Polydopamine Nanosheets Doped Injectable Hydrogel with Nitric Oxide Release and Photothermal Effects for Bacterial Ablation and Wound Healing

2021 ◽  
pp. 2101476
Author(s):  
Genhua Liu ◽  
Lu Wang ◽  
Ye He ◽  
Liucan Wang ◽  
Zhiwen Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Injectable Hydrogel ◽  
Nitric Oxide Release ◽  
Photothermal Effects

Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing

2018 ◽  
Vol 74 ◽  
pp. 312-325 ◽  
Author(s):  
Mathilde Champeau ◽  
Valéria Póvoa ◽  
Lucas Militão ◽  
Flávia M. Cabrini ◽  
Guilherme F. Picheth ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Nitric Oxide Release ◽  
Poly Acrylic Acid

scholarly journals Nitric Oxide Release from Antimicrobial Peptide Hydrogels for Wound Healing

Biomolecules ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 4 ◽  
Author(s):  
Joana Durão ◽  
Nuno Vale ◽  
Salomé Gomes ◽  
Paula Gomes ◽  
Cristina C. Barrias ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antimicrobial Peptide ◽  
Chronic Wounds ◽  
Dermal Fibroblasts ◽  
Initial Increase ◽  
No Donor ◽  
Collagen Production ◽  
Nitric Oxide Release ◽  
Lysine Residues

Nitric oxide (NO) is an endogenously produced molecule that has been implicated in several wound healing mechanisms. Its topical delivery may improve healing in acute or chronic wounds. In this study an antimicrobial peptide was synthesized which self-assembled upon a pH shift, forming a hydrogel. The peptide was chemically functionalized to incorporate a NO-donor moiety on lysine residues. The extent of the reaction was measured by ninhydrin assay and the NO release rate was quantified via the Griess reaction method. The resulting compound was evaluated for its antimicrobial activity against Escherichia coli, and its effect on collagen production by fibroblasts was assessed. Time-kill curves point to an initial increase in bactericidal activity of the functionalized peptide, and collagen production by human dermal fibroblasts when incubated with the NO-functionalized peptide showed a dose-dependent increase in the presence of the NO donor within a range of 0–20 μM.

Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing

2020 ◽  
Vol 20 ◽  
pp. 100781
Author(s):  
Huiling Liu ◽  
Xiaolan Zhu ◽  
Huiming Guo ◽  
Huanlei Huang ◽  
Shanghui Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Photothermal Therapy ◽  
Injectable Hydrogel
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