Estrogen and Insulin Replacement Therapy Modulates the Expression of Insulin-Like Growth Factor-I Receptors in the Salivary Glands of Diabetic Mice

2011 ◽  
Vol 294 (11) ◽  
pp. 1930-1938 ◽  
Author(s):  
Monica Hayashi Yashida ◽  
Ana Luyza Domingues Da Silva Faria ◽  
Eduardo José Caldeira
Keyword(s):  
Growth Factor ◽  
Replacement Therapy ◽  
Salivary Glands ◽  
Insulin Like Growth Factor ◽  
Diabetic Mice ◽  
Factor I ◽  
Growth Factor I ◽  
Insulin Replacement

The insulin-like growth factor-I system and hormone replacement therapy

2001 ◽  
Vol 75 (2) ◽  
pp. 282-287 ◽  
Author(s):  
Hilton José Pereira Cardim ◽  
Ceci Mendes Carvalho Lopes ◽  
Daniel Giannella-Neto ◽  
Angela Maggio da Fonseca ◽  
José Aristodemo Pinotti
Keyword(s):  
Hormone Replacement Therapy ◽  
Growth Factor ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Oral administration of insulin-like growth factor-I from colostral whey reduces blood glucose in streptozotocin-induced diabetic mice

2011 ◽  
Vol 108 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Kyung-A Hwang ◽  
Yu-Jin Hwang ◽  
Woelkyu Ha ◽  
Young-Kug Choo ◽  
Kisung Ko
Keyword(s):  
Blood Glucose ◽  
Growth Factor ◽  
Oral Administration ◽  
Insulin Like Growth Factor ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Factor I ◽  
Blood Glucose Levels ◽  
Igf I ◽  
Growth Factor I

The aim of the present study was to investigate the effects of oral administration of the insulin-like growth factor-I-rich fraction (IGF-I-RF) from bovine colostral whey on the regulation of blood glucose levels in streptozotocin (STZ)-induced diabetic mice. We obtained a peptide fraction containing IGF-I (10 ng/mg protein) from Holstein colostrum within 24 h after parturition by using ultrafiltration. The blood glucose levels of STZ-induced diabetic mice fed with IGF-I-RF (50 μg/kg per d) were significantly reduced by 11 and 33 % at weeks 2 and 4, respectively (P < 0·05). The body weights of STZ-induced diabetic mice increased following the oral administration of the IGF-I-RF. The kidney weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of the IGF-I-RF, and the liver weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of 50 μg/kg per d of the IGF-I-RF. The present results indicate that the IGF-I-RF obtained from Holstein colostrum could be a useful component for an alternative therapeutic modality for the treatment of diabetes in insulin-resistant patients.

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