scholarly journals Association of Diabetic Retinopathy and Diabetic Kidney Disease With All-Cause and Cardiovascular Mortality in a Multiethnic Asian Population

2019 ◽  
Vol 2 (3) ◽  
pp. e191540 ◽  
Author(s):  
Charumathi Sabanayagam ◽  
Miao Li Chee ◽  
Riswana Banu ◽  
Ching-Yu Cheng ◽  
Su Chi Lim ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Cardiovascular Mortality ◽  
Diabetic Kidney Disease ◽  
Asian Population ◽  
Diabetic Kidney

scholarly journals Histopathological evaluation of kidney disease in patients with diabetes mellitus

2021 ◽  
Vol 8 (2) ◽  
pp. 112-119
Author(s):  
Juju Raj Shrestha ◽  
Kashyap Dahal ◽  
Anil Baral ◽  
Rajani Hada
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Patients ◽  
Rapid Rise ◽  
Class Iii ◽  
Diabetic Kidney ◽  
Duration Of Diabetes

Introduction: Non diabetic kidney disease (NDKD), a treatable condition, is common in diabetic patients with atypical clinical presentations. Present study aimed to find out histopathological diagnosis of kidney disease in type 2 Diabetes mellitus with such presentations. Method: This was a hospital based cross sectional study conducted in Nephrology department, Bir hospital, Nepal from Aug 2019 to January 2021. Total 29 diabetic patients with atypical presentations, rapid rise of proteinuria alone (n=5), with microscopic hematuria (n=6), with impaired renal function (n=8) and rapid rise of creatinine with (n=8) or without (n=2) microscopic hematuria were included. The baseline information was recorded and kidney biopsy was performed. Result: The mean age of patients was 52.6±10.4 y and 22(75.9%) were male. Diabetic retinopathy (DR) was absent in 24(82.8%) patients. Presence of NDKD alone was in 6(20.7%) and superimposed on diabetic kidney disease (DKD) in 10(34.5%) with total NDKD in 16(55.2%) and isolated DKD in 13(44.8%) patients. Non diabetic kidney disease were glomerulonephritis 12(75%) with membranous nephropathy 4(25%) and IgA nephropathy 4(25%) patients. The significant difference between NDKD and isolated DKD was only the duration of diabetes < 5 y in 8(61.5%) of isolated DKD and ≥5 y in 13(81.2%) patients with NDKD (p=0.018). Diabetic retinopathy was absent in 6(100%) patients with isolated NDKD, 8(80%) of class III and 5(62.5%) of class IV DKD. Conclusion: Glomerulonephritis is the commonest NDKD in type 2 DM with atypical presentation and advance DKD (Class III & IV) is present even in absence of diabetic retinopathy and short duration of diabetes.

scholarly journals Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease

2019 ◽  
Vol 7 (1) ◽  
pp. e000726 ◽  
Author(s):  
Masayuki Yamanouchi ◽  
Mikiro Mori ◽  
Junichi Hoshino ◽  
Keiichi Kinowaki ◽  
Takeshi Fujii ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
End Stage Kidney Disease ◽  
Diabetic Kidney ◽  
Clinical Model ◽  
Renal Lesions ◽  
End Stage

