scholarly journals Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling‐dependent manner

2020 ◽  
Vol 112 (14) ◽  
pp. 1043-1056
Author(s):  
Aileen S. W. Li ◽  
Yusuke Marikawa
Keyword(s):  
Retinoic Acid ◽  
Histone Deacetylase ◽  
Dependent Manner ◽  
Retinoic Acid Signaling ◽  
Axial Elongation ◽  
Methoxyacetic Acid

scholarly journals A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors

2007 ◽  
Vol 104 (45) ◽  
pp. 17777-17782 ◽  
Author(s):  
M. T. Epping ◽  
L. Wang ◽  
J. A. Plumb ◽  
M. Lieb ◽  
H. Gronemeyer ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Genetic Screen ◽  
Retinoic Acid Signaling

scholarly journals 8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1

2021 ◽  
Vol 22 (11) ◽  
pp. 5516
Author(s):  
Qiting Zhang ◽  
Ziyan Wang ◽  
Xinyuan Chen ◽  
Haoxiang Qiu ◽  
Yifan Gu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Dna Methyltransferase ◽  
Hdac Inhibitors ◽  
Mitochondrial Pathway ◽  
Epigenetic Therapy ◽  
Protein Interaction Data ◽  
Dependent Manner ◽  
Histone Deacetylase 1 ◽  
Histiocytic Lymphoma ◽  
Dose Dependent

Epigenetic therapy using histone deacetylase (HDAC) inhibitors has become an attractive project in new drug development. However, DNA methylation and histone acetylation are important epigenetic ways to regulate the occurrence and development of leukemia. Given previous studies, N-(2-aminophenyl)benzamide acridine (8a), as a histone deacetylase 1 (HDAC1) inhibitor, induces apoptosis and shows significant anti-proliferative activity against histiocytic lymphoma U937 cells. HDAC1 plays a role in the nucleus, which we confirmed by finding that 8a entered the nucleus. Subsequently, we verified that 8a mainly passes through the endogenous (mitochondrial) pathway to induce cell apoptosis. From the protein interaction data, we found that 8a also affected the expression of DNA methyltransferase 1 (DNMT1). Therefore, an experiment was performed to assess the binding of 8a to DNMT1 at the molecular and cellular levels. We found that the binding strength of 8a to DNMT1 enhanced in a dose-dependent manner. Additionally, 8a inhibits the expression of DNMT1 mRNA and its protein. These findings suggested that the anti-proliferative and pro-apoptotic activities of 8a against leukemia cells were achieved by targeting HDAC1 and DNMT1.

Effect of retinoic acid signaling on Ripply3 expression and pharyngeal arch morphogenesis in mouse embryos

2021 ◽  
Author(s):  
Tadashi Okubo ◽  
Keiko Hara ◽  
Sadahiro Azuma ◽  
Shinji Takada
Keyword(s):  
Retinoic Acid ◽  
Mouse Embryos ◽  
Pharyngeal Arch ◽  
Retinoic Acid Signaling

scholarly journals Median facial clefts in Xenopus laevis: Roles of retinoic acid signaling and homeobox genes

2012 ◽  
Vol 365 (1) ◽  
pp. 229-240 ◽  
Author(s):  
Allyson E. Kennedy ◽  
Amanda J.G. Dickinson
Keyword(s):  
Retinoic Acid ◽  
Xenopus Laevis ◽  
Homeobox Genes ◽  
Retinoic Acid Signaling ◽  
Facial Clefts

scholarly journals Cardiac Remodeling Induced by All-Trans Retinoic Acid is Detrimental in Normal Rats

2017 ◽  
Vol 43 (4) ◽  
pp. 1449-1459 ◽  
Author(s):  
Renata A. C. Silva ◽  
Andréa F. Gonçalves ◽  
Priscila P. dos Santos ◽  
Bruna Rafacho ◽  
Renan F. T. Claro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinoic Acid ◽  
Energy Metabolism ◽  
Cardiac Remodeling ◽  
Citrate Synthase ◽  
Isolated Heart ◽  
Lipid Hydroperoxide ◽  
Dependent Manner ◽  
Heart Study ◽  
Dose Dependent

Background/Aims: This study aimed to discern whether the cardiac alterations caused by retinoic acid (RA) in normal adult rats are physiologic or pathologic. Methods and Results: Wistar rats were assigned into four groups: control animals (C, n = 20) received a standard rat chow; animals fed a diet supplemented with 0.3 mg/kg/day all-trans-RA (AR1, n = 20); animals fed a diet supplemented with 5 mg/kg/day all-trans-RA (AR2, n = 20); and animals fed a diet supplemented with 10 mg/kg/day all-trans-RA (AR3, n = 20). After 2 months, the animals were submitted to echocardiogram, isolated heart study, histology, energy metabolism status, oxidative stress condition, and the signaling pathway involved in the cardiac remodeling induced by RA. RA increased myocyte cross-sectional area in a dose-dependent manner. The treatment did not change the morphological and functional variables, assessed by echocardiogram and isolated heart study. In contrast, RA changed catalases, superoxide dismutase, and glutathione peroxidases and was associated with increased values of lipid hydroperoxide, suggesting oxidative stress. RA also reduced citrate synthase, enzymatic mitochondrial complex II, ATP synthase, and enzymes of fatty acid metabolism and was associated with increased enzymes involved in glucose use. In addition, RA increased JNK 1/2 expression, without changes in TGF-β, PI3K, AKT, NFκB, S6K, and ERK. Conclusion: In normal rats, RA induces cardiac hypertrophy in a dose-dependent manner. The non-participation of the PI3K/Akt pathway, associated with the participation of the JNK pathway, oxidative stress, and changes in energy metabolism, suggests that cardiac remodeling induced by RA supplementation is deleterious.

scholarly journals GABAergic differentiation in the basal ganglia requires retinoic acid signaling

2011 ◽  
Vol 356 (1) ◽  
pp. 181
Author(s):  
Christina Chatzi ◽  
Thomas Brade ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Basal Ganglia ◽  
Retinoic Acid Signaling

scholarly journals Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner

2017 ◽  
Vol 135 (4) ◽  
pp. 148-155 ◽  
Author(s):  
Qingran Li ◽  
Chujie Ding ◽  
Tuo Meng ◽  
Wenjie Lu ◽  
Wenyue Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Erk Signaling ◽  
Dependent Manner ◽  
Colorectal Cancer Cells
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