The Common Coordinate Framework (CCF) Organ VR Gallery

The CCF Organ VR Gallery lets the user explore 21 human organs, journeying from the Whole Body, to the Organ, to the Cell stage and back, presented in real-world size and 3D. The user discovers hidden regions by exploding and collapsing organs into their individual anatomical structures. We show cell type populations for a kidney using a data-driven dot density visualization. The organ models were developed to map trillions of cells for the Human BioMolecular Atlas Program (HuBMAP).

Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress

Clinical islet allotransplantation has been successfully regulated as tissue/organ for transplantation in number of countries and is recognized as a safe and efficacious therapy for selected patients with type 1 diabetes mellitus. However, in the United States, the FDA considers pancreatic islets as a biologic drug, and islet transplantation has not yet shifted from the experimental to the clinical arena for last 20 years. In order to transplant islets, the FDA requires a valid Biological License Application (BLA) in place. The BLA process is costly and lengthy. However, despite the application of drug manufacturing technology and regulations, the final islet product sterility and potency cannot be confirmed, even when islets meet all the predetermined release criteria. Therefore, further regulation of islets as drugs is obsolete and will continue to hinder clinical application of islet transplantation in the US. The Organ Procurement and Transplantation Network together with the United Network for Organ Sharing have developed separately from the FDA and BLA regulatory framework for human organs under the Human Resources & Services Administration to assure safety and efficacy of transplantation. Based on similar biologic characteristics of islets and human organs, we propose inclusion of islets into the existing regulatory framework for organs for transplantation, along with continued FDA oversight for islet processing, as it is for other cell/tissue products exempt from BLA. This approach would reassure islet quality, efficacy and access for Americans with diabetes to this effective procedure.

Effects of Microenvironmental Factors on Assessing Nanoparticle Toxicity

Nanoparticles, such as dust or fine particles produced from diverse sources, are regarded as hazardous materials to human organs, and the interest in understanding their biological mechanisms and evaluating the...

The phenomenon of human organ trafficking in light of the United Nations sustainable development agenda with special emphasis on cultural offences in Republic of Kosovo

The article concerns the issues related to the illegal trade in human tools in the light of the theoretical structure of sustainable development created by the United Nations (UN). The text consists of several parts. The work aims to show the following research areas: – axiological and legal assumptions of sustainable development in the context of a triple win: social, economic and environmental, – the criminological profile and picture of organized crime in the Republic of Kosovo – trafficking in human organs in the territory of the Republic of Kosovo, – information on traditional customary law (Kanun) in Albanian culture – analysis of the phenomenon of harvesting human organs in Kosovo. The last part of the article presents the economic, social and criminological problems of Kosovo in the context of the Sustainable Development Agenda.The analysis contained in the text proves that the youngest European country (2008) struggles with many problems of a legal, economic and social nature. These problems are not only a consequence of the recent post-Slavic armed conflicts but also result from the specific Albanian legal culture (Kanun rules), which still affects the functioning of this society (especially in the provinces). Therefore, these customs still determine the level of crime in this country, both common and related to the activities of organized crime groups (with particular emphasis on trafficking in human organs). Therefore, it is recommended to successively implement the legal solutions contained in the Agenda for Sustainable Development, to stabilize not only this country but the entire region.

The Lens of “Thingness”

Environmental medicine and related fields have developed from a structural perspective that assigns a static, anatomical “thingness” to our physiology and our environment. This viewpoint arises from a reductionist school of thought and foundational biomedical discoveries such as the discovery that human organs are made up of cells organized as tissues or that our DNA is the source “code” for the building blocks of life. As a consequence of these discoveries and their perceived importance, medical sciences have organized the study of the human body into the study of component parts. Attempts to incorporate time into existing structural perspectives have often taken the form of multiple structural analyses laced together as a circuit operating in a series of connections. Such approaches ignore that humans and their environment are temporally dynamic processes. Environmental Biodynamics argues for a functional perspective that rejects the reductionist view of human physiology and the human environment. In stark contrast to the prevalent structural paradigms, this approach places temporal dynamics at its core.

