Suppressor T-lymphocytes in multiple sclerosis: Analysis of patients with acute relapsing and chronic progressive disease

AbstractIntroduction: Multiple Sclerosis (MS) is a chronic progressive disease of the nervous system which etiology is still unknown. Environmental factors, genetic predisposition and complex autoimmune reactions play a significant role in its pathogenesis. MS is not a fatal disease, but patients often require constant medical care and complex social welfare. Physiotherapy conducted at every stage of the disease depends on the current state of a patient and their functional capability and gradually occurring disorders and dysfunctions. Physical therapy is an important element of the therapy.Aim: To evaluate the usefulness of physical treatments used in the treatment of the MS patients.Material and methods: An analysis of domestic and foreign literature published between 2004 and 2014. The following databases were searched: PubMed, Science Direct, Termedia, Polish Medical Bibliography, Cochrane. The papers concerning the use of physical treatment as monotherapy and combination therapy were included.Summary and conclusions: Numerous research confirm both safety and efficacy of physical methods used in treatment of the MS patients. The implementation of research on the mechanism of action and effectiveness of physical factors, which are well-designed in terms of methodology, allows for the selection of the optimal physical procedure. Modern equipment and current methods of physiotherapy change views on the previously used treatments, their methodology and application.

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CSF Myelin Basic Protein Levels in Acute Optic Neuritis and Multiple Sclerosis

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100045066 ◽

1983 ◽

Vol 10 (4) ◽

pp. 235-238 ◽

Cited By ~ 18

Author(s):

K.G. Warren ◽

Ingrid Catz ◽

T.A. McPherson

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Myelin Basic Protein ◽

Progressive Disease ◽

Basic Protein ◽

Internuclear Ophthalmoplegia ◽

Protein Levels ◽

Acute Optic Neuritis ◽

Chronic Progressive Disease

SUMMARY:Normal CSF-MBP levels as determined by a RIA were <6.2 ng/ml CSF (mean 3.9). Eighty percent of patients with acute optic neuritis have CSF-MBP levels greater than 6.2 ng/ml (mean 7.6 ng/ml CSF). Five of 7 patients with acute internuclear ophthalmoplegia due to an initial exacerbation of demyelination have CSF-MBP levels above 6.2 ng/ml (mean 6.8 ng/ml). Fifty percent of MS patients with chronic progressive disease have CSF-MBP levels above 6.2 ng/ml (mean 6.7 ng/ml). MS patients experiencing monosymptomatic exacerbations show elevated CSF-MBP levels in 75% of cases (mean 8.2 ng/ml). MS patients experiencing polysymptomatic exacerbations show significantly higher levels of CSF-MBP (mean 22.3 ng/ml) than the patients with monosymptomatic exacerbations. Ninety-five percent of MS patients experiencing polysymptomatic exacerbations have elevated levels of CSF-MBP.

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Тhе genetic epidemiology of multiple sclerosis

Neurology Bulletin ◽

10.17816/nb78865 ◽

2000 ◽

Vol XXXII (1-2) ◽

pp. 81-81

Author(s):

A. Compston

Keyword(s):

Multiple Sclerosis ◽

Nervous System ◽

Peripheral Nervous System ◽

Genetic Epidemiology ◽

Progressive Disease ◽

Multiple Lesions ◽

Chronic Progressive Disease

Multiple sclerosis is a chronic progressive disease of the nervous system, proceeding with exacerbations and remissions, or steadily progressively, with multiple lesions in the central and peripheral nervous system.

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Interleukin-12 is detectable in sera of patients with multiple sclerosis - association with chronic progressive disease course?

European Journal of Neurology ◽

10.1046/j.1468-1331.1999.650591.x ◽

1999 ◽

Vol 6 (5) ◽

pp. 591-596 ◽

Cited By ~ 15

Author(s):

Christoph Heesen ◽

Frank Sieverding ◽

Benedikt Gustav Heinrich Schoser ◽

Bijan Hadji ◽

Klaus Kunze

Keyword(s):

Multiple Sclerosis ◽

Progressive Disease ◽

Interleukin 12 ◽

Disease Course ◽

Chronic Progressive Disease

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MANAGMENT OF MULTIPLE SCLEROSIS THROUGH THE RAY OF AYURVEDIC PRINCIPLE: A CASE STUDY

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj3709042021 ◽

2021 ◽

Vol 9 (4) ◽

pp. 904-908

Author(s):

