Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH‐Responsive Fe(III) Complex

A photo-stable and reversible pH-responsive phenazine dye displayed an obvious NIR absorption in a weak acid environment of tumor. The dye assembled into nanoparticles was developed for photoacoustic imaging-guided photothermal therapy in mice.

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Facile synthesis of polypyrrole@metal–organic framework core–shell nanocomposites for dual-mode imaging and synergistic chemo-photothermal therapy of cancer cells

Journal of Materials Chemistry B ◽

10.1039/c6tb03218d ◽

2017 ◽

Vol 5 (9) ◽

pp. 1772-1778 ◽

Cited By ~ 46

Author(s):

Xiangjun Chen ◽

Manjie Zhang ◽

Shengnan Li ◽

Lu Li ◽

Lingyu Zhang ◽

...

Keyword(s):

Magnetic Resonance ◽

Cancer Cells ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Metal Organic Framework ◽

Core Shell ◽

Dual Mode ◽

Facile Synthesis ◽

Metal Organic ◽

Facile Route

A facile route was developed to fabricate PPy@MOF for dual-mode magnetic resonance/photoacoustic imaging and synergistic chemo-photothermal therapy.

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Photothermal Therapy: pH-Responsive Fe(III)-Gallic Acid Nanoparticles for In Vivo Photoacoustic-Imaging-Guided Photothermal Therapy (Adv. Healthcare Mater. 7/2016)

Advanced Healthcare Materials ◽

10.1002/adhm.201670032 ◽

2016 ◽

Vol 5 (7) ◽

pp. 745-745 ◽

Cited By ~ 1

Author(s):

Jianfeng Zeng ◽

Ming Cheng ◽

Yong Wang ◽

Ling Wen ◽

Ling Chen ◽

...

Keyword(s):

Gallic Acid ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Ph Responsive

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Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

Biomaterials ◽

10.1016/j.biomaterials.2013.03.085 ◽

2013 ◽

Vol 34 (22) ◽

pp. 5651-5660 ◽

Cited By ~ 87

Author(s):

Hung-Wei Yang ◽

Hao-Li Liu ◽

Meng-Lin Li ◽

I-Wen Hsi ◽

Chih-Tai Fan ◽

...

Keyword(s):

Magnetic Resonance ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Gold Nanorod

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In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

RSC Advances ◽

10.1039/c7ra01879g ◽

2017 ◽

Vol 7 (30) ◽

pp. 18270-18276 ◽

Cited By ~ 6

Author(s):

Ming Cheng ◽

Wei Peng ◽

Peng Hua ◽

Zhengrong Chen ◽

Jia Sheng ◽

...

Keyword(s):

Prussian Blue ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Ph Responsive ◽

Background Signal ◽

Normal Tissues ◽

Theranostic Agent ◽

In Situ Formation

Dual pH-responsive theranostic agent reduces the background signal in photoacoustic imaging and non-specific heating of normal tissues in photothermal therapy.

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A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

Journal of Materials Chemistry B ◽

10.1039/c9tb00398c ◽

2019 ◽

Vol 7 (24) ◽

pp. 3856-3864 ◽

Cited By ~ 4

Author(s):

Mengxue Liu ◽

Jiulong Zhang ◽

Xin Li ◽

Chao Cai ◽

Xueyan Cao ◽

...

Keyword(s):

Iron Oxide ◽

Sialic Acid ◽

Magnetic Resonance ◽

Cancer Therapy ◽

Cancer Cells ◽

Photothermal Therapy ◽

Multimodal Imaging ◽

Photoacoustic Imaging

A novel targeted theranostic nanoplatform (LAP–Fe3O4@PDA–PEG–PBA) is constructed for magnetic resonance and photoacoustic imaging-guided photothermal therapy of cancer cells overexpressing sialic acid.

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Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring

Nanoscale ◽

10.1039/c8nr00044a ◽

2018 ◽

Vol 10 (13) ◽

pp. 5864-5868 ◽

Cited By ~ 9

Author(s):

Jing Ye ◽

Guifeng Fu ◽

Xiaohui Yan ◽

Jingyi Liu ◽

Xiaoyong Wang ◽

...

Keyword(s):

Magnetic Resonance ◽

Vascular Permeability ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Imaging Techniques ◽

Therapy Response ◽

Response Monitoring ◽

Combined Use

The combined use of magnetic resonance/photoacoustic imaging techniques is useful in monitoring vascular permeability and temperature status following nanoparticle-mediated photothermal therapy.

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Synthesis of Biomimetic Melanin-Like Multifunctional Nanoparticles for pH Responsive Magnetic Resonance Imaging and Photothermal Therapy

Nanomaterials ◽

10.3390/nano11082107 ◽

2021 ◽

Vol 11 (8) ◽

pp. 2107

Author(s):

Jing Qu ◽

Devin Guillory ◽

Pohlee Cheah ◽

Bin Tian ◽

Jie Zheng ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Photothermal Therapy ◽

Ph Responsive ◽

Resonance Imaging ◽

Multifunctional Nanoparticles ◽

Transmission Electron ◽

Weighted Magnetic Resonance Imaging ◽

Ft Ir ◽

Magnetic Resonance Imaging Mri

The design and development of multifunctional nanoparticles have attracted great interest in biomedical research. This study aims to prepare pH-responsive melanin-like nanoparticles for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy. The new multifunctional nanoparticles (amino-Fe-PDANPs) are synthesized by copolymerization of dopamine and its derivative amino-N-[2-(diethylamino) ethyl]-3,4-dihydroxy-benzenepropanamide (N-Dopa) at room temperature. The size of nanoparticles can be controlled by NaOH concentration. The incorporation of N-Dopa is characterized by NMR and FT-IR. From transmission electron microscopy (TEM), the nanoparticles exhibit excellent dispersion stability in water and are spherical in shape. The MRI measurement has demonstrated that amino-Fe-PDANPs have a significant signal enhancement in responding to the acidic solution. Confirmed by the photothermal study, the nanoparticles exhibit a high photothermal conversion efficiency. The melanin-like multifunctional nanoparticles integrate both diagnosis and therapeutic functionalities, indicating the potential for theranostic application.

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