Conducting Studies of the Am-241 Radionuclide Incorporated into the Human Body Using a Wound Detector

Purpose: to develop a method for experimental study of the distribution of radionuclide 241Am in human organs and tissues during wound admission to clarify the process of formation of doses of alpha radiation. Material and methods: in clinical practice of Burnazyan FMBC of the FMBA of Russia To improve the method of determination, an experiment was performed to determine the depth of radionuclide on pigskin with the location of 241Am point sources behind different thicknesses. Results: the used methods of measurement, tested on pigskin, allowed to obtain the dependence of the localization depth of radionuclide 241Am on the measured on the surface of the tissue ratios of photons with different energies. Conclusion: Set the ratio of photons with different energies on the thickness of the barrier (depth), and proven methodology allow you to go directly to the planning of experimental studies on the barrier effect created in the bone material, and including a radionuclide, the formation of doses of alpha radiation on the bone marrow.

Criminal liability for illegal transplantation: past, present, future

Transplantation of human anatomical materials is an important method of treatment aimed at restoring human health, so improving the criminal law regulation of combating illegal transplantation is certainly important. This article provides a comprehensive scientific and practical analysis of the formation, development and reform of legislation that provides transplantation of anatomical materials to humans. To do this, the author systematically studied the regulatory legislation in the field of transplantation and the changes that have taken place in it, identified all the changes made to Art. 143 of the Criminal Code of Ukraine during its validity, the impact of these changes on the practice of application of Art. 143 of the Criminal Code of Ukraine. The study of the legal support of transplantation was conducted through three main stages of transformation of legislation during the independence of Ukraine. This allowed us to draw the following conclusions: 1) the subject of the crimes under Art. 143 today is human anatomical materials. This means that, in addition to human organs or tissues, it covers anatomical formations, human cells and human fetal materials; 2) the systematic change of regulatory legislation in the field of transplantation complicates the establishment of the current procedure and conditions of transplantation of human anatomical materials, and, as a consequence, complicates the detection of signs of illegal transplantation; 3) the current corpus delicti provided in Part 1 of Art. 143 of the Criminal Code, is material, which requires the establishment, in addition to the act, socially dangerous consequences (significant harm to the victim) and the causal link between the act and the consequence; 4) the subjective side of the crime provided by part 1 of Art. 143 of the Criminal Code, from the moment of adoption of the Criminal Code of Ukraine until December 28, 2019, both intentional and negligent violation of the statutory procedure for transplantation of human anatomical materials was criminally punished, and from December 29, 2019, the act can only be intentional and the attitude to consequences only negligent; 5) since the adoption of the Criminal Code of Ukraine and until now, the legislator has twice increased the penalties for crimes under Art. 143 of the Criminal Code. In the final case, the penalty was increased for all sanctions under Art. 143 of the Criminal Code without exception.

Representation of Religious Values in Gurindam Twelve and Their Relevances with Modern Era

This study uses Roland Barthes' semiotic analysis to examine the meaning of the advice contained in Gurindam Twelve chapter 3 by Raja Ali Haji. This study uses a qualitative research method with an interpretive approach. This research is classified as interpretive research because it relies on interpreting texts associated with ideological, moral, cultural, and spiritual values. The researcher aims to analyze the meaning of the advice in Gurindam Twelve chapter 3 in its semiotic aspect and relate the relevance of the importance of the advice in Gurindam conveyed to today's society. From the study results, it can be concluded that in Article 3 Gurindam Twelve, the meaning of the denotation is the cause and effect of protecting human organs to avoid harmful and useless things. Guarding human organs, but in its meaning, it is not merely teaching organs. From the interpretation of these organs, it means a habit, nature, work which, when we do not take care of it, will cause harm to ourselves and even to others. The myth in chapter 3, Gurindam Twelve 3, contains self-control advice for the reader. In addition, the Twelve Gurindam Article 3 contains Islamic religious values in terms of morals and etiquette. This is evidenced by the verses of the Qur'an and hadiths that are relevant to the meaning contained in this Gurindam Twelve Aat 3 advice. In addition, the advice in article 3 of the Gurindam Twelve is relevant to be a life guide for today's society.