Mukta Mukta ◽

Manjula Karlwad

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Stem Cell ◽

Immune Cells ◽

Progressive Disease ◽

Autoimmune Disorders ◽

Sensory Deficits ◽

Chronic Progressive Disease

Autoimmune disease occurs when the immune system attacks self-molecules as a result of a breakdown of immu- nological tolerance to auto reactive immune cells. Autoimmune disorders are on the rise globally and affect 8.5% of the population worldwide. In that one among is Multiple Sclerosis (MS)2 is a chronic progressive disease with a variety of cognitive, motor and sensory deficits. In Ayurveda, Multiple Sclerosis can be correlated to Pranaavruta Vyana3, all autoimmune diseases are the result of Amavisha and ama utpatti.4 Modern treatments like immuno- suppressant, corticosteroids, stem cell therapy are highly expensive when compared to Ayurvedic management. The scope of Ayurvedic Management and preventive aspect mainly concentrates on Ama Pachana, Agni Deepana, Doshavashechana, Shesha Dosha Shamana and followed by Rasayana, which in turn improves the quality of life and life expectancy. Keywords: Autoimmune disorders, Multiple Sclerosis, Pranaavruta Vyana, Ama

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Features of the course and treatment of glaucoma during pregnancy

Clinical Medicine (Russian Journal) ◽

10.30629/0023-2149-2020-98-3-178-184 ◽

2020 ◽

Vol 98 (3) ◽

pp. 178-184

Author(s):

T. V. Chernyakova ◽

A. Yu. Brezhnev ◽

I. R. Gazizova ◽

A. V. Kuroyedov ◽

A. V. Seleznev

Keyword(s):

Pregnant Women ◽

Laser Treatment ◽

Progressive Disease ◽

Clinical Course ◽

The Other ◽

Third Trimester ◽

The Third ◽

Chronic Progressive Disease ◽

Hypotensive Therapy ◽

Eye Pressure

In the review we have integrated all up-to-date knowledge concerning clinical course and treatment of glaucoma among pregnant women to help specialists choose a proper policy of treatment for such a complicated group of patients. Glaucoma is a chronic progressive disease. It rarely occurs among childbearing aged women. Nevertheless the probability to manage pregnant patients having glaucoma has been recently increasing. The situation is complicated by the fact that there are no recommendations on how to treat glaucoma among pregnant women. As we know, eye pressure is progressively going down from the first to the third trimester, so we often have to correct hypotensive therapy. Besides, it is necessary to take into account the effect of applied medicines on mother health and evaluate possible teratogenic complications for a fetus. The only medicine against glaucoma which belongs to category B according to FDA classification is brimonidine. Medicines of the other groups should be prescribed with care. Laser treatment or surgery may also be a relevant decision when monitoring patients who are planning pregnancy or just bearing a child. Such treatment should be also accompanied by medicines.

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Transplantation Reviews, Volume 26: Suppressor T. Lymphocytes. Edited by Goran Moller, M.D.; 1975. Copenhagen: Munksgaard. 9i'x6*, pp. 206. Price: D.kr.113.00.

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1976.tb140919.x ◽

1962 ◽

Vol 1 (17) ◽

pp. 633

Keyword(s):

T Lymphocytes ◽

Suppressor T Lymphocytes

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Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

Antioxidants ◽

10.3390/antiox10010021 ◽

2020 ◽

Vol 10 (1) ◽

pp. 21

Author(s):

Anna Signorile ◽

Anna Ferretta ◽

Maddalena Ruggieri ◽

Damiano Paolicelli ◽

Paolo Lattanzio ◽

...

Keyword(s):

Oxidative Stress ◽

Multiple Sclerosis ◽

T Lymphocytes ◽

Main Role ◽

Apoptosis Resistance ◽

Nutraceutical Compounds ◽

Camp Pathway ◽

Central Nervous Systems ◽

Genetic And Environmental Factors

Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial dysfunction, and oxidative stress exert a role in the alteration of T lymphocytes homeostasis and are involved in the apoptosis resistance of immune cells with the consequent development of autoimmune diseases. The defective apoptosis of autoreactive lymphocytes in patients with MS, allows these cells to perpetuate, within the CNS, a continuous cycle of inflammation. In this review, we discuss the involvement in MS of cAMP pathway, mitochondria, reactive oxygen species (ROS), apoptosis, and their interaction in the alteration of T lymphocytes homeostasis. In addition, we discuss a series of nutraceutical compounds that could influence these aspects.

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