Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases

: Recently, an increasing number of biological and clinical reports have demonstrated that imbalance of microbial community has the ability to play important roles among several complex diseases concerning human health. Having a good knowledge of discovering potential of microbe-disease relationships, which provides the ability to having a better understanding of some issues, including disease pathology, further boosts disease diagnostics and prognostics, has been taken into account. Nevertheless, a few computational approaches can meet the need of huge scale of microbe-disease association discovery. In this work, we proposed the EHAI model, which is Enhanced Human microbe- disease Association Identification. EHAI employed the microbe-disease associations, and then Gaussian interaction profile kernel similarity has been utilized to enhance the basic microbe-disease association. Actually, some known microbe-disease associations and a large amount of associations are still unavailable among the datasets. The ‘super-microbe’ and ‘super-disease’ were employed to enhance the model. Computational results demonstrated that such super-classes have the ability to be helpful to the performance of EHAI. Therefore, it is anticipated that EHAI can be treated as an important biological tool in this field.

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Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems

Biosensors ◽

10.3390/bios10090110 ◽

2020 ◽

Vol 10 (9) ◽

pp. 110 ◽

Cited By ~ 2

Author(s):

Erika Ferrari ◽

Cecilia Palma ◽

Simone Vesentini ◽

Paola Occhetta ◽

Marco Rasponi

Keyword(s):

Imaging Techniques ◽

Biological Models ◽

Electromechanical Properties ◽

Human Organs ◽

Tissue Constructs ◽

Microphysiological Systems ◽

Metabolic Activities ◽

On Chip ◽

Chip Analysis

Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular environments, they represent promising tools for tissue engineering and drug screening applications. The achievement of proper functionalities within OoC is crucial; to this purpose, several parameters (e.g., chemical, physical) need to be assessed. Currently, most approaches rely on off-chip analysis and imaging techniques. However, the urgent demand for continuous, noninvasive, and real-time monitoring of tissue constructs requires the direct integration of biosensors. In this review, we focus on recent strategies to miniaturize and embed biosensing systems into organs-on-chip platforms. Biosensors for monitoring biological models with metabolic activities, models with tissue barrier functions, as well as models with electromechanical properties will be described and critically evaluated. In addition, multisensor integration within multiorgan platforms will be further reviewed and discussed.

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PS1-23: Capitalizing on the HMO Cancer Research Network (CRN): The Optimal Setting to Conduct Studies of Rare Complex Diseases

Clinical Medicine & Research ◽

10.3121/cmr.2013.1176.ps1-23 ◽

2013 ◽

Vol 11 (3) ◽

pp. 128-128

Author(s):

C. C. Johnson ◽

C. Chao ◽

L. Engel ◽

H. Feigelson ◽

J. Fortuny ◽

...

Keyword(s):

Cancer Research ◽

Complex Diseases ◽

Research Network ◽

Cancer Research Network ◽

Optimal Setting

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Harnessing the power of microphysiological systems for COVID-19 research

Drug Discovery Today ◽

10.1016/j.drudis.2021.06.020 ◽

2021 ◽

Author(s):

Nicole Kleinstreuer ◽

Anthony Holmes

Keyword(s):

Microphysiological Systems

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Microphysiological systems: What it takes for community adoption

Experimental Biology and Medicine ◽

10.1177/15353702211008872 ◽

2021 ◽

pp. 153537022110088

Author(s):

Passley Hargrove-Grimes ◽

Lucie A Low ◽

Danilo A Tagle

Keyword(s):

Rare Diseases ◽

Development Process ◽

Emerging Technology ◽

National Institutes Of Health ◽

Drug Development Process ◽

Microphysiological Systems ◽

Pediatric Populations ◽

Neural Disorders ◽

Future Path

Microphysiological systems (MPS) are promising in vitro tools which could substantially improve the drug development process, particularly for underserved patient populations such as those with rare diseases, neural disorders, and diseases impacting pediatric populations. Currently, one of the major goals of the National Institutes of Health MPS program, led by the National Center for Advancing Translational Sciences (NCATS), is to demonstrate the utility of this emerging technology and help support the path to community adoption. However, community adoption of MPS technology has been hindered by a variety of factors including biological and technological challenges in device creation, issues with validation and standardization of MPS technology, and potential complications related to commercialization. In this brief Minireview, we offer an NCATS perspective on what current barriers exist to MPS adoption and provide an outlook on the future path to adoption of these in vitro tools.

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