New derivatives of 4-alkyl-3,5-diaryl-4H-1,2,4-triazole were synthesized utilizing the Suzuki cross-coupling reaction. The presented methodology comprises of the preparation of bromine-containing 4-alkyl-4H-1,2,4-triazoles and their coupling with different commercially available boronic acids in the presence of ionic liquids or in conventional solvents. The obtained compounds were tested for their luminescence properties.
Carbonyl sulfide (OCS), the
component of volcanic emission, has
been found to induce the condensation of amino acids under simulated primordial
earth conditions. However, the applications
of OCS in peptide chemical synthesis is still limited by their heterogeneities
and low efficiencies. We herein report an OCS-mediated approach for solid-phase peptide synthesis using amino
acid ionic liquids as recyclable reactants. The coupling reactions required no base
and solvent and was completed in minutes at room temperature. The applicability
and sustainability of this approach were demonstrated by the facile syntheses
of peptides with remarkably high yields.
Synthesis of 4-Alkyl-4H-1,2,4-triazole Derivatives by Suzuki Cross-coupling Reactions and Their Luminescence Properties
