scholarly journals Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors

2008 ◽  
Vol 20 (9) ◽  
pp. 1671-1678 ◽  
Author(s):  
Xiangyang Shi ◽  
Su He Wang ◽  
Scott D. Swanson ◽  
Song Ge ◽  
Zhengyi Cao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine

2011 ◽  
Vol 111 (2) ◽  
pp. 253-280 ◽  
Author(s):  
Morteza Mahmoudi ◽  
Hossein Hosseinkhani ◽  
Mohsen Hosseinkhani ◽  
Sebastien Boutry ◽  
Abdolreza Simchi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Regenerative Medicine ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

scholarly journals T1-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 170 ◽  
Author(s):  
Cheng Tao ◽  
Qiang Zheng ◽  
Lu An ◽  
Meie He ◽  
Jiaomin Lin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Natural Protein ◽  
Liver And Kidney ◽  
Protein Macromolecule

To optimize the iron oxide nanoparticles as T1-weight contrast for in vivo magnetic resonance imaging (MRI), numbers of macromolecule ligands have been explored with considerable effort. However, reports refer to the comparison of the T1-weight contrast performances of iron oxide nanoparticles modified with natural and artificial macromolecule ligands are still limited. In this work, we used a typical natural protein macromolecule (bovine serum albumin, BSA) and an artificial macromolecule (poly(acrylic acid)-poly(methacrylic acid), PMAA-PTTM) as surface ligands to fabricate Fe3O4-BSA and Fe3O4-PMAA-PTTM nanoparticles with similar size and magnetization by the coprecipitation method and compared their MRI performances. In vitro and in vivo experiments revealed that Fe3O4-BSA with lower cytotoxicity exhibited higher r2/r1 ratio in solution and darkening contrast enhancement for liver and kidney sites of mice under T1-weight imaging, while Fe3O4-PMAA-PTTM displayed much lower r2/r1 ratio in solution and brighter contrast enhancement for liver and kidney sites. These remarkably different MRI behaviors demonstrated that the surface ligands play an important role for optimizing the MRI performance of Fe3O4 nanoparticles. We expect these results may facilitate the design of macromolecule ligands for developing an iron oxide–based T1-weight contrast agent.

Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: defining the structure and probing in vivo applications

Nanoscale ◽  
2016 ◽  
Vol 8 (19) ◽  
pp. 10078-10086 ◽  
Author(s):  
Alessandra Luchini ◽  
Carlo Irace ◽  
Rita Santamaria ◽  
Daniela Montesarchio ◽  
Richard K. Heenan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are performing contrast agents for Magnetic Resonance Imaging (MRI).

Targeted Superparamagnetic Iron Oxide Nanoparticles for In Vivo Magnetic Resonance Imaging of T-Cells in Rheumatoid Arthritis

2016 ◽  
Vol 19 (2) ◽  
pp. 233-244 ◽  
Author(s):  
Chih-Lung Chen ◽  
Tiing Yee Siow ◽  
Cheng-Hung Chou ◽  
Chen-Hsuan Lin ◽  
Ming-Huang Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
T Cells ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

scholarly journals High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles

2020 ◽  
Vol 6 (29) ◽  
pp. eabb0998 ◽  
Author(s):  
David E. J. Waddington ◽  
Thomas Boele ◽  
Richard Maschmeyer ◽  
Zdenka Kuncic ◽  
Matthew S. Rosen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
High Contrast ◽  
Resonance Imaging ◽  
Low Field

Magnetic resonance imaging (MRI) scanners operating at ultra-low magnetic fields (ULF; <10 mT) are uniquely positioned to reduce the cost and expand the clinical accessibility of MRI. A fundamental challenge for ULF MRI is obtaining high-contrast images without compromising acquisition sensitivity to the point that scan times become clinically unacceptable. Here, we demonstrate that the high magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) at ULF makes possible relaxivity- and susceptibility-based effects unachievable with conventional contrast agents (CAs). We leverage these effects to acquire high-contrast images of SPIONs in a rat model with ULF MRI using short scan times. This work overcomes a key limitation of ULF MRI by enabling in vivo imaging of biocompatible CAs. These results open a new clinical translation pathway for ULF MRI and have broader implications for disease detection with low-field portable MRI scanners.

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