Regional Lymph Node Involvement Among Patients With De Novo Metastatic Breast Cancer

Introduction: Breast cancer is the leading cause of cancer-related deaths in women aged 20-59 years. Younger women usually have more aggressive tumors and more advanced disease with larger size and axillary lymph node involvement. There have been few studies assessing the characteristics of breast cancer in very young women. Objective: Evaluate the epidemiological and clinical profile of non-metastatic very young patients with breast cancer. Method: We performed a retrospective analysis to evaluate the epidemiological and clinical profile of non-metastatic breast cancer in patients ≤ 30 years of age treated between 1993 and 2011 at the Brazilian National Cancer Institute José Alencar Gomes da Silva. We evaluated relapse-free survival (RFS) and overall survival (OS). Results: Of the 196 patients evaluated, 181 (90%) had ductal carcinoma, 79 (40%) had high-grade tumors, and 102 (52%) had hormone receptor-positive tumors. 117 patients(60%) had stage III disease at diagnosis. The median age was 29 years (range, 17-30 years). Of 185 patients who underwent surgery, 156 (84.3%) underwent total mastectomy and 171 (92%) underwent axillary lymph node dissection. 119 patients received neoadjuvant chemotherapy, and 14 patients (9.3%) underwent neoadjuvant radiotherapy. After a median follow-up of 81.5 months, 109 patients (55%) had relapsed and 81 (41%) had died. The median RFS and OS were 49.5 months and 134 months, respectively. Lymph node involvement and neoadjuvant chemotherapy were associated with shorter RFS and OS. Conclusion: Breast cancer is uncommon in young patients, especially in those ≤ 30 years of age. We found a predominance of locally advanced disease and worse prognostic pathological characteristics. Despite the aggressive treatment, our patients had worse outcomes than those reported by other authors.

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Breast cancer with extensive regional lymph node involvement: Toward optimizing local management.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.1053 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. 1053-1053

Author(s):

Lior Zvi Braunstein ◽

Sigolene Galland ◽

Saveli Goldberg ◽

Betro T. Sadek ◽

Mina Shenouda ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Regional Lymph Node ◽

Lymph Node Involvement ◽

Local Management ◽

Regional Lymph Node Involvement ◽

Node Involvement

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The Microanatomic Location of Metastatic Breast Cancer in Sentinel Lymph Nodes Predicts Nonsentinel Lymph Node Involvement

Annals of Surgical Oncology ◽

10.1245/s10434-007-9803-z ◽

2008 ◽

Vol 15 (5) ◽

pp. 1309-1315 ◽

Cited By ~ 16

Author(s):

Carolien H. M. van Deurzen ◽

Cees A. Seldenrijk ◽

Ron Koelemij ◽

Richard van Hillegersberg ◽

Monique G. G. Hobbelink ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Lymph Node ◽

Lymph Nodes ◽

Metastatic Breast ◽

Lymph Node Involvement ◽

Sentinel Lymph Nodes ◽

Node Involvement ◽

Nonsentinel Lymph Node

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A Russian nomogram for assessing the risk of metastatic regional lymph node involvement in patients with breast cancer

Akusherstvo i ginekologiia ◽

10.18565/aig.2020.2.76-81 ◽

2020 ◽

Vol 2_2020 ◽

pp. 76-81

Author(s):

Rodionov V.V. Rodionov ◽

Kometova V.V. Kometova ◽

Idrisova S.R. Idrisova ◽

Savinov Yu.G. Savinov Yu ◽

Balashov I.S. Balashov ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Regional Lymph Node ◽

Lymph Node Involvement ◽

Regional Lymph Node Involvement ◽

Node Involvement

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Role of clinical and morphological data in prediction of regional lymph node involvement in early-stage breast cancer

Tumors of female reproductive system ◽

10.17650/1994-4098-2019-15-1-29-34 ◽

2019 ◽

Vol 15 (1) ◽

pp. 29-34

Author(s):

Yu. S. Shatova ◽

L. N. Vashchenko ◽

E. S. Bosenko ◽

S. M. Bakulina ◽

V. N. Kasyanenko ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Primary Tumor ◽

Regional Lymph Node ◽

Lymph Node Involvement ◽

Morphological Data ◽

Significant Prognostic Factor ◽

Axillary Lymph ◽

Regional Lymph Node Involvement ◽

Node Involvement

Objective:to evaluate the frequency of axillary lymph node metastasis (detected at routine pathomorphological examination) in order to determine the group of patients who do not require lymph node surgery.Materials and methods.We analyzed medical records of 485 patients with breast cancer and no signs (either clinical or instrumental) of regional lymph node involvement who underwent surgery at the first stage of their treatment.Results and conclusion.In patients with cN0 cancer, only the size of primary tumor ≤1 cm was found to be a significant factor indicating that regional lymph nodes are not involved (in addition to palpation, ultrasound, mammography, and spiral x-ray computed tomography of the chest). In patients with сТ1c cancer, the majority of standard immunohistochemical markers cannot yet be used as predictors of regional lymph node involvement. However, tumor differentiation grade G1 is rather an exclusion, which in combination with the size of the primary tumor сТ1c can also be considered as a significant prognostic factor.

