scholarly journals Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model

2015 ◽  
Vol 102 (7) ◽  
pp. 813-825 ◽  
Author(s):  
H. Kuroki ◽  
H. Hayashi ◽  
S. Nakagawa ◽  
K. Sakamoto ◽  
T. Higashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Regeneration ◽  
Experimental Model ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Thrombospondin 1 ◽  
Signal Activation

scholarly journals Expression of the Type-1 Repeats of Thrombospondin-1 Inhibits Tumor Growth Through Activation of Transforming Growth Factor-β

2004 ◽  
Vol 165 (2) ◽  
pp. 541-552 ◽  
Author(s):  
Karen O. Yee ◽  
Michael Streit ◽  
Thomas Hawighorst ◽  
Michael Detmar ◽  
Jack Lawler
Keyword(s):  
Growth Factor ◽  
Tumor Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Thrombospondin 1

Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor β-1

2003 ◽  
Vol 31 (2) ◽  
pp. 99-109 ◽  
Author(s):  
Kensuke Sakai ◽  
Yukio Sumi ◽  
Hisako Muramatsu ◽  
Ken-ichiro Hata ◽  
Takashi Muramatsu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Collagen Gel ◽  
Transforming Growth Factor Β ◽  
Collagen Gel Contraction ◽  
Thrombospondin 1

scholarly journals BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1

2020 ◽  
Vol 13 (639) ◽  
pp. eaba3880 ◽  
Author(s):  
Cyril Anastasi ◽  
Patricia Rousselle ◽  
Maya Talantikite ◽  
Agnès Tessier ◽  
Caroline Cluzel ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Substantial Effect ◽  
Matricellular Protein ◽  
Matrix Assembly ◽  
Morphogenetic Protein ◽  
Thrombospondin 1

Bone morphogenetic protein 1 (BMP-1) is an important metalloproteinase that synchronizes growth factor activation with extracellular matrix assembly during morphogenesis and tissue repair. The mechanisms by which BMP-1 exerts these effects are highly context dependent. Because BMP-1 overexpression induces marked phenotypic changes in two human cell lines (HT1080 and 293-EBNA cells), we investigated how BMP-1 simultaneously affects cell-matrix interactions and growth factor activity in these cells. Increasing BMP-1 led to a loss of cell adhesion that depended on the matricellular glycoprotein thrombospondin-1 (TSP-1). BMP-1 cleaved TSP-1 between the VWFC/procollagen-like domain and the type 1 repeats that mediate several key TSP-1 functions. This cleavage induced the release of TSP-1 C-terminal domains from the extracellular matrix and abolished its previously described multisite cooperative interactions with heparan sulfate proteoglycans and CD36 on HT1080 cells. In addition, BMP-1–dependent proteolysis potentiated the TSP-1–mediated activation of latent transforming growth factor–β (TGF-β), leading to increased signaling through the canonical SMAD pathway. In primary human corneal stromal cells (keratocytes), endogenous BMP-1 cleaved TSP-1, and the addition of exogenous BMP-1 enhanced cleavage, but this had no substantial effect on cell adhesion. Instead, processed TSP-1 promoted the differentiation of keratocytes into myofibroblasts and stimulated production of the myofibroblast marker α-SMA, consistent with the presence of processed TSP-1 in human corneal scars. Our results indicate that BMP-1 can both trigger the disruption of cell adhesion and stimulate TGF-β signaling in TSP-1–rich microenvironments, which has important potential consequences for wound healing and tumor progression.

ANDROGEN-SENSITIVE THROMBOSPONDIN-1 REGULATES PROSTATE EPITHELIAL PROLIFERATION AND TRANSFORMING GROWTH FACTOR-β ACTIVATION IN THE MOUSE PROSTATE

2009 ◽  
Vol 181 (4S) ◽  
pp. 93-94
Author(s):  
Jennifer A. Doll ◽  
Chung Lee ◽  
Anders Bergh ◽  
Philip Fitchev ◽  
Mona Cornwell ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Epithelial Proliferation ◽  
Mouse Prostate ◽  
Thrombospondin 1

The role of thrombospondin-1 and transforming growth factor-β after spinal cord injury in the rat

2009 ◽  
Vol 16 (6) ◽  
pp. 818-821 ◽  
Author(s):  
Xianghua Wang ◽  
Weiping Chen ◽  
Wangmi Liu ◽  
Jiayan Wu ◽  
Yanqi Shao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cord Injury ◽  
Thrombospondin 1

scholarly journals A Thrombospondin-1 Antagonist of Transforming Growth Factor-β Activation Blocks Cardiomyopathy in Rats with Diabetes and Elevated Angiotensin II

2007 ◽  
Vol 171 (3) ◽  
pp. 777-789 ◽  
Author(s):  
Souad Belmadani ◽  
Juan Bernal ◽  
Chih-Chang Wei ◽  
Manuel A. Pallero ◽  
Louis Dell'Italia ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Thrombospondin 1

scholarly journals Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice

Hepatology ◽  
2004 ◽  
Vol 40 (5) ◽  
pp. 1098-1105 ◽  
Author(s):  
Shoshiro Oe ◽  
Eric R. Lemmer ◽  
Elizabeth A. Conner ◽  
Valentina M. Factor ◽  
Per Levéen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Regeneration ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β
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