Peptide Design by Nature-Inspired Algorithms

2013 ◽  
pp. 437-465 ◽  
Author(s):  
Jan A. Hiss ◽  
Gisbert Schneider
2019 ◽  
Vol 20 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Zhongyan Li ◽  
Qingqing Miao ◽  
Fugang Yan ◽  
Yang Meng ◽  
Peng Zhou

Background:Protein–peptide recognition plays an essential role in the orchestration and regulation of cell signaling networks, which is estimated to be responsible for up to 40% of biological interaction events in the human interactome and has recently been recognized as a new and attractive druggable target for drug development and disease intervention.Methods:We present a systematic review on the application of machine learning techniques in the quantitative modeling and prediction of protein–peptide binding affinity, particularly focusing on its implications for therapeutic peptide design. We also briefly introduce the physical quantities used to characterize protein–peptide affinity and attempt to extend the content of generalized machine learning methods.Results:Existing issues and future perspective on the statistical modeling and regression prediction of protein– peptide binding affinity are discussed.Conclusion:There is still a long way to go before establishment of general, reliable and efficient machine leaningbased protein–peptide affinity predictors.


Author(s):  
Niam Abdulmunim Al-Thanoon ◽  
Omar Saber Qasim ◽  
Zakariya Yahya Algamal

2006 ◽  
Vol 11 (1) ◽  
pp. 7-21 ◽  
Author(s):  
Ignasi Belda ◽  
Sergio Madurga ◽  
Teresa Tarragó ◽  
Xavier Llorà ◽  
Ernest Giralt

Stats ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 71-85
Author(s):  
Hossein Hassani ◽  
Mohammad Reza Yeganegi ◽  
Xu Huang

Fusing nature with computational science has been proved paramount importance and researchers have also shown growing enthusiasm on inventing and developing nature inspired algorithms for solving complex problems across subjects. Inevitably, these advancements have rapidly promoted the development of data science, where nature inspired algorithms are changing the traditional way of data processing. This paper proposes the hybrid approach, namely SSA-GA, which incorporates the optimization merits of genetic algorithm (GA) for the advancements of Singular Spectrum Analysis (SSA). This approach further boosts the performance of SSA forecasting via better and more efficient grouping. Given the performances of SSA-GA on 100 real time series data across various subjects, this newly proposed SSA-GA approach is proved to be computationally efficient and robust with improved forecasting performance.


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