Quantitative systems pharmacology model of amyloid and tau to explore efficacy of therapy targeting modified forms of amyloid

Modified Forms ◽

Dynamical systems analysis as an additional tool to inform treatment outcomes: The case study of a quantitative systems pharmacology model of immuno-oncology

Chaos An Interdisciplinary Journal of Nonlinear Science ◽

10.1063/5.0022238 ◽

2021 ◽

Vol 31 (2) ◽

pp. 023124

Author(s):

Aymen Balti ◽

Didier Zugaj ◽

Frédérique Fenneteau ◽

Pierre-Olivier Tremblay ◽

Fahima Nekka

Keyword(s):

Dynamical Systems ◽

Treatment Outcomes ◽

Systems Analysis ◽

Systems Pharmacology ◽

Additional Tool ◽

Dynamical Systems Analysis ◽

Quantitative systems pharmacology model of thrombopoiesis and platelet life‐cycle, and its application to thrombocytopenia based on chronic liver disease

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12623 ◽

2021 ◽

Author(s):

Ryosuke Shimizu ◽

Takayuki Katsube ◽

Toshihiro Wajima

Keyword(s):

Life Cycle ◽

Liver Disease ◽

Chronic Liver Disease ◽

Chronic Liver ◽

Systems Pharmacology ◽

A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor

The AAPS Journal ◽

10.1208/s12248-020-00450-3 ◽

2020 ◽

Vol 22 (4) ◽

Cited By ~ 4

Author(s):

Huilin Ma ◽

Hanwen Wang ◽

Richard J. Sove ◽

Mohammad Jafarnejad ◽

Chia-Hung Tsai ◽

...

Keyword(s):

T Cell ◽

Solid Tumor ◽

Systems Pharmacology ◽

A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.119.260539 ◽

2019 ◽

Vol 372 (3) ◽

pp. 299-307

Author(s):

Violeta Balbas-Martinez ◽

Eduardo Asin-Prieto ◽

Zinnia P. Parra-Guillen ◽

Iñaki F. Troconiz

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Systems Pharmacology ◽

Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®

The AAPS Journal ◽

10.1208/s12248-019-0348-4 ◽

2019 ◽

Vol 21 (4) ◽

Author(s):

Alison Betts ◽

Nahor Haddish-Berhane ◽

Dhaval K. Shah ◽

Piet H. van der Graaf ◽

Frank Barletta ◽

...

Keyword(s):

T Cell ◽

Tumor Cell ◽

Cell Killing ◽

Systems Pharmacology ◽

Tumor Cell Killing ◽

Abstract A70: Bridging nonclinical studies to clinical design using quantitative systems pharmacology model of T cell-engaging bispecifics

10.1158/2326-6074.tumimm19-a70 ◽

2020 ◽

Author(s):

Lin Lin ◽

Lucia Wille ◽

Alison Betts ◽

Fei Hua ◽

David Hagen ◽

...

Keyword(s):

T Cell ◽

Systems Pharmacology ◽

P2-147: DESCRIPTION OF DIFFERENT AMYLOID TOXIC SPECIES AND PATHOLOGY PROGRESSION BY MECHANISTIC QUANTITATIVE SYSTEMS PHARMACOLOGY MODEL

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.833 ◽

2006 ◽

Vol 14 (7S_Part_13) ◽

pp. P724-P725

Author(s):

Tatiana Karelina ◽

Alena Zhukova

Keyword(s):

Systems Pharmacology ◽

Toxic Species ◽

Quantitative systems pharmacology model of Alzheimer’s disease to study efficacy of combinatorial therapy on multiple pathology components

Alzheimer s & Dementia ◽

10.1002/alz.042695 ◽

2020 ◽

Vol 16 (S9) ◽

Author(s):

Tatiana Karelina

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Systems Pharmacology ◽

Combinatorial Therapy ◽

Multiple Pathology ◽

Model Of Alzheimer’S Disease ◽

A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance

Frontiers in Pharmacology ◽

10.3389/fphar.2014.00229 ◽

2014 ◽

Vol 5 ◽

Cited By ~ 11

Author(s):

Athan Spiros ◽

Patrick Roberts ◽

Hugo Geerts

Keyword(s):

Negative Symptoms ◽

Systems Pharmacology ◽

Computer Based ◽

Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

Alzheimer s Research & Therapy ◽

10.1186/s13195-018-0343-5 ◽

2018 ◽

Vol 10 (1) ◽

Cited By ~ 14

Author(s):

Hugo Geerts ◽

Athan Spiros ◽

Patrick Roberts

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trials ◽

Amyloid Beta ◽

Cognitive Outcomes ◽

Systems Pharmacology ◽

Disease Analysis ◽