The Effects of Flux on the Clearance of Minute Virus of Mice during Constant Flux Virus Filtration

2021 ◽  
Author(s):  
Rong Fan ◽  
Namila ◽  
Davar Sansongko ◽  
S Ranil Wickramasinghe ◽  
Mi Jin ◽  
...  
Keyword(s):  
Minute Virus Of Mice ◽  
Constant Flux ◽  
Minute Virus ◽  
Virus Filtration

A precise map of splice junctions in the mRNAs of minute virus of mice, an autonomous parvovirus.

1986 ◽  
Vol 59 (3) ◽  
pp. 564-573 ◽  
Author(s):  
C V Jongeneel ◽  
R Sahli ◽  
G K McMaster ◽  
B Hirt
Keyword(s):  
Minute Virus Of Mice ◽  
Minute Virus ◽  
Splice Junctions

Characterization of the cell type-specific determinant in the genome of minute virus of mice.

1988 ◽  
Vol 62 (2) ◽  
pp. 552-557 ◽  
Author(s):  
J P Antonietti ◽  
R Sahli ◽  
P Beard ◽  
B Hirt
Keyword(s):  
Cell Type ◽  
Minute Virus Of Mice ◽  
Cell Type Specific ◽  
Minute Virus ◽  
Specific Determinant

Specific initiation of replication at the right-end telomere of the closed species of minute virus of mice replicative-form DNA.

1997 ◽  
Vol 71 (2) ◽  
pp. 971-980 ◽  
Author(s):  
A Q Baldauf ◽  
K Willwand ◽  
E Mumtsidu ◽  
J P Nüesch ◽  
J Rommelaere
Keyword(s):  
Replicative Form ◽  
Minute Virus Of Mice ◽  
Initiation Of Replication ◽  
Minute Virus ◽  
The Right

scholarly journals DNA Polymerase δ-Dependent Formation of a Hairpin Structure at the 5′ Terminal Palindrome of the Minute Virus of Mice Genome

Virology ◽  
1996 ◽  
Vol 216 (1) ◽  
pp. 258-264 ◽  
Author(s):  
NANDINI COSSONS ◽  
EMMANUEL A. FAUST ◽  
MARIA ZANNIS-HADJOPOULOS
Keyword(s):  
Dna Polymerase ◽  
Hairpin Structure ◽  
Minute Virus Of Mice ◽  
Dna Polymerase Δ ◽  
Minute Virus

Removal of minute virus of mice-mock virus particles by nanofiltration of culture growth media supplemented with 10% human platelet lysate

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S176
Author(s):  
L. Barro ◽  
L. Delila ◽  
O. Nebie ◽  
Y. Wu ◽  
F. Knutson ◽  
...  
Keyword(s):  
Human Platelet ◽  
Platelet Lysate ◽  
Growth Media ◽  
Minute Virus Of Mice ◽  
Virus Particles ◽  
Human Platelet Lysate ◽  
Minute Virus ◽  
Culture Growth

Parvovirus infection in children and pregnant women

2021 ◽  
Vol 19 (2) ◽  
pp. 119-125
Author(s):  
E.V. Mikhailova ◽  
◽  
T.K. Chudakova ◽  
D.Yu. Levin ◽  
A.V. Romanovskaya ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Ex Vivo ◽  
Parvovirus B19 ◽  
Virus Transmission ◽  
Intrauterine Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Minute Virus Of Mice ◽  
Gestation Age ◽  
B19 Parvovirus ◽  
Minute Virus

Parvovirus (PV) is a widespread infection, despite the fact that this pathogen was discovered only recently. The therapeutic effect of PV, in particular its oncolytic activity, is being actively studied now. Notably, PVs causing infections in animals, such as rat PV H-1, caninae PV, and rodent protoparvovirus (minute virus of mice) suppress oncogenesis in these animals. There is an ex vivo evidence of rat glioblastoma and gliosarcoma sensitivity to PV. The affinity of PV B19 to P-antigen located primarily on the membranes of erythroid cells is crucial for the disease pathogenesis. The teratogenic effect of PV B19 is associated with its ability to infect placental cells (P-antigen is present on the cells of chorionic villi and surface of the trophoblast). PV infection can be acquired or congenital, typical or atypical. The outcome of intrauterine infection with PV B19 largely depends on the gestation age when the infection occurred. Women infected during the second trimester are at higher risk of vertical transmission and severe intrauterine pathology with a poor outcome than those infected during the third trimester. Constant contact with young children significantly increases the risk of PV B19 infection among pregnant women with no immunity to this virus. Serum is the most convenient biomaterial for detecting both PV DNA and virus-specific antibodies. One test for anti-PV IgG using enzyme-linked immunosorbent assay is sufficient to determine the immune status of a patient. Polymerase chain reaction with amniotic fluid is used to diagnose intrauterine infection with PV B19. Blood components and products should be checked for PV B19. High frequency of PV B19 detection in the blood of donors necessitates the development of special measures aimed at prevention of virus transmission. Key words: pregnant women, children, parvovirus B19, parvovirus infection

scholarly journals The Effect of Regulatory Sequence Elements upon the Initiation of DNA Replication of the Minute Virus of Mice

Virology ◽  
1996 ◽  
Vol 224 (1) ◽  
pp. 320-325 ◽  
Author(s):  
Nandini Cossons ◽  
Maria Zannis-Hadjopoulos ◽  
Patrick Tam ◽  
Caroline R. Astell ◽  
Emmanuel A. Faust
Keyword(s):  
Dna Replication ◽  
Regulatory Sequence ◽  
Minute Virus Of Mice ◽  
Sequence Elements ◽  
Minute Virus ◽  
Initiation Of Dna Replication

scholarly journals Hypoxic-response elements in the oncolytic parvovirus Minute virus of mice do not allow for increased vector production at low oxygen concentration

2006 ◽  
Vol 87 (5) ◽  
pp. 1197-1201 ◽  
Author(s):  
Charlotte Servais ◽  
Perrine Caillet-Fauquet ◽  
Marie-Louise Draps ◽  
Thierry Velu ◽  
Yvan de Launoit ◽  
...  
Keyword(s):  
Cell Metabolism ◽  
Consensus Sequence ◽  
High Titre ◽  
Host Cells ◽  
Low Oxygen ◽  
Minute Virus Of Mice ◽  
Minute Virus ◽  
Responsive Element ◽  
Low Oxygen Concentration

Vectors derived from the autonomous parvovirus Minute virus of mice, MVM(p), are promising tools for the gene therapy of cancer. The validation of their in vivo anti-tumour effect is, however, hampered by the difficulty to produce high-titre stocks. In an attempt to increase vector titres, host cells were subjected to low oxygen tension (hypoxia). It has been shown that a number of viruses are produced at higher titres under these conditions. This is the case, among others, for another member of the family Parvoviridae, the erythrovirus B19 virus. Hypoxia stabilizes a hypoxia-inducible transcription factor (HIF-1α) that interacts with a ‘hypoxia-responsive element’ (HRE), the consensus sequence of which (A/GCGTG) is present in the B19 and MVM promoters. Whilst the native P4 promoter was induced weakly in hypoxia, vector production was reduced dramatically, and adding HRE elements to the P4 promoter of the vector did not alleviate this reduction. Hypoxia has many effects on cell metabolism. Therefore, even if the P4 promoter is activated, the cellular factors that are required for the completion of the parvoviral life cycle may not be expressed.

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