scholarly journals Vimentin Intermediate Filaments: the Central Base in Sinus Endothelial Cells of the Rat Spleen

2010 ◽  
Vol 293 (12) ◽  
pp. 2034-2043 ◽  
Author(s):  
Kiyoko Uehara ◽  
Akira Uehara
Keyword(s):  
Endothelial Cells ◽  
Intermediate Filaments ◽  
Sinus Endothelial Cells ◽  
Central Base

scholarly journals Fine Structure of the Red Pulp of the Spleen in Hereditary Spherocytosis

Blood ◽  
1972 ◽  
Vol 39 (1) ◽  
pp. 81-98 ◽  
Author(s):  
ZELMA MOLNAR ◽  
HENRY RAPPAPORT
Keyword(s):  
Endothelial Cells ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Hereditary Spherocytosis ◽  
Probable Mechanism ◽  
Hemoglobin Content ◽  
Sinus Endothelial Cells ◽  
In Transit ◽  
Conventional Light Microscopy ◽  
Red Pulp

Abstract The spleens from two children and one adult with hereditary spherocytosis were studied in the electron microscope. Stagnation of the erythrocytes within the splenic cords is attributable to their lack of plasticity as evidenced by the absence of bilobed, tailed, or squeezed forms in transit through the walls of the sinuses. In contrast to the sections studied by conventional light microscopy, the splenic sinuses in hereditary spherocytosis were not "empty," but contained red blood cells, the majority of which had lost their hemoglobin content. Cordal macrophages were increased in all three cases and were abundant in the splenic cords of the adult patient, causing a further impediment to the rapid passage of erythrocytes. Macrophages, and, to a lesser degree, sinus endothelial cells contained the products of hemoglobin breakdown. The macrophages showed active erythrophagocytosis. Sinus endothelial cells rarely contained intact red blood cells, but showed pronounced pinocytotic activity, a probable mechanism of hemoglobin incorporation. Platelets within the endothelial cells of the sinuses were much more frequently seen in the three cases of hereditary spherocytosis than in control spleens. The presence of ferritin in platelets suggests that they too may play a role in clearing the end products of hemolysis from the spleen.

Tubular invaginations with caveolae and coated pits in the sinus endothelial cells of the rat spleen

1999 ◽  
Vol 112 (5) ◽  
pp. 351-358 ◽  
Author(s):  
K. Uehara ◽  
Masayuki Miyoshi
Keyword(s):  
Endothelial Cells ◽  
Coated Pits ◽  
Sinus Endothelial Cells

The surface-connected canalicular system in the sinus endothelial cells of rat spleen

1999 ◽  
Vol 296 (2) ◽  
pp. 439 ◽  
Author(s):  
K. Uehara ◽  
Masayuki Miyoshi
Keyword(s):  
Endothelial Cells ◽  
Sinus Endothelial Cells

Junctions between the sinus endothelial cells of rat spleen

1996 ◽  
Vol 287 (1) ◽  
pp. 187-192 ◽  
Author(s):  
Kiyoko Uehara ◽  
Masayuki Miyoshi
Keyword(s):  
Endothelial Cells ◽  
Sinus Endothelial Cells

Localization of ryanodine receptor 3 in the sinus endothelial cells of the rat spleen

2004 ◽  
Vol 317 (2) ◽  
Author(s):  
Kiyoko Uehara ◽  
Hitoshi Onoue ◽  
LoiceH. Jeyakumar ◽  
Sidney Fleischer ◽  
Akira Uehara
Keyword(s):  
Endothelial Cells ◽  
Ryanodine Receptor ◽  
Sinus Endothelial Cells

Localization of TRPC1 channel in the sinus endothelial cells of rat spleen

2005 ◽  
Vol 123 (4-5) ◽  
pp. 347-356 ◽  
Author(s):  
Kiyoko Uehara
Keyword(s):  
Endothelial Cells ◽  
Sinus Endothelial Cells ◽  
Trpc1 Channel

Identification of microfilaments in marrow sinus endothelial cells: Their possible role in cell egress

1981 ◽  
Vol 74 (3) ◽  
pp. 255-258 ◽  
Author(s):  
Makoto Aoki ◽  
Mehdi Tavassoli
Keyword(s):  
Endothelial Cells ◽  
Sinus Endothelial Cells

scholarly journals Microtubules and the endoplasmic reticulum are highly interdependent structures.

1986 ◽  
Vol 103 (4) ◽  
pp. 1557-1568 ◽  
Author(s):  
M Terasaki ◽  
L B Chen ◽  
K Fujiwara
Keyword(s):  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Intermediate Filaments ◽  
Vascular Endothelial Cells ◽  
Staining Technique ◽  
Vascular Endothelial ◽  
Extended State ◽  
Short Term ◽  
Dye Staining ◽  
Prolonged Absence

The interrelationships of the endoplasmic reticulum (ER), microtubules, and intermediate filaments were studied in the peripheral regions of thin, spread fibroblasts, epithelial, and vascular endothelial cells in culture. We combined a fluorescent dye staining technique to localize the ER with immunofluorescence to localize microtubules or intermediate filaments in the same cell. Microtubules and the ER are sparse in the lamellipodia, but intermediate filaments are usually completely absent. These relationships indicate that microtubules and the ER advance into the lamellipodia before intermediate filaments. We observed that microtubules and tubules of the ER have nearly identical distributions in lamellipodia, where new extensions of both are taking place. We perturbed microtubules by nocodazole, cold temperature, or hypotonic shock, and observed the effects on the ER distribution. On the basis of our observations in untreated cells and our experiments with microtubule perturbation, we conclude that microtubules and the ER are highly interdependent in two ways: (a) polymerization of individual microtubules and extension of individual ER tubules occur together at the level of resolution of the fluorescence microscope, and (b) depolymerization of microtubules does not disrupt the ER network in the short term (15 min), but prolonged absence of microtubules (2 h) leads to a slow retraction of the ER network towards the cell center, indicating that over longer periods of time, the extended state of the entire ER network requires the microtubule system.

scholarly journals Fc-mediated binding of IgG to vimentin-type intermediate filaments in vascular endothelial cells.

1984 ◽  
Vol 81 (10) ◽  
pp. 3103-3107 ◽  
Author(s):  
G. K. Hansson ◽  
G. A. Starkebaum ◽  
E. P. Benditt ◽  
S. M. Schwartz
Keyword(s):  
Endothelial Cells ◽  
Intermediate Filaments ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Type Intermediate
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