Towards Greener Fluorine Organic Chemistry: Direct Electrophilic Fluorination of Carbonyl Compounds in Water and Under Solvent-Free Reaction Conditions

2010 ◽  
Vol 352 (16) ◽  
pp. 2838-2846 ◽  
Author(s):  
Gaj Stavber ◽  
Stojan Stavber
Keyword(s):  
Organic Chemistry ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Electrophilic Fluorination ◽  
Solvent Free Reaction

Silicon-based thiourea-mediated and microwave-assisted thio-Michael addition under solvent-free reaction conditions

2011 ◽  
Vol 65 (5) ◽  
Author(s):  
Kamalakannan Prabakaran ◽  
Machindra Gund ◽  
Tae Kim ◽  
Euh Jeong ◽  
Chae Oh ◽  
...  
Keyword(s):  
Michael Addition ◽  
Carbonyl Compounds ◽  
Addition Reaction ◽  
Solvent Free ◽  
Michael Addition Reaction ◽  
Reaction Conditions ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Silicon Based ◽  
Solvent Free Reaction

AbstractSilicon-based thiourea (SiliaBond® Thiourea) (Si-THU), a heterogeneous catalyst, has been applied to the highly selective C-S bond formation via Michael addition of thiols to α,β-unsaturated carbonyl compounds under solvent-free conditions at 55–60°C. The thio-Michael addition products were obtained in an excellent yield under optimised conditions. This methodology involving a metal-free as well as a metal scavenger catalyst has been found to be an alternative method for the thio-Michael addition reaction.

Halogenation of ketones with N-halosuccinimides under solvent-free reaction conditions

Tetrahedron ◽  
2008 ◽  
Vol 64 (22) ◽  
pp. 5191-5199 ◽  
Author(s):  
Igor Pravst ◽  
Marko Zupan ◽  
Stojan Stavber
Keyword(s):  
Solvent Free ◽  
Reaction Conditions ◽  
Solvent Free Reaction

scholarly journals Silica sulfuric acid: a reusable solid catalyst for one pot synthesis of densely substituted pyrrole-fused isocoumarins under solvent-free conditions

2013 ◽  
Vol 9 ◽  
pp. 2344-2353 ◽  
Author(s):  
Sudipta Pathak ◽  
Kamalesh Debnath ◽  
Animesh Pramanik
Keyword(s):  
Sulfuric Acid ◽  
Low Cost ◽  
Solvent Free ◽  
Primary Amines ◽  
Solid Catalyst ◽  
Silica Sulfuric Acid ◽  
Reaction Conditions ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Solvent Free Reaction

A convenient and efficient methodology for the synthesis of densely substituted pyrrole-fused isocoumarins, which employs solid-supported silica sulfuric acid (SSA) as catalyst, has been developed. When the mixture of ninhydrin adducts of acetylacetone/ethyl acetoacetate and primary amines was heated on the solid surface of SSA under solvent-free conditions, the pyrrole-fused isocoumarins were formed in good yields. This synthetic method has several advantages such as the employment of solvent-free reaction conditions without the use of any toxic reagents and metal catalysts, the ease of product isolation, the use of a recyclable catalyst, the low cost, the easy availability of the starting materials, and the excellent yields of products.

scholarly journals N-Halosuccinimides as Precatalysts for C-, N-, O-, and X-Nucleophilic Substitution Reactions of Alcohols under Mild Reaction Conditions

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 460
Author(s):  
Njomza Ajvazi ◽  
Stojan Stavber
Keyword(s):  
Nucleophilic Substitution ◽  
Substrate Concentration ◽  
Solvent Free ◽  
Substitution Reactions ◽  
High Substrate Concentration ◽  
Reaction Conditions ◽  
High Substrate ◽  
Nucleophilic Substitution Reactions ◽  
Solvent Free Reaction

N-halosuccinimides (chloro, bromo, and iodo, respectively) were introduced, tested, and applied as efficient and non-metal precatalysts for C-, N-, O-, and X-nucleophilic substitution reactions of alcohols under solvent-free reaction conditions (SFRC) or under high substrate concentration reaction conditions (HCRC) efficiently and selectively, into the corresponding products.

scholarly journals Cyanuric Chloride-Catalyzed Michael Addition of Indoles to Nitroolefins under Solvent-Free Conditions

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Xiao Juan Yang ◽  
Yun Jing
Keyword(s):  
Michael Addition ◽  
Present Method ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Reaction Conditions ◽  
Experimental Procedure ◽  
Solvent Free Conditions ◽  
Short Period ◽  
The Michael Addition ◽  
Solvent Free Reaction

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the Michael addition of indoles to nitroolefins at 70°C under solvent-free conditions. The simple experimental procedure, solvent-free reaction conditions, utilization of an inexpensive and readily available catalyst, short period of conversion, and excellent yields are the advantages of the present method.

scholarly journals Asymmetric Michael Addition Organocatalyzed by α,β-Dipeptides under Solvent-Free Reaction Conditions

Molecules ◽  
2017 ◽  
Vol 22 (8) ◽  
pp. 1328 ◽  
Author(s):  
C. Gabriela Avila-Ortiz ◽  
Lenin Díaz-Corona ◽  
Erika Jiménez-González ◽  
Eusebio Juaristi
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Asymmetric Michael Addition ◽  
Solvent Free Reaction
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