AN UNUSUAL ALTERATION IN THE NATURAL HISTORY OF A GIANT CELL TUMOR OF BONE

Shoulder metallosis with giant cell tumor formation is rarely seen in shoulder surgery. With an increase in shoulder arthroplasty and complex revision shoulder surgeries, clinicians should have an index of suspicion for possible metallosis in patients that presents with unexplained persistent pain with metal components on both the glenoid and humeral side. This case describes a 43-yearold female with a history of six prior shoulder surgeries who presented with shoulder metallosis and giant cell tumor formation after a screw from her open Latarjet procedure began rubbing against her Hemicap implant. She successfully underwent a revision total shoulder arthroplasty for post traumatic arthritis with pectoralis major transfer for her chronic subscapularis rupture and had complete symptom resolution.

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Tumor-Like Reaction to Polypropylene Mesh from a Mid-Urethral Sling Material Resembling Giant Cell Tumor of Vagina

Case Reports in Obstetrics and Gynecology ◽

10.1155/2017/6701643 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Ali Azadi ◽

James A. Bradley ◽

Dennis M. O’Connor ◽

Amir Azadi ◽

Donald R. Ostergard

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Vaginal Wall ◽

Anterior Vaginal Wall ◽

Tumor Formation ◽

Cell Tumor ◽

Pathological Analysis ◽

Carcinogenic Potential ◽

Polypropylene Material ◽

History Of

Background. Polypropylene material is widely used in gynecological surgery. There are few reports regarding its carcinogenic potential. There is lack of evidence supporting tumor formation directly attributed to the use of polypropylene material. Case. This patient is a 49-year-old woman with a history of stress urinary incontinence which required a MiniArc® Sling who presented with a hard, tender, immobile mass on the anterior vaginal wall. Pathological analysis of the mass revealed a tumor-like reaction to the polypropylene material that resembled a giant cell tumor of soft tissue. Conclusion. The use of polypropylene in surgery is ubiquitous across disciplines; thus consideration for a tumor-like reaction to the material should exist for patients who present with a mass near the surgical site.

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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab

Case Reports in Medicine ◽

10.1155/2015/767198 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 25

Author(s):

Cory Julian Broehm ◽

Erika L. Garbrecht ◽

Jeff Wood ◽

Therese Bocklage

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Malignant Transformation ◽

Radiation Treatment ◽

Cell Tumor ◽

Rank Ligand ◽

Review Of The Literature ◽

Sarcomatous Transformation ◽

History Of ◽

Multiple Recurrences

Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence. Sarcomatous transformation is rare and typically occurs with a history of recurrences and radiation treatment. Denosumab, an inhibitor of the RANK ligand involved in bone resorption in GCT, is increasingly used in treatment of recurrent or unresectable giant cell tumor of bone. We report two cases of sarcomatous transformation of GCT to osteosarcoma in patients receiving denosumab. One was a 59-year-old male with a 12-year history of GCT and multiple recurrences taking denosumab for 2.5 years. The second case was in a 56-year-old male with a seven-year history of GCT taking denosumab for six months. Review of the literature shows one case report of malignant transformation of GCT in a patient being treated with denosumab. As the use of denosumab for treatment of GCT will likely increase, larger, controlled studies are needed to ascertain whether denosumab may play a role in malignant transformation of giant cell tumor of bone.

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Multicentric Giant Cell Tumor of Bone: Synchronous and Metachronous Presentation

Case Reports in Orthopedics ◽

10.1155/2013/756723 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Reiner Wirbel ◽

Frank Blümler ◽

Dirk Lommel ◽

Guido Syré ◽

Veit Krenn

Keyword(s):

Magnetic Resonance ◽

Literature Review ◽

Giant Cell Tumor ◽

Giant Cell ◽

Proximal Femur ◽

Proximal Humerus ◽

Distal Tibia ◽

Cell Tumor ◽

History Of ◽

The Right

A 27-year-old man treated 2.5 years ago for synchronous multicentric giant cell tumor of bone located at the right proximal humerus and the right 5th finger presented now with complaints of pain in his right hip and wrist of two-month duration. Radiology and magnetic resonance revealed multicentric giant cell tumor lesions of the right proximal femur, the left ileum, the right distal radius, and the left distal tibia. The patient has an eighteen-year history of a healed osteosarcoma of the right tibia that was treated with chemotherapy, resection, and allograft reconstruction. A literature review establishes this as the first reported case of a patient with synchronous and metachronous multicentric giant cell tumor who also has a history of osteosarcoma.

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Benign giant cell tumor of bone with pulmonary metastasis- report of two cases and review of literature

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20170676 ◽

2017 ◽

Vol 5 (3) ◽

pp. 1131

Author(s):

Geethu G. Nair ◽

Rajan G. ◽

Supriya N. K. ◽

Sathi P. P.

