Mobile phone use while driving is one of the major road safety risks. In surveys from different settings, the rate of mobile phone use while driving ranged from 1 to 11%. Literature from observational and experimental studies show that driving capacities such as reacting to traffic hazards, maintaining a central lane position, maintaining a safe distance and speed are negatively affected when using a mobile phone while driving. Several epidemiological studies suggest that motor vehicle collision risks increase by two to nine times when using a mobile phone (handheld or hands-free) compared to not using the phone while driving. Considering these findings, almost three-quarters of the countries have adopted legislation banning the use of handheld mobile phone devices while driving. These interventions, however, are insufficient to deal with the use of hands-free mobile phones while driving and texting which are challenging to ascertain and prevent. Currently, “in-vehicle” and collision avoidance technologies are being evaluated to further reduce the impact of these road menaces in our society.