scholarly journals Water exchange across blood‐brain barrier is associated with CSF amyloid‐42 level in healthy older adults

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Brian T Gold ◽  
Xingfeng Shao ◽  
Danny JJ Wang
Keyword(s):  
Older Adults ◽  
Blood Brain Barrier ◽  
Water Exchange ◽  
Brain Barrier ◽  
Healthy Older Adults ◽  
Blood Brain

scholarly journals Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults

2021 ◽  
Author(s):  
Brian T. Gold ◽  
Xingfeng Shao ◽  
Tiffany L. Sudduth ◽  
Gregory A. Jicha ◽  
Donna M. Wilcock ◽  
...  
Keyword(s):  
Older Adults ◽  
Exchange Rate ◽  
Blood Brain Barrier ◽  
Water Exchange ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Water Exchange Rate ◽  
Healthy Older Adults ◽  
Blood Brain

scholarly journals Increase in blood–brain barrier leakage in healthy, older adults

GeroScience ◽  
2020 ◽  
Vol 42 (4) ◽  
pp. 1183-1193 ◽  
Author(s):  
Inge C. M. Verheggen ◽  
Joost J. A. de Jong ◽  
Martin P. J. van Boxtel ◽  
Ed H. B. M. Gronenschild ◽  
Walter M. Palm ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Healthy Older Adults ◽  
Blood Brain

scholarly journals Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218415 ◽  
Author(s):  
Yifan Zhang ◽  
Kui Xu ◽  
Yuchi Liu ◽  
Bernadette O. Erokwu ◽  
Pan Zhao ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Knockout Mice ◽  
Water Exchange ◽  
Aquaporin 4 ◽  
Brain Barrier ◽  
Blood Brain

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

2018 ◽  
Vol 14 (12) ◽  
pp. 1640-1650 ◽  
Author(s):  
Gene L. Bowman ◽  
Loïc Dayon ◽  
Richard Kirkland ◽  
Jérôme Wojcik ◽  
Gwendoline Peyratout ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown

Proteomes of Paired Human Cerebrospinal Fluid and Plasma: Relation to Blood–Brain Barrier Permeability in Older Adults

2019 ◽  
Vol 18 (3) ◽  
pp. 1162-1174 ◽  
Author(s):  
Loïc Dayon ◽  
Ornella Cominetti ◽  
Jérôme Wojcik ◽  
Antonio Núñez Galindo ◽  
Aikaterini Oikonomidi ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Human Cerebrospinal Fluid ◽  
Blood Brain ◽  
Brain Barrier Permeability

scholarly journals Blood‐based multi‐omic signatures of blood‐brain barrier impairment and CSF‐defined Alzheimer disease in older adults

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Christopher Clark ◽  
Gene L. Bowman ◽  
Loic Dayon ◽  
Frederic Raymond ◽  
Jerome Wojcik ◽  
...  
Keyword(s):  
Older Adults ◽  
Alzheimer Disease ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Valerie C. Anderson ◽  
David P. Lenar ◽  
Joseph F. Quinn ◽  
William D. Rooney
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Water Exchange ◽  
Vascular Dysfunction ◽  
The Elderly ◽  
Brain Barrier ◽  
Critical Function ◽  
Functional Changes ◽  
Blood Brain

Alzheimer's disease (AD) is the most common form of dementia in the elderly. Although traditionally considered a disease of neurofibrillary tangles and amyloid plaques, structural and functional changes in the microvessels may contribute directly to the pathogenesis of the disease. Since vascular dysfunction often precedes cognitive impairment, understanding the role of the blood-brain barrier (BBB) in AD may be key to rational treatment of the disease. We propose that water regulation, a critical function of the BBB, is disturbed in AD and results in abnormal permeability and rates of water exchange across the vessel walls. In this paper, we describe some of the pathological events that may disturb microvascular water exchange in AD and examine the potential of a relatively new imaging technique, dynamic contrast-enhanced MRI, to quantify water exchange on a cellular level and thus serve as a probe of BBB integrity in AD.

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