The role of cell surface proteins in platelet stimulation by monosodium urate crystals

Sexual reproduction is such a successful way of creating progeny with subtle genetic variations that the vast majority of eukaryotic species use it. In mammals, it involves the formation of highly specialised cells: the sperm in males and the egg in females, each carrying the genetic inheritance of an individual. The interaction of sperm and egg culminates with the fusion of their cell membranes, triggering the molecular events that result in the formation of a new genetically distinct organism. Although we have a good cellular description of fertilisation in mammals, many of the molecules involved remain unknown, and especially the identity and role of cell surface proteins that are responsible for sperm–egg recognition, binding, and fusion. Here, we will highlight and discuss these gaps in our knowledge and how the role of some recently discovered sperm cell surface and secreted proteins contribute to our understanding of this fundamental process.

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The role of cell surface proteins gene expression in diagnosis, prognosis, and drug resistance of colorectal cancer: In silico analysis and validation

Experimental and Molecular Pathology ◽

10.1016/j.yexmp.2021.104688 ◽

2021 ◽

Vol 123 ◽

pp. 104688

Author(s):

Nasrin Nazempour ◽

Mohammad Hossein Taleqani ◽

Navid Taheri ◽

Amir Hossein Haji Ali Asgary Najafabadi ◽

Alireza Shokrollahi ◽

...

Keyword(s):

Gene Expression ◽

Colorectal Cancer ◽

Drug Resistance ◽

Cell Surface ◽

In Silico ◽

In Silico Analysis ◽

Surface Proteins ◽

Cell Surface Proteins ◽

Silico Analysis

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The role of glycosyl phosphatidyl inositol (GPI)-anchored cell surface proteins in T-cell activation

Transplant Immunology ◽

10.1016/s0966-3274(02)00013-8 ◽

2002 ◽

Vol 9 (2-4) ◽

pp. 93-96 ◽

Cited By ~ 41

Author(s):

Rolf Loertscher ◽

Paula Lavery

Keyword(s):

T Cell ◽

Cell Surface ◽

T Cell Activation ◽

Cell Activation ◽

Phosphatidyl Inositol ◽

Surface Proteins ◽

Cell Surface Proteins

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Could MicroRNAs be Regulators of Gout Pathogenesis?

Cellular Physiology and Biochemistry ◽

10.1159/000430176 ◽

2015 ◽

Vol 36 (6) ◽

pp. 2085-2092 ◽

Cited By ~ 7

Author(s):

Yangang Wang ◽

Donghua Xu ◽

Bin Wang ◽

Xu Hou

Keyword(s):

Inflammatory Arthritis ◽

Inflammatory Diseases ◽

Gouty Arthritis ◽

Noncoding Rnas ◽

Monosodium Urate ◽

Regulate Gene Expression ◽

Acute Gouty Arthritis ◽

Monosodium Urate Crystals ◽

Urate Crystals

MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout.

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Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside

Vaccines ◽

10.3390/vaccines8010041 ◽

2020 ◽

Vol 8 (1) ◽

pp. 41

Author(s):

Gabriel Siracusano ◽

Maria Tagliamonte ◽

Luigi Buonaguro ◽

Lucia Lopalco

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Surface ◽

Intracellular Signaling ◽

Surface Proteins ◽

Signaling Proteins ◽

Cell Surface Proteins ◽

Neoplastic Diseases ◽

Extracellular Environment

Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.

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