Relation between absorption half-life values of four novel sustained-release dosage forms of valproic acid in dogs and human

1986 ◽  
Vol 7 (5) ◽  
pp. 495-500 ◽  
Author(s):  
Meir Bialer ◽  
Michael Friedman ◽  
Joseph Dubrovsky
Keyword(s):  
Valproic Acid ◽  
Sustained Release ◽  
Half Life ◽  
Dosage Forms ◽  
Life Values

Pharmacokinetic evaluation of novel sustained-release dosage forms of valproic acid in humans

1985 ◽  
Vol 6 (4) ◽  
pp. 401-411 ◽  
Author(s):  
Meir Bialer ◽  
Michael Friedman ◽  
Joseph Dubrovsky ◽  
Itamar Raz ◽  
Oded Abramsky
Keyword(s):  
Valproic Acid ◽  
Sustained Release ◽  
Dosage Forms ◽  
Pharmacokinetic Evaluation

Development and Characterization of LBG-PVA Interpenetrating Networks Incorporating Gliclazide for Sustained Release

2020 ◽  
Vol 15 ◽  
Author(s):  
Ashish Katoch ◽  
Manju Nagpal ◽  
Malkiet Kaur ◽  
Manjinder Singh ◽  
Geeta Aggarwal ◽  
...  
Keyword(s):  
Solid State ◽  
Sustained Release ◽  
Half Life ◽  
Solid State Nmr ◽  
Oral Dosage ◽  
Cross Linking ◽  
Interpenetrating Networks ◽  
Dsc Studies ◽  
Biological Half Life ◽  
Percentage Yield

Background: Controlled oral dosage forms have always been preferred for drugs with variable absorption, and short biological half life and frequent dosing. The prime goal with sustained release systems is to maintain uniform therapeutic blood levels for longer periods of time. Interpenetrating networks (IPNs) have been evidenced as uniform sustained release systems. In current study, polyvinyl alcohol (PVA) and locust bean gum (LBG) based IPNs were developed for the oral sustained release drug delivery of gliclazide (shows variable absorption). Method: The IPNs were synthesized by emulsion cross-linking method using glutaraldehyde (GA) as a cross linking agent. Gliclazide is a potential second generation, short-acting sulfonylurea oral hypoglycemic agent is having a short biological half-life (2-4 h), variable absorption and poor oral bioavailability. Various batches of IPNs were formulated by varying LBG: PVA ratio and evaluated for percentage yield, drug entrapment efficiency (DEE), swelling properties and in vitro drug release studies. Further characterizations were done by Fourier Transform Infrared Spectroscopy (FTIR), C13 Solid state NMR, X-Ray diffraction study (XRD), Scanning electron microscopy (SEM), and Differential scanning microscopy (DSC) studies. Results: The percentage yield, drug entrapment and equilibrium swelling was observed to be dependent on PVA-LBG ratio and GA amount. Sustained release of drug was observed in all IPN formulations (approx 59 - 86% in 8 h in various batches) with variable release kinetics. SEM studies revealed the regular structures of IPNs. FTIR, XRD, C13 Solid state NMR and DSC studies proposed that drug was successfully incorporated into the formed IPNs. Conclusion: IPNs of LBG and PVA can be used as a promising carrier with uniform sustained release characteristics.

scholarly journals Annual variations of the 214Po, 213Po and 212Po half-life values

2020 ◽  
Vol 1690 ◽  
pp. 012029
Author(s):  
E N Alexeev ◽  
A M Gangapshev ◽  
Yu M Gavrilyuk ◽  
A M Gezhaev ◽  
V V Kazalov ◽  
...  
Keyword(s):  
Half Life ◽  
Annual Variations ◽  
Life Values

Half-lives of spherical proton emitters within the framework of fractional calculus

2014 ◽  
Vol 23 (09) ◽  
pp. 1450044 ◽  
Author(s):  
Abdullah Engin Çalik ◽  
Hüseyin Şirin ◽  
Hüseyin Ertik ◽  
Buket Öder ◽  
Mürsel Şen
Keyword(s):  
Fractional Calculus ◽  
Fractional Derivative ◽  
Nuclear Structure ◽  
Caputo Fractional Derivative ◽  
Half Life ◽  
Nuclear Decay ◽  
Life Values ◽  
Derivative Order

In this paper, the half-life values of spherical proton emitters such as Sb , Tm , Lu , Ta , Re , Ir , Au , Tl and Bi have been calculated within the framework of fractional calculus. Nuclear decay equation, related to this phenomenon, has been resolved by using Caputo fractional derivative. The order of fractional derivative μ being considered is 0 < μ ≤ 1, and characterizes the fractality of time. Half-life values have been calculated equivalent with empirical ones. The dependence of fractional derivative order μ on the nuclear structure has also been investigated.

Surfactant metabolism of newborn lamb lungs studied in vivo

1980 ◽  
Vol 49 (6) ◽  
pp. 1091-1098 ◽  
Author(s):  
A. Jobe ◽  
M. Ikegami ◽  
I. Sarton-Miller ◽  
L. Barajas
Keyword(s):  
Palmitic Acid ◽  
Intravenous Injection ◽  
Half Life ◽  
Lamellar Body ◽  
Lung Parenchyma ◽  
Newborn Lamb ◽  
Specific Activities ◽  
Life Values ◽  
Surfactant Metabolism

Surfactant, microsomal, and lamellar body fractions were isolated from the lungs of 5-day-old lambs 0.21-55 h after the intravenous injection of radiolabeled palmitic acid. The specific activities as cpm/mumol phospholipid phosphate of phosphatidylcholine, saturated phosphatidylcholine, phosphatidylglycerol, and phosphatidylethanolamine were measured. The palmitate-labeled phospholipids disappeared from the lung parenchyma with a half-life of approximately 50 h. The radiolabel disappeared from phosphatidylcholine, saturated phosphatidylcholine, phosphatidylglycerol, and phosphatidylethanolamine of microsomal fractions with initial half-life values of 4.5, 4.6, 1.9, and 23.9 h, respectively. The labeled phospholipids rapidly appeared in the lamellar body fraction and accumulated in the surfactant of the lambs in a linear fashion for 35 h. The curves for the labeling of surfactant with radiolabeled saturated phosphatidylcholine, phosphatidylglycerol, and phosphatidylethanolamine were similar to the curve for phosphatidylcholine.

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