Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels

Traditional antibacterial hydrogels have a broad-spectrum bactericidal effect and are widely used as wound dressings. However, the biological toxicity and drug resistance of these antibacterial hydrogels cannot meet the requirements of long-term clinical application. Imidazolium poly(ionic liquids) (PILs) are polymeric antibacterial agents exhibiting strong antibacterial properties, as they contain a strong positive charge. In this study, two imidazolium PILs, namely poly(N-butylimidazolium propiolic acid sodium) (PBP) and poly(N-(3,6-dioxaoctane) imidazolium propiolic acid sodium) (PDP), as high efficiency antibacterial agents, were synthesized by polycondensation reaction. Then, the PILs were compounded with polyethylene glycol (PEG) by a thiol-yne click reaction to prepare injectable antibacterial hydrogels. An in vitro assay showed that the injectable antibacterial hydrogels could not only quickly kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), but also had low toxicity for human skin fibroblasts cells (HSFs) and human umbilical vein endothelial cells (HUVECs), respectively. Additionally, the lipopolysaccharide (LPS) inflammation model revealed that the injectable antibacterial hydrogels also had anti-inflammatory effects, which would be advantageous to accelerate wound healing.

CC-stretched formic acid: isomerisation, dimerisation, and carboxylic acid complexation

The cis–trans-isomerism of the propiolic acid monomer (HCC–COOH) is examined with linear Raman jet spectroscopy, yielding the first environment-free vibrational band centres of a higher-energy cis-rotamer beyond formic acid (HCOOH) in addition to all fundamentals and a large number of hot and combination/overtone bands of the trans-conformer.

Synthesis of indolizines from pyridinium 1,4-zwitterionic thiolates and propiolic acid derivatives via a formal [4 + 1] pathway

Indolizines were synthesized from 1,4-zwitterionic thiolates and propiolic acid derivatives mediated by triethylamine via a formal [4 + 1] pathway.

Palladium-catalyzed decarboxylative gem-selective addition of alkynoic acids to terminal alkynes

Alkynoic acids added to terminal alkynes to give gem-1,3-enynes with high selectivity and good yields. In addition, the reaction of alkynoic acids with propiolic acid provided the corresponding gem-1,3-enynes via double decarboxylation.

AgNPs encapsulated by an amine-functionalized polymer nanocatalyst for CO2 fixation as a carboxylic acid and the oxidation of cyclohexane under ambient conditions

A novel catalyst comprising Ag NPs grafted to a porous polystyrene material was synthesized for the production of valuable propiolic acid derivatives via CO2 (1 atm) incorporation, and the oxidation of cyclohexane under ambient reaction conditions.