Synthesis and fluorescent properties of europium (III) complexes based on novel coumarin derivatives

Luminescence ◽  
2022 ◽  
Author(s):  
Zuping Guo ◽  
Huang Wei ◽  
Shuaishuai Yang ◽  
Zhongqian Hu ◽  
Guizhi Li ◽  
...  
Keyword(s):  
Coumarin Derivatives ◽  
Fluorescent Properties

scholarly journals Synthesis and Study of the fluorescent properties of 4-hydroxy-coumarin derivatives

2021 ◽  
Vol 1795 (1) ◽  
pp. 012001
Author(s):  
Yasameen K. Al-Majedy ◽  
Hiba H. Ibraheem ◽  
Shemaa Shamel ◽  
Ahmed A. Al-Amiery
Keyword(s):  
Coumarin Derivatives ◽  
Fluorescent Properties ◽  
Hydroxy Coumarin

scholarly journals Synthesis and Fluorescent Properties of Coumarin Derivatives as Analytical Reagents

1980 ◽  
Vol 100 (3) ◽  
pp. 289-294 ◽  
Author(s):  
SHUJIRO GOYA ◽  
AKIRA TAKADATE ◽  
TOSHIAKI TANAKA ◽  
FUMIKO NAKASHIMA
Keyword(s):  
Coumarin Derivatives ◽  
Fluorescent Properties ◽  
Analytical Reagents

Coumarin derivatives from the roots of Heptaptera cilicica

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
Z Güvenalp ◽  
H Özbek ◽  
G Yılmaz ◽  
C Kazaz
Keyword(s):  
Coumarin Derivatives

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

OH- Removal and its Effect on the Fluorescent Properties of Er3+/Yb3+ Co-doped Barium Gallogermanate Glass

2009 ◽  
Vol 24 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Xiao-Ping JIANG ◽  
Zhong-Min YANG ◽  
Zhou-Ming FENG
Keyword(s):  
Fluorescent Properties ◽  
Co Doped

Fluorescenсе Properties of Complexes of Coumarin Derivatives/CdTe Quantum Dots under Interaction with Ammonia Molecules in Microconcentrations

2016 ◽  
Vol 8 (4(1)) ◽  
pp. 04032-1-04032-5
Author(s):  
V. P. Mitsai ◽  
◽  
A. G. Misyura ◽  
S. V. Kryvets ◽  
Ya. P. Lazorenko ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cdte Quantum Dots ◽  
Coumarin Derivatives

Recent Advances in the Synthesis of Coumarin Derivatives via Pechmann Condensation

2016 ◽  
Vol 20 (7) ◽  
pp. 798-828 ◽  
Author(s):  
Abhay S. Zambare ◽  
Firoz A. Kalam Khan ◽  
Sureshchandra P. Zambare ◽  
Shantanu D. Shinde ◽  
Jaiprakash N. Sangshetti
Keyword(s):  
Coumarin Derivatives ◽  
Pechmann Condensation ◽  
Recent Advances

Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition

2020 ◽  
Vol 20 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Carla S. Francisco ◽  
Clara L. Javarini ◽  
Iatahanderson de S. Barcelos ◽  
Pedro A.B. Morais ◽  
Heberth de Paula ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Glycogen Synthase ◽  
Synthetic Methods ◽  
Kinase Assay ◽  
Crystallographic Structure ◽  
Coumarin Derivatives ◽  
Enzymatic Production ◽  
Docking Simulations ◽  
In Silico Studies ◽  
Gsk 3Β

Background: Glycogen synthase kinase-3 (GSK-3) is involved in the phosphorylation and inactivation of glycogen synthase. GSK-3 inhibitors have been associated with a variety of diseases, including Alzheimer´s disease (AD), diabetes type II, neurologic disorders, and cancer. The inhibition of GSK-3β isoforms is likely to represent an effective strategy against AD. Objective: The present work aimed to design and synthesize coumarin derivatives to explore their potential as GSK-3β kinase inhibitors. Method: The through different synthetic methods were used to prepare coumarin derivatives. The GSK-3β activity was measured through the ADP-Glo™ Kinase Assay, which quantifies the kinasedependent enzymatic production of ADP from ATP, using a coupled-luminescence-based reaction. A docking study was performed by using the crystallographic structure of the staurosporine/GSK-3β complex [Protein Data Bank (PDB) code: 1Q3D]. Results: The eleven coumarin derivatives were obtained and evaluated as potential GSK-3β inhibitors. Additionally, in silico studies were performed. The results revealed that the compounds 5c, 5d, and 6b inhibited GSK-3β enzymatic activity by 38.97–49.62% at 1 mM. The other coumarin derivatives were tested at 1 mM, 1 µM, and 1 nM concentrations and were shown to be inhibitor candidates, with significant IC50 (1.224–6.875 µM) values, except for compound 7c (IC50 = 10.809 µM). Docking simulations showed polar interactions between compound 5b and Lys85 and Ser203, clarifying the mechanism of the most potent activity. Conclusion: The coumarin derivatives 3a and 5b, developed in this study, showed remarkable activity as GSK-3β inhibitors.

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