Seroprevalence of Measles and Mumps Antibodies Among Individuals With Cancer

SUMMARYWe examined the prevalence of mumps antibodies in the Israeli population in relation to mumps vaccination policy and past and subsequent incidence of disease. The levels of specific IgG antibodies against mumps were tested in 3330 residual sera collected during 1997–1998 from an age-stratified population sample. Against the background of a consistent MMR vaccination coverage of >90%, the age- and sex-adjusted seropositivity to mumps was 77·0%. No significant differences between genders were found. Seropositivity in the 10–13 years age group, born just before the introduction of the MMR vaccine, was the lowest (59%). These birth cohorts were the target of an outbreak of mumps in 2005 that occurred among high-school students and military recruits. A trend of waning immunity was observed between the first and second vaccine doses. The seroepidemiological data demonstrate that immunity levels below the herd immunity threshold, along with social mixing and crowded conditions facilitated the occurrence of mumps outbreaks. Periodical serosurveys are an essential component in the evaluation of the vaccination policy against mumps.

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Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

Human Vaccines & Immunotherapeutics ◽

10.1080/21645515.2017.1412021 ◽

2018 ◽

Vol 14 (4) ◽

pp. 887-893 ◽

Cited By ~ 5

Author(s):

Jan Smetana ◽

Roman Chlibek ◽

Irena Hanovcova ◽

Renata Sosovickova ◽

Libuse Smetanova ◽

...

Keyword(s):

Czech Republic ◽

Vaccination Strategy ◽

Serological Survey ◽

The Czech Republic ◽

Mumps Antibodies

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Maternal mumps antibodies in a cohort of children up to the age of 1 year

European Journal of Pediatrics ◽

10.1007/s00431-012-1691-y ◽

2012 ◽

Vol 171 (8) ◽

pp. 1167-1173 ◽

Cited By ~ 12

Author(s):

E. Leuridan ◽

N. Goeyvaerts ◽

N. Hens ◽

V. Hutse ◽

P. Van Damme

Keyword(s):

Mumps Antibodies

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Sero-prevalence of mumps antibodies in subpopulations subsequently affected by a large scale mumps epidemic in Israel

Vaccine ◽

10.1016/j.vaccine.2011.03.047 ◽

2011 ◽

Vol 29 (22) ◽

pp. 3878-3882 ◽

Cited By ~ 9

Author(s):

Khitam Muhsen ◽

Tamy Shohat ◽

Yair Aboudy ◽

Ella Mendelson ◽

Nurit Algor ◽

...

Keyword(s):

Large Scale ◽

Mumps Antibodies

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Proportions of Ig Classes and Subclasses in Mumps Antibodies

Scandinavian Journal of Immunology ◽

10.1111/j.1365-3083.1985.tb01890.x ◽

1985 ◽

Vol 22 (3) ◽

pp. 345-350 ◽

Cited By ~ 10

Author(s):

A. SARNESTO ◽

I. JULKUNEN ◽

O. MAKELA

Keyword(s):

Mumps Antibodies

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Persistence of rubella and mumps antibodies, following changes in the recommended age for the second dose of MMR vaccine in Portugal

Epidemiology and Infection ◽

10.1017/s0950268816001655 ◽

2016 ◽

Vol 144 (15) ◽

pp. 3139-3147 ◽

Cited By ~ 1

Author(s):

G. GONÇALVES ◽

J. FRADE ◽

M. S. J. NASCIMENTO ◽

J. R. MESQUITA ◽

C. NUNES

Keyword(s):

Geometric Mean ◽

Igg Antibodies ◽

Birth Cohorts ◽

Mmr Vaccine ◽

High Coverage ◽

Previous Evidence ◽

Specific Antibodies ◽

Mumps Antibodies ◽

Very High

SUMMARYIn Portugal, the recommended age for the second dose of MMR (MMR2) was changed from 10–13 years to 5–6 years for those born in 1994 and afterwards. This study aimed to assess if MMR schedule and time elapsed from the last dose are associated with the concentration of rubella and mumps IgG antibodies. Three Portuguese birth cohorts (convenience samples) were selected for this study (66, 59 and 41 participants born respectively in 1990–1993, 1994–1995 and 2001–2003). Geometric mean concentrations (GMC) for mumps IgG were respectively 36, 30 and 38 RU/ml (P = 0·236) and for rubella IgG were 18, 20 and 17 IU/ml (P = 0·641). For both specific antibodies, no differences were observed with time since MMR2. Receiving MMR2 at 5–6 or 10–13 years was not associated with concentration of both antibodies. The GMC of rubella IgG was lower in males (P = 0·029). Taking into account previous evidence and the logistics needed to change vaccination schedules, it seems reasonable that sustaining very high coverage with two doses of MMR is currently the most pragmatic way to control mumps and rubella rather than any changes to the schedule.

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New tests for characterization of mumps virus antibodies: hemolysis inhibition, single radial immunodiffusion with immobilized virions, and mixed hemadsorption

Journal of Clinical Microbiology ◽

10.1128/jcm.5.3.346-352.1977 ◽

1977 ◽

Vol 5 (3) ◽

pp. 346-352

Author(s):

E Norrby ◽

M Grandien ◽

C Orvell

Keyword(s):

Acute Infection ◽

High Sensitivity ◽

Mumps Virus ◽

Radial Immunodiffusion ◽

Specific Identification ◽

Single Radial Immunodiffusion ◽

Antibody Titers ◽

Mumps Antibodies ◽

Mixed Hemadsorption Test

Hemolysis inhibition (HLI), single radial immunodiffusion (SRID) with immobilized virions, and mixed hemadsorption tests were used for measuring antibodies against mumps virus. Rabbit hyperimmune sera against mumps and early and late human convalescent sera were analyzed. All three tests identified antibodies against both hemagglutinin and the second major envelope component, hemolysin (fusion factor). The sensitivity of the HLI test corresponded to that of the hemagglutination inhibition (HI) test, but in some sera HLI antibodies occurred in greater quantity than HI antibodies. The SRID test readily identified rises in antibody titers in connection with acute infection. Due to its simplicity and lack of sensitivity to nonspecific inhibitors, it is recommended for use in this context. The mixed hemadsorption test showed a high sensitivity for specific identification of mumps antibodies. It therefore may be suitable for use in screening for immunity to mumps.

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