of orofacial clefts. Because serum folate may be decreased by cigarette smoking and because maternal periconceptional use of multivitamins containing folic acid has been associated with a reduced risk of clefting, we explored whether a potential relation existed between infant TGFa genotype, maternal multivitamin use, and risk of orofacial cleft phenotypes. Design Data were derived from a population-based case–control study of fetuses and live-born infants among a cohort of 1987 to 1989 California births (n = 548,844). Information concerning periconceptional multivitamin use was obtained via telephone interviews with mothers of 731 (84.7% of eligible) orofacial cleft case infants, and of 734 (78.2%) nonmalformed control infants. DNA was obtained from newborn screening bloodspots and genotyped for the Taq1 polymorphism of TGFa. Among infants of interviewed mothers, genotypes were available for 571 (78.1%) case infants and 640 (87.2%) control infants. Setting The study encompassed all hospitals in selected California counties. Main Outcome Measure The main outcome measures were the risks of specific cleft phenotypes among infants with uncommon TGFa genotypes and whose mothers did not use multivitamins periconceptionally. Results Compared with infants homozygous for the common TGFa genotype and whose mothers used multivitamins, increased clefting risks were observed for infants with the A2 genotype (homozygous or heterozygous) and whose mothers did not use multivitamins. Risk estimates were 3.0 (1.4–6.6 [95% confidence interval]) for isolated cleft lip with or without cleft palate (CLP), 2.4 (0.69–11.6) for multiple CLP, 2.6 (0.97–7.7) for isolated cleft palate (CP), 4.2 (1.3–16.2) for multiple CP, and 8.1 (2.6–27.7) for “known-syndrome” clefts. Clefting risks for infants with the A2 genotype and whose mothers used multivitamins were substantially smaller, as were the risks for infants with the A1 genotype whose mothers did not use multivitamins. Conclusion These data provide preliminary evidence for a gene–nutrient interaction in risk of clefting.

MTHFRc.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile

Oral Diseases ◽  
2016 ◽  
Vol 22 (7) ◽  
pp. 703-708 ◽  
Author(s):  
C Ramírez-Chau ◽  
R Blanco ◽  
A Colombo ◽  
R Pardo ◽  
J Suazo
Keyword(s):  
Risk Factor ◽  
Cleft Palate ◽  
Cleft Lip
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