ObjectiveThe predictive value of diabetic retinopathy on end-stage kidney disease (ESKD) has not been fully addressed in patients with type 2 diabetes and diabetic kidney disease.Research design and methodsWe studied 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease who were screened for diabetic retinopathy during the 1 month of kidney biopsy. We examined the association between retinopathy progression and renal lesions. We used Cox regression analyses to explore the risk of ESKD adjusting for known risk demographic and clinical variables. We assessed the incremental prognostic value of ESKD by adding diabetic retinopathy to the clinical variables.ResultsThe diabetic retinopathy progression positively correlated with all scores of renal lesions, especially with the glomerular-based classification (r=0.41), scores of interstitial fibrosis (r=0.41) and diffuse lesion (r=0.48). During a median follow-up of 5.7 years, 114 patients developed ESKD. Adjusting for known risk factors of ESKD, the HR for ESKD (patients with no apparent retinopathy as a reference) were 1.96 (95% CI 0.62 to 6.17) for patients with mild non-proliferative diabetic retinopathy (NPDR), 3.10 (95% CI 1.45 to 6.65) for patients with moderate NPDR, 3.03 (95% CI 1.44 to 6.37) for patients with severe NPDR, and 3.43 (95% CI 1.68 to 7.03) for patients with proliferative diabetic retinopathy, respectively. Addition of the retinopathy grading to the clinical model alone improved the prognostic value (the global χ2 statistic increased from 155.2 to 164.5; p<0.001), which is an improvement equivalent to the addition of the renal lesion grading to the clinical model.ConclusionsRetinopathy progression appeared to be associated with renal lesions and the development of ESKD. Our findings suggest that diabetic retinopathy and kidney disease share the same magnitude of disease progression, and therefore diabetic retinopathy may be useful for prognosticating the clinical course for diabetic kidney disease.

scholarly journals Anemia and Diabetic Kidney Disease Had Joint Effect on Diabetic Retinopathy Among Patients With Type 2 Diabetes

2020 ◽  
Vol 61 (14) ◽  
pp. 25
Author(s):  
Jianyong Wang ◽  
Xing Xin ◽  
Wenliang Luo ◽  
Ruojie Wang ◽  
Xinyi Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Joint Effect ◽  
Diabetic Kidney

scholarly journals MON-156 Association of Adhesion Molecule with Diabetes, Diabetic Retinopathy, and Diabetic Kidney Disease

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Khalid Siddiqui ◽  
Shaik Nawaz ◽  
Teena George ◽  
Salini Joy ◽  
Khalid Al-Rubeaan
Keyword(s):  
Diabetic Retinopathy ◽  
Kidney Disease ◽  
Adhesion Molecule ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney

DNA Methylation Changes Associated with Type 2 Diabetes and Diabetic Kidney Disease in an East Asian Population

2021 ◽  
Author(s):  
Hakyung Kim ◽  
Jae Hyun Bae ◽  
Kyong Soo Park ◽  
Joohon Sung ◽  
Soo Heon Kwak
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Fasting Glucose ◽  
East Asian ◽  
Asian Population ◽  
Diabetic Kidney ◽  
Metabolic Phenotypes

Abstract Background There is a growing body of evidence that epigenetic changes including DNA methylation influence the risk of type 2 diabetes (T2D) and its microvascular complications. We conducted a methylome-wide association study (MWAS) to identify differentially methylated sites (DMSs) of T2D and diabetic kidney disease (DKD) in a Korean population. Methods We performed an MWAS in 232 participants with T2D and 197 non-diabetic controls with Illumina EPIC bead chip using peripheral blood leukocytes. T2D group was subdivided into 87 DKD cases and 80 non-DKD controls. Additional 819 individuals from two population-based cohorts were used to investigate the association of identified DMSs with quantitative metabolic phenotypes. Mendelian randomization (MR) approach was applied to evaluate the causal effect of metabolic phenotypes on identified DMSs. Results We identified eight DMSs (each at BMP8A, NBPF20, STX18, ZNF365, CPT1A, and TRIM37, and two at TXNIP) which were significantly associated with the risk of T2D (P &lt; 9.0×10 -8), including three that were previously known (DMSs in TXNIP and CPT1A). We also identified three DMSs (in COMMD1, TMOD1, and FHOD1) associated with DKD. With our limited sample size, we were not able to observe a significant overlap between DMSs of T2D and DKD. DMSs in TXNIP and CTP1A were associated with fasting glucose and HbA1c. In MR analysis, fasting glucose was causally associated with DMS in CPT1A. Conclusions In an East Asian population, we identified eight DMSs, including five novel CpG loci, associated with T2D and three DMSs associated with DKD at methylome-wide statistical significance.

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