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Pulmonary Metastasis ◽

Past History ◽

Bone Lesion ◽

Giant Cells ◽

Tumor Location ◽

Cell Tumor ◽

Sarcomatous Transformation ◽

History Of

Tumors that are metastasizing generally considered as malignant. But there are exceptions. Giant cell tumor of bone is well known for its potential to metastasize without sarcomatous transformation. Potential of benign GCT to metastasize was first reported by Jaffe et al in 1940. Prevalence of pulmonary metastasis in benign GCT is between 1-9%. Factors favoring metastasis include recurrence of tumor, surgical manipulation of initial bone tumor, location of femur etc. Peripheral or basilar portion of pulmonary parenchyma is involved commonly. Eventhough death reported in 16-25% of cases, overall it has a favorable prognosis. Surgical resection is preferred treatment for pulmonary metastasis. In the present study 2 case studies were done. In 1st study 18 year old female, known case of GCT Lt tibia, with history of curetting and cementing presented with pain and swelling at same site and pulmonary metastasis 1 year later. Biopsy from initial as well as recurrent tumor confirmed benign GCT without any features of atypia, mitosis or necrosis. Aspirate from pulmonary lesion showed osteoclastic giant cells. No treatment given to metastatic deposits and is asymptomatic even though size of pulmonary lesions is increasing. And in second study a 22 year old female, with past history of GCT referred to our institution for evaluation of lung lesion detected in X-ray. Patient underwent metastatectomy here and histopathology was similar to that of bone lesion. There was no evidence of sarcomatous transformation both in initial and recurrent lesion. Patient is asymptomatic other wise and doing well.

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Dendriform Pulmonary Ossification in a Patient With a Past History of Giant Cell Tumor in Femur

Journal of Thoracic Imaging ◽

10.1097/rti.0b013e3181581931 ◽

2008 ◽

Vol 23 (1) ◽

pp. 47-49 ◽

Cited By ~ 5

Author(s):

Susumu Kobayashi ◽

Masaki Hara ◽

Motoki Yano ◽

Hisashi Tateyama ◽

Yuta Shibamoto

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Past History ◽

Cell Tumor ◽

History Of

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Giant cell tumor of the calvaria in a child

Journal of Neurosurgery ◽

10.3171/jns.1994.80.1.0148 ◽

1994 ◽

Vol 80 (1) ◽

pp. 148-151 ◽

Cited By ~ 15

Author(s):

Lee Reed ◽

Crystl D. Willison ◽

Sydney S. Schochet ◽

Joseph L. Voelker

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Cellular Tissue ◽

Cell Tumor ◽

Content Type ◽

History Of ◽

Rare Lesion ◽

Fine Print

✓ A giant cell tumor involving the vertex of the skull is described in a 3-year-old child with no history of head trauma. The mass was present approximately 4 months prior to resection. Microscopically, the lesion consisted of highly cellular tissue composed of oval to spindle-shaped stromal cells admixed with numerous multinucleated giant cells. Giant cell tumor of the skull is a rare lesion, usually involving the sphenoid or temporal bone in adults. The differential diagnosis is discussed with reference to the literature regarding giant cell lesions, especially of the cranium. The authors are unaware of previous reports of a similar lesion in this location in such a young child.

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Diffuse-Type Tenosynovial Giant Cell Tumor Arising in the Temporomandibular Joint Extending to the External Auditory Canal: A Case Report and Literature Review

Ear Nose & Throat Journal ◽

10.1177/01455613211002954 ◽

2021 ◽

pp. 014556132110029

Author(s):

Shiori Suzuki ◽

Hiroshige Tsuda ◽

Nobuyuki Bandoh ◽

Takashi Goto ◽

Akihiro Uemura ◽

...

Keyword(s):

Temporomandibular Joint ◽

Giant Cell Tumor ◽

Giant Cell ◽

External Auditory Canal ◽

Mandibular Condyle ◽

Cell Tumor ◽

Diffuse Type ◽

Tenosynovial Giant Cell Tumor ◽

History Of ◽

The Right

A 74-year-old Japanese woman with a 1-year history of right preauricular pain and a 2-month history of bleeding from the right ear was admitted to our department. Tumor was observed in the anterior wall in the right external auditory canal. Bony swelling of the right preauricular area was palpated. Computed tomography revealed an ill-defined, osteogenic tumor around the mandibular condyle with a destructive bony lesion involving the temporal bone. Magnetic resonance imaging revealed a 2.0 × 1.5 × 1.3-cm solid tumor around the mandibular condyle, exhibiting a low-intensity signal on T1-weighted imaging and an isointense central area surrounded by low-signal intensity on T2-weighted imaging. Histological examination of biopsy specimens revealed diffuse-type tenosynovial giant cell tumor (D-TGCT). After the feeding arteries for the tumor were embolized, the patient underwent surgery with combined temporal craniotomy and mandibular condylectomy. The soft and cystic tumor with calcification located in the extradural space was totally resected along with the mandibular condyle. No facial paralysis or recurrence was evident as of 6 months postoperatively. To date, only 23 cases of D-TGCT arising in the temporomandibular joint (TMJ) with ear involvement have been reported since 2011. We report successful resection of a rare case of D-TGCT arising in the TMJ.

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Giant cell tumor of tendon sheath in the wrist that damaged the extensor indicis proprius tendon: a case report and literature review

BMC Cancer ◽

10.1186/s12885-019-6293-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Qingfang Zhao ◽

Hui Lu

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Histopathological Examination ◽

Surgical Excision ◽

Tendon Sheath ◽

Cell Tumor ◽

Case Presentation ◽

Extensor Indicis Proprius ◽

History Of

Abstract Background Giant cell tumor of the tendon sheath (GCTTS) is a benign soft tissue (synovial membrane) tumor that rarely involves the hands or wrists. And Tendon impairment caused by GCTTS is extremely rare. Case presentation Here, we reported a case of a 60-year-old female with a 10-year history of gradually increasing mass in her left dorsal wrist. The EIP tendon was partially impaired by the mass.The patient was treated with surgical excision of the mass and reconstruction of the EIP tendon. The histopathological examination suggested the presence of GCTTS. After surgery, the patient had adequate functional recovery and no tumor recurrence after 2 years’ follow-up. Conclusion GCTTS in hands and wrists rarely damages the tendon. Early diagnosis and proactive interventions may likely contribute to good prognostic outcomes.

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