Impact of intrathecal cell therapy with autologous stromal cells on short‐term memory binding in early Alzheimer’s disease: One‐year follow‐up assessment

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Sara Fernández Guinea ◽  
Mercedes Zurita ◽  
Jorge Mucientes ◽  
Estefanía García ◽  
Javier González Marqués ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Therapy ◽  
Stromal Cells ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Early Alzheimer’S Disease ◽  
One Year

scholarly journals P3-013: PRELIMINARY EVIDENCE OF THE IMPACT OF INTRATHECAL CELL THERAPY WITH AUTOLOGOUS STROMAL CELLS ON SHORT-TERM MEMORY BINDING IN EARLY ALZHEIMER'S DISEASE CASES

2019 ◽  
Vol 15 ◽  
pp. P929-P929
Author(s):  
Sara Fernández Guinea ◽  
Mercedes Zurita ◽  
Jorge Mucientes ◽  
Estefanía García ◽  
Mario Alfredo Parra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Therapy ◽  
Stromal Cells ◽  
Short Term Memory ◽  
Preliminary Evidence ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Early Alzheimer’S Disease ◽  
The Impact

scholarly journals Visual short-term memory binding deficits in Alzheimer's disease: a reply to Parra's commentary.

Cortex ◽  
2017 ◽  
Vol 88 ◽  
pp. 201-204 ◽  
Author(s):  
Yuying Liang ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Susie M.D. Henley ◽  
Sebastian Crutch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding

scholarly journals Short-term memory binding deficits in Alzheimer's disease

Brain ◽  
2008 ◽  
Vol 132 (4) ◽  
pp. 1057-1066 ◽  
Author(s):  
M. A. Parra ◽  
S. Abrahams ◽  
K. Fabi ◽  
R. Logie ◽  
S. Luzzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

scholarly journals Visual short-term memory binding in Alzheimer’s disease and depression

2010 ◽  
Vol 257 (7) ◽  
pp. 1160-1169 ◽  
Author(s):  
Mario A. Parra ◽  
Sharon Abrahams ◽  
Robert H. Logie ◽  
Sergio Della Sala
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding

scholarly journals Specific deficit of colour–colour short-term memory binding in sporadic and familial Alzheimer's disease

2011 ◽  
Vol 49 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Mario A. Parra ◽  
Sergio Della Sala ◽  
Sharon Abrahams ◽  
Robert H. Logie ◽  
Luis Guillermo Méndez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Memory Binding ◽  
Familial Alzheimer's Disease

scholarly journals Visual short-term memory binding deficit in familial Alzheimer's disease

Cortex ◽  
2016 ◽  
Vol 78 ◽  
pp. 150-164 ◽  
Author(s):  
Yuying Liang ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Susie M.D. Henley ◽  
Sebastian Crutch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding ◽  
Familial Alzheimer's Disease

Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer’s disease continuum

2021 ◽  
Vol 152 ◽  
pp. 105749
Author(s):  
Mario Amore Cecchini ◽  
Mônica Sanches Yassuda ◽  
Paula Squarzoni ◽  
Artur Martins Coutinho ◽  
Daniele de Paula Faria ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Amyloid Deposition ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Brain Amyloid Deposition

scholarly journals Oculomotor Behaviors and Integrative Memory Functions in the Alzheimer’s Clinical Syndrome

2021 ◽  
pp. 1-12
Author(s):  
Gerardo Fernández ◽  
Mario A. Parra
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Eye Tracking ◽  
Short Term Memory ◽  
Clinical Syndrome ◽  
Biological Information ◽  
Healthy Controls ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

Background: Biological information drawn from eye-tracking metrics is providing evidence regarding drivers of cognitive decline in Alzheimer’s disease. In particular, pupil size has proved useful to investigate cognitive performance during online activities. Objective: To investigate the oculomotor correlates of impaired performance of patients with mild Alzheimer’s Clinical Syndrome (ACS) on a recently developed memory paradigm, namely the Short-Term Memory Binding Test (STMBT). Methods: We assessed a sample of eighteen healthy controls (HC) and eighteen patients with a diagnosis of mild ACS with the STMBT while we recorded their oculomotor behaviors using pupillometry and eye-tracking. Results: As expected, a group (healthy controls versus ACS) by condition (Unbound Colours versus Bound Colours) interaction was found whereby behavioral group differences were paramount in the Bound Colours condition. Healthy controls’ pupils dilated significantly more in the Bound Colours than in the Unbound Colours condition, a discrepancy not observed in ACS patients. Furthermore, ROC analysis revealed the abnormal pupil behaviors distinguished ACS patients from healthy controls with values of sensitivity and specify of 100%, thus outperforming both recognition scores and gaze duration. Conclusion: The biological correlates of Short-Term Memory Binding impairments appear to involve a network much wider than we have thought to date, which expands across cortical and subcortical structures. We discuss these findings focusing on their implications for our understanding of neurocognitive phenotypes in the preclinical stages of Alzheimer’s disease and potential development of cognitive biomarkers that can support ongoing initiatives to prevent dementia.

scholarly journals Visual Processing during Short-Term Memory Binding in Mild Alzheimer’s Disease

2018 ◽  
Vol 63 (1) ◽  
pp. 185-194 ◽  
Author(s):  
Gerardo Fernández ◽  
David Orozco ◽  
Osvaldo Agamennoni ◽  
Marcela Schumacher ◽  
Silvana Sañudo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Processing ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding
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