Post hydrothermal liquefaction wastewater (PHWW) was generated during biocrude oil production. It contains lots of carbon, nitrogen and phosphorous elements, which can cause environmental pollution and resource waste. Using photosynthetic bacteria (PSB) to treat this kind of wastewater can realize pollutants elimination and resource recovery. In this work, the feasibility of using PSB to treat PHWW was firstly investigated, and the treatment conditions were optimized. Results showed that the PSB can effectively degrade PHWW. The optimal initial COD concentration, inoculum size and light intensity for PSB to treat PHWW were 6000-10000 mg/L, 50 mg/L and 1000-3500 lux, respectively. With the initial COD concentration of 9000 mg/L, inoculum size of 50 mg/L and light intensity of 1000 lux, the COD, NH3-N, TP removal and biomass production reached to 71%, 90%, 47.2% and 773 mg/L, respectively. This showed that using PSB to treat PHWW can be an alternative method for PHWW nutrients recovery and pollutant treatment.