On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 125 (16) ◽  
pp. 4480-4484 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
2013 ◽  
Vol 52 (16) ◽  
pp. 4384-4388 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  

2018 ◽  
Vol 6 (15) ◽  
pp. 2258-2273 ◽  
Author(s):  
F. R. Cheng ◽  
T. Su ◽  
J. Cao ◽  
X. L. Luo ◽  
Li Li ◽  
...  

Limited active sites in polyesters hinder fabrication of multifunctional biodegradable nanocarriers for successful clinical applications.


2016 ◽  
Vol 87 ◽  
pp. 60-66 ◽  
Author(s):  
Otávio M. Gil ◽  
Michele A. Rocha ◽  
Vera R.L. Constantino ◽  
Ivan H.J. Koh ◽  
Dalva L.A. de Faria

2019 ◽  
Vol 43 (14) ◽  
pp. 5404-5413 ◽  
Author(s):  
Phuong Thu Ha ◽  
Thi Thu Huong Le ◽  
Thuc Quang Bui ◽  
Hong Nam Pham ◽  
Anh Son Ho ◽  
...  

Multifunctional nanosystems help to control drug release and highly improve the cancer treatment efficacy in in vivo models.


2019 ◽  
Vol 303 ◽  
pp. 281-288 ◽  
Author(s):  
Kohei Matsumoto ◽  
Shin-ichiro Kimura ◽  
Shigeru Itai ◽  
Hiromu Kondo ◽  
Yasunori Iwao

Langmuir ◽  
2012 ◽  
Vol 29 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Lidong Zhang ◽  
Young-Il Jeong ◽  
Sudan Zheng ◽  
Hongsuk Suh ◽  
Dae Hwan Kang ◽  
...  

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.


ACS Omega ◽  
2020 ◽  
Author(s):  
Shaoxin Deng ◽  
Cheng-Xing Cui ◽  
Lingyao Duan ◽  
Linfeng Hu ◽  
Xiaoxun Yang ◽  
...  

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