Organocatalytic Hantzsch Type Reaction Using Aryl Hydrazines, Propiolic Acid Esters and Enals: Enantioselective Synthesis of Paroxetine

2020 ◽  
Vol 362 (23) ◽  
pp. 5385-5390
Author(s):  
Lu Chen ◽  
Zhi Zhang ◽  
Liansuo Zu
Keyword(s):  
Enantioselective Synthesis ◽  
Type Reaction ◽  
Propiolic Acid ◽  
Acid Esters

Enantioselective Synthesis of Pyroglutamic Acid Esters from Glycinate via Carbonyl Catalysis

2021 ◽  
Author(s):  
Baoguo Zhao ◽  
Jiguo Ma ◽  
Qinghai Zhou ◽  
Guanshui Song ◽  
Yongchang Song ◽  
...  
Keyword(s):  
Pyroglutamic Acid ◽  
Enantioselective Synthesis ◽  
Acid Esters

ChemInform Abstract: REACTION OF PROPIOLIC ACID ESTERS WITH DITHIOLS AND β-MERCAPTOETHANOL

1985 ◽  
Vol 16 (1) ◽  
Author(s):  
V. N. ELOKHINA ◽  
A. S. NAKHMANOVICH ◽  
R. V. KARNAUKHOVA ◽  
I. D. KALIKHMAN ◽  
O. B. BANNIKOVA
Keyword(s):  
Propiolic Acid ◽  
Acid Esters

Enantioselective synthesis of amino acid amides via enzymatic ammoniolysis of amino acid esters

1998 ◽  
Vol 5 (1-4) ◽  
pp. 155-157 ◽  
Author(s):  
M.A.P.J. Hacking ◽  
M.A. Wegman ◽  
J. Rops ◽  
F. van Rantwijk ◽  
R.A. Sheldon
Keyword(s):  
Amino Acid ◽  
Enantioselective Synthesis ◽  
Amino Acid Esters ◽  
Acid Esters

scholarly journals An Efficient and Mild Method for the Synthesis and Hydrazinolysis ofN-Glyoxylamino Acid Esters

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ayman El-Faham ◽  
Zainab Al Marhoon ◽  
Ahmed Abdel-Megeed ◽  
Mohamed Siddiqui
Keyword(s):  
Hydrazine Hydrate ◽  
Good Yield ◽  
Acid Ester ◽  
Ring Opening ◽  
Acid Hydrazide ◽  
Type Reaction ◽  
H Nmr ◽  
Elemental Microanalysis ◽  
Acid Esters ◽  
C Nmr

N-Glyoxylamino acid ester derivatives were synthesized via the ring opening ofN-acetylisatin using moderate conditions. During the hydrazinolysis ofN-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of theα-keto group occurred to affordN-acylamino acid hydrazide derivatives in good yield (80–90%) (Wolff-Kishner type reaction). All the synthesized compounds were characterized by1H NMR,13C NMR, and elemental microanalysis.

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