scholarly journals Alzheimer disease family history impacts resting state functional connectivity

2012 ◽  
Vol 72 (4) ◽  
pp. 571-577 ◽  
Author(s):  
Liang Wang ◽  
Catherine M. Roe ◽  
Abraham Z. Snyder ◽  
Matthew R. Brier ◽  
Jewell B. Thomas ◽  
...  
Keyword(s):  
Family History ◽  
Functional Connectivity ◽  
Alzheimer Disease ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Disease Family

Contributions from resting state functional connectivity and familial risk to early adolescent-onset MDD: Results from the Adolescent Brain Cognitive Development study

2020 ◽  
Author(s):  
Yuqi Cai ◽  
Nourhan Elsayed ◽  
Deanna Barch
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Development ◽  
Family History ◽  
Functional Connectivity ◽  
Resting State ◽  
Familial Risk ◽  
Early Adolescent ◽  
Resting State Functional Connectivity ◽  
Development Study ◽  
Risk For Depression

Background: Family history of Major Depressive Disorder (MDD) is a robust predictor of MDD onset, especially in early adolescence. We examined the relationships between familial risk for depression and alterations to resting state functional connectivity (rsFC) within the default mode network (DMN), and between the DMN and the left/right hippocampus (DMN-LHIPP/RHIPP) to the risk for early adolescent MDD onset. Methods: We examined 9403 youth aged nine to eleven from the Adolescent Brain Cognitive Development Study. Depressive symptoms were measured with the parent-reported Child Behavior Checklist. Both youth and their parents completed the Kiddie Schedule for Affective Disorders and Schizophrenia, which provided MDD diagnoses. A family history screen was administered to determine familial risk for depression. Youth underwent a resting state functional magnetic resonance imaging scan, providing us with rsFC data. Results: Lower wDMN rsFC was associated with child-reported current and both child- and parent-reported current depressive symptoms and past MDD diagnosis. No difference was found in wDMN or DMN-LHIPP/RHIPP rsFC in children with or without familial risk for depression. Familial risk for depression interacted with wDMN rsFC to predict child-reported past MDD diagnosis and parent-reported current depressive symptoms.Limitations: Information such as length of depressive episodes and age of onset of depression was not collected.Conclusions: Altered wDMN rsFC in youth at familial risk for depression could confer increased risk for MDD onset in adolescence. This finding helps illuminate a potential mechanism by which family history contributes to greater risk for early MDD onset.

Resting-State Functional Connectivity Changes Associated with Visuospatial Cognitive Deficits in Patients with Mild Alzheimer Disease

2017 ◽  
Vol 43 (5-6) ◽  
pp. 229-236 ◽  
Author(s):  
Rakesh Balachandar ◽  
Srikala Bharath ◽  
John P. John ◽  
Himanshu Joshi ◽  
Shilpa Sadanand ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Alzheimer Disease ◽  
Cognitive Deficits ◽  
Resting State ◽  
Neurodegenerative Disorder ◽  
Functional Neuroimaging ◽  
Brain Connectivity ◽  
Resting State Functional Connectivity ◽  
Total Brain Volume ◽  
Visual Network

Background/Aims: Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive disconnection of various brain networks leading to neuropsychological impairment. Pathology in the visual association areas has been documented in presymptomatic AD and therefore we aimed at examining the relationship between brain connectivity and visuospatial (VS) cognitive deficits in early AD. Methods: Tests for VS working memory, episodic memory and construction were used to classify patients with AD (n = 48) as having severe VS deficits (n = 12, female = 4) or mild deficits (n = 11, female = 4). Resting-state functional magnetic resonance imaging and structural images were acquired as per the standard protocols. Between-group differences in resting-state functional connectivity (rsFC) were examined by dual regression analysis correcting for age, gender, and total brain volume. Results: Patients with AD having severe VS deficits exhibited significantly reduced rsFC in bilateral lingual gyri of the visual network compared to patients with mild VS deficits. Conclusion: Reduced rsFC in the visual network in patients with more severe VS deficits may be a functional neuroimaging biomarker reflecting hypoconnectivity of the brain with progressive VS deficits during early AD.

Relating Disinhibited Eating Behaviors to Resting State Functional Connectivity in Young Children

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1889-P
Author(s):  
ALLISON L.B. SHAPIRO ◽  
SUSAN L. JOHNSON ◽  
BRIANNE MOHL ◽  
GRETA WILKENING ◽  
KRISTINA T. LEGGET ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Young Children ◽  
Resting State ◽  
Eating Behaviors ◽  
Resting State Functional Connectivity ◽  
Disinhibited Eating
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