Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers

This study used an explanatory sequential mixed-method design to explore the association between familial interdependence and familial mentoring relationship presence within black families. This study also examined how socioeconomic disadvantage may moderate the association between familial interdependence and familial mentoring presence. A sample of 216 black youth (59% girls; 41% boys) were surveyed, and a subsample of 25 participants were interviewed along with one of their parents, and one nonparental familial adult with whom the youth reported feeling emotionally close to learn more about the enactment of familial interdependence and the formation of familial mentoring relationships across social class. Logistic regression analyses revealed that greater valuing of familial interdependence was associated with a greater likelihood of having a familial mentoring relationship, but this association was present only among nonsocioeconomically disadvantaged youth. Data collected from participant interviews were analyzed to better understand this pattern of findings. These analyses provided some preliminary insights into why familial interdependence may predict familial mentor formation only among nonsocioeconomically disadvantaged youth. Implications of study findings for the promotion of familial mentoring relationships within black families are discussed.

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The Impact of Socioeconomic Disadvantage on Pediatric Tracheostomy Outcomes

The Laryngoscope ◽

10.1002/lary.29576 ◽

2021 ◽

Author(s):

Kershena Liao ◽

Stephen R. Chorney ◽

Ashley B. Brown ◽

Rebecca L. Brooks ◽

Ashley Sewell ◽

...

Keyword(s):

Socioeconomic Disadvantage ◽

The Impact

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Changes in neighborhood-level socioeconomic disadvantage and older Americans’ cognitive functioning

Health & Place ◽

10.1016/j.healthplace.2021.102510 ◽

2021 ◽

Vol 68 ◽

pp. 102510

Author(s):

Jason Settels ◽

Anja K. Leist

Keyword(s):

Cognitive Functioning ◽

Socioeconomic Disadvantage ◽

Older Americans ◽

Neighborhood Level

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Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

Scientific Reports ◽

10.1038/s41598-021-82714-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Cristian Carmeli ◽

Zoltán Kutalik ◽

Pashupati P. Mishra ◽

Eleonora Porcu ◽

Cyrille Delpierre ◽

...

Keyword(s):

Dna Methylation ◽

Gene Regulation ◽

Cohort Studies ◽

Early Life ◽

Life Experiences ◽

Socioeconomic Disadvantage ◽

Mediating Role ◽

The Impact ◽

The Relationship

AbstractIndividuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.

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