scholarly journals Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo‐Dynamic Therapy

Author(s):  
Jan van Hest ◽  
Shoupeng Cao ◽  
Yifeng Xia ◽  
Jingxin Shao ◽  
Beibei Guo ◽  
...  
2018 ◽  
Vol 08 (04) ◽  
pp. 024-027
Author(s):  
Shiny Inasu ◽  
Biju Thomas

AbstractA novel noninvasive photochemical approach for infection control, namely photodynamic therapy, has received much attention in the treatment of oral diseases which requires three nontoxic ingredients namely visible harmless light, a photosensitizer and oxygen are involved in this therapy. It is based on the principle that a photosensitizer binds to the target cells which when activated by light of a suitable wavelength results in the production of singlet oxygen and other very reactive agents that are extremely toxic to certain cells and bacteria. This article highlights the application of photo-dynamic therapy in management of periodontal disease and its current status.


2017 ◽  
Vol 7-8 ◽  
pp. 46-51
Author(s):  
Leila Karami-Gadallo ◽  
Mahmood Ghoranneviss ◽  
Leila Ataie-Fashtami ◽  
Majid Pouladian ◽  
Dariush Sardari

2013 ◽  
Vol 12 (1) ◽  
pp. e600
Author(s):  
S. Agrawal ◽  
E. Havrenak ◽  
D. Hrouda ◽  
A. Shamsuddin

Urology ◽  
1997 ◽  
Vol 50 (2) ◽  
pp. 199-206 ◽  
Author(s):  
McClellan M. Walther ◽  
Thomas F. Delaney ◽  
Paul D. Smith ◽  
Walter S. Friauf ◽  
Gunter F. Thomas ◽  
...  

2021 ◽  
Author(s):  
Stefano Perni ◽  
Emily Preedy ◽  
Polina Prokopovich

Abstract Light-activated antimicrobial agents (photosensitisers) are promising alternatives to antibiotics for the treatment of skin infections and wounds through antimicrobial Photo Dynamic Therapy (aPDT); utilisation of this technique is still restricted by general low efficacy requiring long exposure time (in the order of tens of minutes) that make the treatment very resource intensive. We report for the first time the possibility of harvesting the cell penetrating properties of poly-beta-amino esters (PBAEs) in combination with toluidine blue O (TBO) to shorten aPDT exposure time. Candidates capable of inactivation rates 30 times quicker than pure TBO were discovered and further improvements through PBAE backbone optimisation could be foreseen. Efficacy of the complexes was PBAE-dependent on a combination of TBO uptake and a newly discovered and unexpected role of PBAEs on reactive species production. Chemometric approach of partial least square regression was employed to assess the critical PBAE properties involved in this newly observed phenomenon in order to elicit a possible mechanism.The superior antimicrobial performance of this new approach benefits from the use of well established, low-cost and safe dye (TBO) coupled with inexpensive, widely tested and biodegradable polymers also known to be safe. Moreover, no adverse cytotoxic effects of the PBAEs adjuvated TBO delivery have been observed on a skin cells in vitro model demonstrating the safety profile of this new technology.


1986 ◽  
Vol 6 (3) ◽  
pp. 77-80
Author(s):  
Yusuke Kuroda ◽  
Hiroto Kuroda ◽  
Yuichi Tanaka ◽  
Yoshihiko Kanemitsu ◽  
Tadayoshi Takemoto ◽  
...  

2016 ◽  
Vol 37 (4) ◽  
pp. 134-139
Author(s):  
Deog Su Choi ◽  
Hyun Soo Lim ◽  
Byung Koo Lee ◽  
Necla Kenar

2010 ◽  
Author(s):  
G. Berkovitch ◽  
A. Nudelman ◽  
B. Ehenberg ◽  
A. Rephaeli ◽  
Z. Malik ◽  
...  

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