Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

2012 ◽  
Vol 32 (S1) ◽  
pp. E486-E504 ◽  
Author(s):  
Ahmed S. Hussein ◽  
Norhafizah Abdullah ◽  
A. Fakru'l-razi
Keyword(s):  
Process Parameters ◽  
Double Emulsion ◽  
Plga Nanoparticles ◽  
Solvent Evaporation ◽  
Evaporation Technique

PLGA Nanoparticles for Anti Tuberculosis Drug Delivery

2012 ◽  
Vol 584 ◽  
pp. 465-469 ◽  
Author(s):  
S. Malathi ◽  
S. Balasubramanian
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Loading ◽  
Double Emulsion ◽  
Plga Nanoparticles ◽  
Release Mechanism ◽  
Sustained Drug Release ◽  
Drug Release Kinetics ◽  
Evaporation Technique

Nanoparticles-based drug delivery systems have considerable potential for the treatment of tuberculosis (TB). A series of PLGA polymers with different molar feed ratios (P2:87/13, P3:83/17, P5:63/37, P6:76/24, P9:53/47) were synthesized by direct melt poly condensation method. The resulting biodegradable polymers were characterized by FTIR and 1H NMR spectroscopy. The preparation of the drug (Pyrazinamide (PZA)) encapsulated PLGA polymers were carried out by double emulsion – solvent evaporation technique. The drug loaded PLGA-NPs were analyzed by UV-visible spectroscopy and scanning electron microscopy. The drug loading efficiency and drug release kinetics varies in the following order: P9>P5>P6>P3>P2. Among the formulations, PP9 showed a uniform as well as sustained drug release. The drug release kinetics has been evaluated by Zero-order, First order, Higuchi and Koresmeyer- Peppas models and the release mechanism has also been investigated

scholarly journals Dataset on controlled production of polyhydroxyalkanoate-based microbead using double emulsion solvent evaporation technique

Data in Brief ◽  
2019 ◽  
Vol 23 ◽  
pp. 103675 ◽  
Author(s):  
Sharumathiy Govindasamy ◽  
Ishak Muhammad Syafiq ◽  
Al-Ashraf Abdullah Amirul ◽  
Roswati Md Amin ◽  
Kesaven Bhubalan
Keyword(s):  
Double Emulsion ◽  
Solvent Evaporation ◽  
Evaporation Technique

Influence of Process Parameters on the Characteristics of Hydrophilic Drug-Loaded Microparticles through Double Emulsion Solvent Evaporation Technique

2019 ◽  
Vol 819 ◽  
pp. 252-257 ◽  
Author(s):  
Lalinthip Sutthapitaksakul ◽  
Pornsak Sriamornsak
Keyword(s):  
Process Parameters ◽  
Double Emulsion ◽  
Solvent Evaporation ◽  
Water Phase ◽  
Distilled Water ◽  
Influence Of Process Parameters ◽  
Hydrophilic Drug ◽  
Stirring Time ◽  
Primary Emulsion ◽  
Outer Water

The purpose of this study was to investigate the influence of process parameters on the characteristics of microparticles using double emulsion solvent evaporation method for encapsulation of hydrophilic drug. Donepezil hydrochloride (DPH), a reversible cholinesterase inhibitor, was selected as a model hydrophilic drug. Prior to conducting an experiment, the target particle size of microparticles was set at approximately 200 μm. The investigated process parameters include pH of outer water phase, stirring time, polymer amount, and volume of outer water phase. The results showed that DPH-loaded microparticles was successfully prepared in two steps. In the first step, the primary emulsion was prepared by dissolving DPH in distilled water before emulsifying in dichloromethane (DCM) containing different amounts of poly(butylmethacrylate-co-2-dimethylaminoethyl-methacrylate-co-methyl-methacrylate) (PBM-DM-MM) using ultrasonic probe. In the second step, the primary emulsion was emulsified in polyvinyl alcohol (PVA) solution by overhead stirrer to prepare double emulsion. After solvent evaporation, the microparticles were collected by centrifugation and washed with distilled water. Based on the statistical analysis, stirring time, polymer amount and volume of outer water phase were the main significant parameters influencing particle size of microparticles.

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