scholarly journals Anti‐inflammation as one of the mechanisms in the improvement of cognitive function by probiotic Bifidobacterium breve strain

2021 ◽  
Vol 17 (S9) ◽  
Author(s):  
Kazuya Ohno ◽  
Francois Bernier ◽  
Noriko Katsumata ◽  
Takashi Shimizu ◽  
Jin‐Zhong Xiao
Keyword(s):  
Cognitive Function ◽  
Bifidobacterium Breve ◽  
Anti Inflammation

BIFIDOBACTERIUM BREVE A1 SUPPLEMENTATION IMPROVED COGNITIVE DECLINE IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: AN OPEN-LABEL, SINGLE-ARM STUDY

2018 ◽  
pp. 1-6
Author(s):  
Y. Kobayashi ◽  
T. Kinoshita ◽  
A. Matsumoto ◽  
K. Yoshino ◽  
I. Saito ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Mental Condition ◽  
Rank Tests ◽  
Open Label ◽  
Bifidobacterium Breve ◽  
Signed Rank

Objectives: We previously reported the therapeutic potential of Bifidobacterium breve A1 (B. breve A1) for preventing cognitive impairment in Alzheimer’s disease model mice, which suggested that supplementation of the probiotics could be an effective therapeutic strategy for managing cognitive function in mild cognitive impairment (MCI). Design and settings: We conducted an open-label, single-arm study to examine the effects of 24-week supplementation of B. breve A1 on elderly with MCI in Aki Orthopedics Rehabilitation Clinic in Japan. Participants: 27 participants were screened by their Mini Mental State Examination (MMSE) scores. Measurements: Cognitive function was assessed using MMSE and Digit Symbol Substitution Test (DSST) at baseline and every 8 weeks. Mental condition and quality of life for gastrointestinal symptoms were measured using the Profile of Mood States 2nd Edition (POMS2), and the Gastrointestinal Symptom Rating Scale (GSRS). Results: Of the 27 participants enrolled, 19 completed the study. MMSE scores were significantly increased during the intervention by mixed model Dunnett’s test and Wilcoxon signed-rank tests (+1.7, P < 0.01). POMS2 and GSRS scores were significantly improved during intervention when analyzed by Wilcoxon signed-rank tests. Conclusion: The present study showed that oral supplementation of B. breve A1 in participants with MCI improved cognitive function, thus suggesting the potential of B. breve A1 for improving cognitive function and maintaining quality of life of the elderly. Further randomized, double-blind placebo-controlled studies are worth conducting to examine the beneficial effect of B. breve A1.

scholarly journals Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment

2021 ◽  
pp. 1-5
Author(s):  
Francois Bernier ◽  
Kazuya Ohno ◽  
Noriko Katsumata ◽  
Takashi Shimizu ◽  
Jinzhong Xiao
Keyword(s):  
Inverse Correlation ◽  
Probiotic Strain ◽  
Blood Parameters ◽  
Probiotic Supplementation ◽  
Double Blind ◽  
Bifidobacterium Breve ◽  
Plasma Hemoglobin ◽  
Stratified Analysis ◽  
Controlled Clinical Study ◽  
Anti Inflammation

We demonstrated the benefit of the probiotic strain, Bifidobacterium breve MCC1274 (synonym B. breve A1), at improving cognition in our previous double-blind, placebo-controlled clinical study. Analysis of the association of blood parameters changes with the improvement of cognitive function revealed an inverse correlation of HbA1c with total RBANS score amelioration after the study only in the probiotic group (ρ= –0. 4218, p = 0.0067). A stratified analysis based on baseline HbA1c with a median value showed a more remarkable benefit by the probiotic supplementation in the higher median subgroup. These data support the mechanism of anti-inflammation in improving cognition by the probiotic strain.

Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial

2019 ◽  
Vol 10 (5) ◽  
pp. 511-520 ◽  
Author(s):  
Y. Kobayashi ◽  
T. Kuhara ◽  
M. Oki ◽  
J.-Z. Xiao
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Controlled Trial ◽  
Elderly Subjects ◽  
Probiotic Supplementation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Bifidobacterium Breve ◽  
Memory Complaints ◽  
With Memory

In our previous study, we reported the therapeutic potential of Bifidobacterium breve A1 in preventing cognitive impairment in a mouse model of Alzheimer’s disease and participants with mild cognitive impairment; we suggested that probiotic supplementation is an effective therapeutic strategy for managing cognitive function. Accordingly, we conducted a randomised, double-blind, placebo-controlled trial to assess whether 12-week B. breve A1 supplementation could affect the cognitive function of elderly subjects with memory complaints. We assessed cognitive function using the Japanese version of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Mini-Mental State Examination (MMSE) at baseline and after 12 weeks of probiotic supplementation. A total of 121 participants were randomised and received B. breve A1 capsules or placebo daily for 12 weeks; of these, 117 participants completed the study. At 12 weeks, neuropsychological test scores significantly increased in both groups; no significant intergroup difference was observed in terms of changes in scores from the baseline scores. However, a stratified analysis revealed a significant difference between B. breve A1 and placebo groups in terms of the subscale ‘immediate memory’ of RBANS and MMSE total score in the subjects with low RBANS total score at baseline. No significant differences in terms of blood parameters between the groups or adverse effects caused by B. breve A1 intervention were observed. The results of the present study suggest the safety of B. breve A1 supplementation and its potential in maintaining cognitive function in elderly subjects with memory complaints. However, future large-scale studies on individuals with impaired cognitive function are required to validate the present findings.

Effects of a Group Program to Increase Cognitive Performance Through Cognitively Stimulating Leisure Activities in Healthy Older Subjects

GeroPsych ◽  
2011 ◽  
Vol 24 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Valentina A. Tesky ◽  
Christian Thiel ◽  
Winfried Banzer ◽  
Johannes Pantel
Keyword(s):  
Cognitive Function ◽  
Cognitive Performance ◽  
Older Persons ◽  
Intervention Program ◽  
Leisure Activities ◽  
The Elderly ◽  
Cognitive Stimulation ◽  
Group Program ◽  
Positive Effects ◽  
Older Subjects

To investigate the effects of leisure activities on cognitive performance of healthy older subjects, an innovative intervention program was developed. Frequent participation in cognitively stimulating activities (i.e., reading, playing chess, or playing music) is associated with reduced risk of dementia. AKTIVA (active cognitive stimulation – prevention in the elderly) is an intervention program designed to enhance cognitive stimulation in everyday life by increasing cognitive stimulating leisure activities. The present study determines the effects of AKTIVA on cognitive function, mood and attitude toward aging in a sample of older participants from the general population. Several measurement instruments were used including the Alzheimer’s Disease Assessment Scale (ADAS-Cog), the Trail-Making Test (TMT), and the Memory Complaint Questionnaire (MAC-Q). Initially, the sample consisted of 307 older persons (170 female, 72 ± 7 years). The intervention was evaluated with a randomized, controlled pre-post follow-up design. Participants were randomly assigned to one of three conditions: AKTIVA intervention (n = 126), AKTIVA intervention plus nutrition and exercise counseling (n = 84), no-intervention control group (n = 97). The AKTIVA intervention consisted of 8 weekly sessions and two booster sessions after a break of 4 months. Participation in the group program resulted in positive effects on cognitive function and attitude toward aging for subassembly groups. Older persons (≥ 75 years) showed enhanced speed of information processing (by TMT Version A) (F = 4.17*, p < .05); younger participants (< 75 years) showed an improvement in subjective memory decline (by MAC-Q) (F = 2.55*, p < .05). Additionally, AKTIVA enhanced the frequency of activities for leisure activities for subassembly groups. The results of this study suggest that the AKTIVA program can be used to increase cognitively stimulating leisure activities in the elderly. Further research is necessary to identify the long-term effects of this intervention particularly with respect to the prevention of dementia.

Hydration and Cognitive Function in Older Adults With Cardiovascular Disease

2008 ◽  
Author(s):  
John Gunstad ◽  
Mary B. Spitznagel ◽  
Kelly Stanek ◽  
Faith Luyster ◽  
James Rosneck ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Cognitive Function
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