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Molecular genetic prognostic factors for metastatic regional lymph node involvement in breast cancer patients

Akusherstvo i ginekologiia ◽

10.18565/aig.2020.3.141-147 ◽

2020 ◽

Vol 3_2020 ◽

pp. 141-147

Author(s):

Dergunova Yu.A. Dergunova ◽

Bozhenko V.K. Bozhenko ◽

Podionov V.V. Podionov ◽

Kometova V.V. Kometova ◽

Makarova M.V. Makarova ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Cancer Patients ◽

Regional Lymph Node ◽

Molecular Genetic ◽

Lymph Node Involvement ◽

Breast Cancer Patients ◽

Regional Lymph Node Involvement ◽

Node Involvement

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Clinical profile of carcinoma breast cases at a tertiary care hospital

International Surgery Journal ◽

10.18203/2349-2902.isj20170459 ◽

2017 ◽

Vol 4 (3) ◽

pp. 913 ◽

Cited By ~ 1

Author(s):

Arifa Almas

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Regional Lymph Node ◽

Clinical Stage ◽

Distant Metastases ◽

Lymph Node Involvement ◽

Breast Cancer Patients ◽

Medical College ◽

Regional Lymph Node Involvement ◽

Node Involvement

Background: Breast carcinoma is a serious health problem and is among the major health issues in India. Also, it has a relatively early age presentation in this part of the world. Present study describes the features like age at presentation, clinical stage at presentation and incidence of regional lymph node involvement and distant metastases among the breast cancer patients at Government Medical College, Jabalpur in Madhya Pradesh, India.Methods: This hospital-based descriptive study was conducted at the Department of Surgery, Government Medical College, Jabalpur in Madhya Pradesh state of India. Fifty patients with a confirmed diagnosis of breast cancer were included in the study. The details like age at presentation, clinical stage at presentation and incidence of regional lymph node involvement and distant metastases among the breast cancer patients were described and tabulated.Results: Youngest patient of the series was aged 30 years whereas the oldest was aged 65 years. Maximum patients belonged to 41 to 50 years age group. Stage wise distribution of cases reflected that Stage III was the most common stage at presentation. Majority of the cases had lymph node involvement (90%). Liver metastasis was seen in 8 cases (16%), of which, 2 cases had ascites. There were 6 cases of lung metastasis, of which 2 cases had pleural effusion and remaining 4 cases showed solitary metastasis. 6 cases of osseous metastasis were observed, out of which, 2 cases had skull metastasis and 4 cases had spine involvement.Conclusions: It was found that the age group in majority of the patients was younger as compared to Western world and this finding is in line with data from India and other Asian regions. Also, there was a presentation at a later stage of disease in our study population.

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Clinical, morphological and molecular predictors of metastatic regional lymph node involvement in breast cancer patients

Malignant tumours ◽

10.18027/2224-5057-2019-9-3-12-19 ◽

2019 ◽

Vol 9 (3) ◽

pp. 12-19

Author(s):

Yu. A. Dergunova ◽

V. V. Rodionov ◽

V. V. Kometova

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Cancer Patients ◽

Regional Lymph Node ◽

Lymph Node Involvement ◽

Breast Cancer Patients ◽

Regional Lymph Node Involvement ◽

Node Involvement

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Histopathological Analysis of Mucinous Breast Cancer Subtypes and Comparison with Invasive Carcinoma of no Special Type.

10.21203/rs.3.rs-103605/v1 ◽

2020 ◽

Author(s):

Michał Piotr Budzik ◽

Marta Magdalena Fudalej ◽

Anna Maria Badowska-Kozakiewicz

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Regional Lymph Node ◽

Histological Grade ◽

Lymph Node Involvement ◽

Biological Behavior ◽

Histopathological Analysis ◽

Breast Cancers ◽

Regional Lymph Node Involvement ◽

Node Involvement

Abstract BackgroundMucinous breast cancer (MBC) is a rare histological type of breast cancer characterized primarily by the production and extracellular presence of mucin and it is usually associated with a better prognosis than other invasive breast neoplasms. Because of the low prevalence, MBC biology is not well understood. MethodsThe aim of the present study was to introduce the last 2-year experience regarding MBC pathological diagnostics in our clinical center and comparison of the obtained data with invasive breast carcinoma of no special type (NST) comprising the most common invasive breast cancer. ResultsWe identified 24 MBC cases representing 3.09% of all 766 invasive breast cancers, including 15 cases of pure type and 9 mixed MBCs. The median MBC patients’ age at presentation was 65.5 years. In comparison to NST, MBC presented a higher T stage with a statistically larger tumor median size, although lower regional lymph node involvement, tumor histological grade and TNM stage. ConclusionMBC is a rare type of breast cancer accounting for about 4% of all diagnosed breast cancers. Our findings are consistent with those published in recent years and show significant differences between MBC and NST cancer patients and also highlight differences between pure and mixed MBC emphasizing the essence of their differentiation. MBC is associated with a better long-term prognosis than NST and is characterized by the less aggressive biological behavior expressed through favorable clinicopathologic features in terms of tumor grade, regional lymph node involvement and hormone receptor status.

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