Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: A comparative study with fibromyalgia and rheumatoid arthritis

Research has shown hypermobility Ehlers–Danlos syndrome (hEDS) to be associated with some complicated rheumatologic disease. In this feature paper, the authors discuss the prevalence and pathophysiology of rheumatologic conditions, specifically ankylosing spondylitis and rheumatoid arthritis, in patients with hEDS. Furthermore, the authors discuss possible reasons for the association of hEDS with these rheumatologic diseases.

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Joint capsule collagen. Analysis by the study of intra-articular pressure during joint distension. Measurements in the knees of control subjects and patients with rheumatoid arthritis and Ehlers-Danlos syndrome.

Annals of the Rheumatic Diseases ◽

10.1136/ard.30.5.481 ◽

1971 ◽

Vol 30 (5) ◽

pp. 481-486 ◽

Cited By ~ 3

Author(s):

G Steer ◽

M I Jayson ◽

A S Dixon ◽

P Beighton

Keyword(s):

Rheumatoid Arthritis ◽

Joint Capsule ◽

Ehlers Danlos Syndrome ◽

Control Subjects ◽

Danlos Syndrome ◽

Collagen Analysis

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Autonomic symptom burden in the hypermobility type of Ehlers–Danlos syndrome: A comparative study with two other EDS types, fibromyalgia, and healthy controls

Seminars in Arthritis and Rheumatism ◽

10.1016/j.semarthrit.2014.05.013 ◽

2014 ◽

Vol 44 (3) ◽

pp. 353-361 ◽

Cited By ~ 38

Author(s):

Inge De Wandele ◽

Patrick Calders ◽

Wim Peersman ◽

Steven Rimbaut ◽

Tine De Backer ◽

...

Keyword(s):

Comparative Study ◽

Symptom Burden ◽

Healthy Controls ◽

Ehlers Danlos Syndrome ◽

Autonomic Symptom ◽

Danlos Syndrome

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FM1-7 Cranio-cervical instability in ehlers-danlos syndrome employing upright, dynamic MR imaging; a comparative study

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2019-abn.69 ◽

2019 ◽

Vol 90 (3) ◽

pp. e22.2-e22

Author(s):

GK Prezerakos ◽

F Khan ◽

I Davagnanam ◽

F Smith ◽

AT Casey

Keyword(s):

Mr Imaging ◽

Comparative Study ◽

Structural Features ◽

Control Group ◽

List Type ◽

Ehlers Danlos Syndrome ◽

Axial Angle ◽

Dynamic Mr Imaging ◽

Danlos Syndrome ◽

Dynamic Mr

ObjectivesEhlers-Danlos syndrome (EDS) is a hereditary connective tissue disorder leading to hypemobile joints including the craniocervical junction. Neck pain is a prominent feature. Structural abnormalities may have a dynamic element and thus may not be captured in a recumbent MRI. There is currently a lack of evidence1 assessing the use and diagnostic impact of positional MRI in Ehlers-Danlos syndrome. We aim to evaluate structural features and dynamic instability in an EDS cohort employing dynamic MR imaging against a non EDS symptomatic cohort.DesignComparative Study.SubjectsPatients diagnosed with Ehlers-Danlos syndrome and control subjects (non EDS with cervical spondylosis) were included in this study.MethodsCranio – cervical spine global and segmental movement parameters in the neutral, extension and flexion positions were measured from T2-weighted images in the midline sagittal plane. These parameters included the clivo axial angle, grabb oakes line, C2 sagittal vertical axis, C0-C1 angle, C1-2 angle, cervical lordosis and T1 slope.ResultsThe clivo- axial angle measured in neutral was 139.7±10.4 degrees in the EDS group vs 148.9±8.4 in the control group (p<0.01) The cervical range of movement between flexion and extension was 74.6±24.4 in the EDS group vs 39.4±11.3 in the controls (p<0.0001).ConclusionsEDS patients with neck symptoms exhibit different static as well as dynamic craniocervical structural features compared to a general population control.ReferenceOnt Health Technol Assess Ser [Internet]2015July;15(13):1–24.

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Subacromial space outlet in female patients with multidirectional instability based on hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder measured by ultrasound

Journal of Shoulder and Elbow Surgery ◽

10.1016/j.jse.2019.08.003 ◽

2020 ◽

Vol 29 (3) ◽

pp. 600-608 ◽

Cited By ~ 1

Author(s):

Birgitte Hougs Kjær ◽

Inge de Wandele ◽

Valentien Spanhove ◽

Birgit Juul-Kristensen ◽

Ann M. Cools

Keyword(s):

Spectrum Disorder ◽

Subacromial Space ◽

Ehlers Danlos Syndrome ◽

Female Patients ◽

Multidirectional Instability ◽

Danlos Syndrome

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Musculoskeletal disorders

10.1093/med/9780198713333.003.0046 ◽

2016 ◽

Author(s):

James P. R. Brown ◽

M. Joanne Douglas

Keyword(s):

Rheumatoid Arthritis ◽

Ankylosing Spondylitis ◽

Osteogenesis Imperfecta ◽

Musculoskeletal Disorders ◽

Musculoskeletal Diseases ◽

Musculoskeletal Condition ◽

Ehlers Danlos Syndrome ◽

Obstetric Anaesthesia ◽

Management Plans ◽

Danlos Syndrome

This chapter describes the major musculoskeletal diseases stating manifestations, associations, and their implications for pregnancy, delivery, and obstetric anaesthesia. It reviews and summarizes the literature, presenting the available evidence for methods of mitigating risks to the parturient. The chapter starts by discussing the pathophysiology, presentation, diagnosis, and management of malignant hyperthermia. The following conditions are then introduced in turn: backache, scoliosis, myopathies (including myotonic dystrophy), Ehlers–Danlos syndrome, rheumatoid arthritis, ankylosing spondylitis, achondroplasia, and osteogenesis imperfecta. The chapter aims to provide a pragmatic resource to allow obstetric anaesthetists to make informed decisions and management plans when faced with caring for a parturient with an uncommon musculoskeletal condition.

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