Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS‐CoV‐2 Spike

<div>We report the synthesis of a novel macrocyclic host molecule that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine <i>N</i>-oxides based of the electron density of and steric bulk of the anionic oxygen.</div>

Download Full-text

Faculty Opinions recommendation of Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9722956.11583066 ◽

2011 ◽

Author(s):

Andrew D Sharrocks

Keyword(s):

Selective Binding ◽

Functional Roles

Download Full-text

Molecular mechanism of the cesium and rubidium selective binding to the calix[4]arene revealed by Born–Oppenheimer molecular dynamics simulation and electron density analysis

Mendeleev Communications ◽

10.1016/j.mencom.2021.03.013 ◽

2021 ◽

Vol 31 (2) ◽

pp. 185-187

Author(s):

Anna M. Kulakova ◽

Maria G. Khrenova

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Molecular Mechanism ◽

Electron Density ◽

Dynamics Simulation ◽

Selective Binding ◽

Density Analysis ◽

Electron Density Analysis

Download Full-text

Selective binding of Escherichia coli RNA polymerase to topoisomers of minicircles carrying the TAC16 and TAC17 promoters.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36861-8 ◽

1994 ◽

Vol 269 (18) ◽

pp. 13511-13521 ◽

Cited By ~ 2

Author(s):

T.T. Su ◽

W.R. McClure

Keyword(s):

Escherichia Coli ◽

Rna Polymerase ◽

Selective Binding

Download Full-text

P1-400: TAU AND ALPHA-SYNUCLEIN SELECTIVE BINDING COMPOUNDS DERIVED FROM APRINOIA THERAPEUTIC'S PM-PBB3 BINDING-SITE FOCUSED COMPOUND COLLECTION

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.408 ◽

2006 ◽

Vol 14 (7S_Part_8) ◽

pp. P455-P455

Author(s):

Paul Tempest ◽

Maiko Ono ◽

Makogto Higuchi ◽

Hitoshi Shimada ◽

Tetsuya Suhara ◽

...

Keyword(s):

Binding Site ◽

Alpha Synuclein ◽

Selective Binding ◽

Compound Collection

Download Full-text

Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment

Chemical Science ◽

10.1039/c7sc01905j ◽

2017 ◽

Vol 8 (9) ◽

pp. 6165-6170 ◽

Cited By ~ 19

Author(s):

A. Matsumoto ◽

A. J. Stephenson-Brown ◽

T. Khan ◽

T. Miyazawa ◽

H. Cabral ◽

...

Keyword(s):

Sialic Acid ◽

Boronic Acids ◽

Sialic Acids ◽

Strong Interactions ◽

Acidic Ph ◽

Acidic Environment ◽

Selective Binding ◽

High Affinity ◽

Ph Conditions ◽

Hypoxic Tumor

A group of heterocyclic boronic acids demonstrating unusually high affinity and selectivity for sialic acids are described, with strong interactions under the weakly acidic pH conditions associated with a hypoxic tumoral microenvironment.

Download Full-text