Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women

Abstract Background Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. Methods Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. Results There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26–3.44], women (aOR = 2.06, 95% CI: 1.35–3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34–7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69–6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17–4.61) than normal BMI group. Conclusions Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.

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Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women

Obstetrical & Gynecological Survey ◽

10.1097/ogx.0b013e3182439f33 ◽

2012 ◽

Vol 67 (1) ◽

pp. 34-36 ◽

Cited By ~ 1

Author(s):

Kristine Yaffe ◽

Alison M. Laffan ◽

Stephanie Litwack Harrison ◽

Susan Redline ◽

Adam P. Spira ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Older Women ◽

Sleep Disordered Breathing ◽

Disordered Breathing

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Operationalizing the Diagnostic Criteria for Mild Cognitive Impairment: The Salience of Objective Measures in Predicting Incident Dementia

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2016.12.012 ◽

2017 ◽

Vol 25 (5) ◽

pp. 485-497 ◽

Cited By ~ 13

Author(s):

Henry Brodaty ◽

Liesbeth Aerts ◽

John D. Crawford ◽

Megan Heffernan ◽

Nicole A. Kochan ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Diagnostic Criteria ◽

Objective Measures ◽

Incident Dementia

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Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women

Journal of the American Geriatrics Society ◽

10.1111/jgs.14552 ◽

2016 ◽

Vol 65 (3) ◽

pp. 511-519 ◽

Cited By ~ 10

Author(s):

Erin S. LeBlanc ◽

Joanne H. Rizzo ◽

Kathryn L. Pedula ◽

Kristine Yaffe ◽

Kristine E. Ensrud ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Older Women

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Treatment for mild cognitive impairment: systematic review

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.127811 ◽

2013 ◽

Vol 203 (4) ◽

pp. 255-264 ◽

Cited By ~ 108

Author(s):

Claudia Cooper ◽

Ryan Li ◽

Constantine Lyketsos ◽

Gill Livingston

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Group Intervention ◽

Cholinesterase Inhibitors ◽

National Football League ◽

Life Quality ◽

Preliminary Evidence ◽

Jewish Federation ◽

Incident Dementia ◽

Randomised Controlled

BackgroundMore people are presenting with mild cognitive impairment (MCI), frequently a precursor to dementia, but we do not know how to reduce deterioration.AimsTo systematically review randomised controlled trials (RCTs) evaluating the effects of any intervention for MCI on cognitive, neuropsychiatric, functional, global outcomes, life quality or incident dementia.MethodWe reviewed 41 studies fitting predetermined criteria, assessed validity using a checklist, calculated standardised outcomes and prioritised primary outcome findings in placebo-controlled studies.ResultsThe strongest evidence was that cholinesterase inhibitors did not reduce incident dementia. Cognition improved in single trials of: a heterogeneous psychological group intervention over 6 months; piribedil, a dopamine agonist over 3 months; and donepezil over 48 weeks. Nicotine improved attention over 6 months. There was equivocal evidence that Huannao Yicong improved cognition and social functioning.ConclusionsThere was no replicated evidence that any intervention was effective. Cholinesterase inhibitors and rofecoxib are ineffective in preventing dementia. Further good-quality RCTs are needed and preliminary evidence suggests these should include trials of psychological group interventions and piribedil.Declarations of interestC.L. has received grant support (research or continuing medical education) from NIMH, NIA, Associated Jewish Federation of Baltimore, Weinberg Foundation, Forest, GlaxoSmithKline, Eisai, Pfizer, AstraZeneca, Lilly, Ortho-McNeil, Bristol-Myers Squibb, Novartis, National Football League (NFL), Elan, Functional Neuromodulation; and has been a consultant/advisor to AstraZeneca, GlaxoSmithKline, Eisai, Novartis, Forest, Supernus, Adlyfe, Takeda, Wyeth, Lundbeck, Merz, Lilly, Pfizer, Genentech, Elan, NFL Players Association, NFL Benefits Office, Avanir, Zinfandel, Bristol-Myers Squibb; and received honorarium or travel support from Pfizer, Forest, GlaxoSmithKline, Health Monitor.

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