scholarly journals Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

2022 ◽  
Author(s):  
Dan Wu ◽  
Yi Yang ◽  
Yiran Hou ◽  
Zifeng Zhao ◽  
Ning Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Mitochondrial Fission ◽  
Carcinoma Cells ◽  
Sirtuin 1 ◽  
Hepatocellular Carcinoma Cells

scholarly journals Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Johanna Matilainen ◽  
Anne-Mari Mustonen ◽  
Kirsi Rilla ◽  
Reijo Käkelä ◽  
Sanna P. Sihvo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Orotic Acid ◽  
Acid Metabolism ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

2015 ◽  
Vol 63 (6) ◽  
pp. 1378-1389 ◽  
Author(s):  
Jibin Li ◽  
Qichao Huang ◽  
Xiaoyu Long ◽  
Jing Zhang ◽  
Xiaojun Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yotsawat Pomyen ◽  
Anuradha Budhu ◽  
Jittiporn Chaisaingmongkol ◽  
Marshonna Forgues ◽  
Hien Dang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Treatment Effectiveness ◽  
Data Types ◽  
Serum Metabolites ◽  
Non Invasive ◽  
Metabolic Genes ◽  
Tissue Metabolites

AbstractTreatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies. However, the lack of robust biomarkers, particularly a non-invasive diagnostic tool, precludes significant improvement of clinical outcomes for HCC patients. Serum metabolites are one of the best non-invasive means for determining patient prognosis, as they are stable end-products of biochemical processes in human body. In this study, we aimed to identify prognostic serum metabolites in HCC. To determine serum metabolites that were relevant and representative of the tissue status, we performed a two-step correlation analysis to first determine associations between metabolic genes and tissue metabolites, and second, between tissue metabolites and serum metabolites among 49 HCC patients, which were then validated in 408 additional Asian HCC patients with mixed etiologies. We found that certain metabolic genes, tissue metabolites and serum metabolites can independently stratify HCC patients into prognostic subgroups, which are consistent across these different data types and our previous findings. The metabolic subtypes are associated with β-oxidation process in fatty acid metabolism, where patients with worse survival outcome have dysregulated fatty acid metabolism. These serum metabolites may be used as non-invasive biomarkers to define prognostic tumor molecular subtypes for HCC.

Effects of iodinated fatty acid ester on human hepatocellular carcinoma cells

1991 ◽  
Vol 32 (1) ◽  
pp. 16 ◽  
Author(s):  
Hoguen Kim ◽  
Chanil Park ◽  
Yoo Bock Lee ◽  
Hyung Sik Yoo ◽  
Jeon Han Park ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Ester ◽  
Acid Ester ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Human Hepatocellular Carcinoma Cells

ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway

2020 ◽  
Author(s):  
Junru Chen ◽  
Chaofeng Ding ◽  
Yunhao Chen ◽  
Wendi Hu ◽  
Chengkuan Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Prognostic value of fatty acid metabolism-related genes in patients with hepatocellular carcinoma

Aging ◽  
2021 ◽  
Author(s):  
Dongsheng He ◽  
Lifang Cai ◽  
Weiming Huang ◽  
Qingqing Weng ◽  
Xi Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Prognostic Value ◽  
Acid Metabolism

scholarly journals The transcriptome of early GGT/KRT19-positive hepatocellular carcinoma reveals a downregulated gene expression profile associated with fatty acid metabolism

Genomics ◽  
2021 ◽  
Author(s):  
María Paulette Castro-Gil ◽  
Julia Esperanza Torres-Mena ◽  
Rosa M. Salgado ◽  
Said A. Muñoz-Montero ◽  
José Michael Martínez-Garcés ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Downregulated Gene

scholarly journals Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPARα/γ-AMPK-SIRT1 Pathway and Fatty Acid Metabolism

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Yufei Bei ◽  
Boyu Tia ◽  
Yuze Li ◽  
Yingzhu Guo ◽  
Shufei Deng ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Influenza A Virus ◽  
Fatty Acid Metabolism ◽  
Influenza A ◽  
Acid Metabolism ◽  
Fatty Acid Biosynthesis ◽  
Sirtuin 1 ◽  
Peroxisome Proliferator ◽  
In Vivo Test

The peroxisome proliferator-activated receptor (PPAR) α/γ-adenosine 5 ′ -monophosphate- (AMP-) activated protein kinase- (AMPK-) sirtuin-1 (SIRT1) pathway and fatty acid metabolism are reported to be involved in influenza A virus (IAV) replication and IAV-pneumonia. Through a cell-based peroxisome proliferator responsive element- (PPRE-) driven luciferase bioassay, we have investigated 145 examples of traditional Chinese medicines (TCMs). Several TCMs, such as Polygonum cuspidatum, Rheum officinale Baillon, and Aloe vera var. Chinensis (Haw.) Berg., were found to possess high activity. We have further detected the anti-IAV activities of emodin (EMO) and its analogs, a group of common important compounds of these TCMs. The results showed that emodin and its several analogs possess excellent anti-IAV activities. The pharmacological tests showed that emodin significantly activated PPARα/γ and AMPK, decreased fatty acid biosynthesis, and increased intracellular ATP levels. Pharmaceutical inhibitors, siRNAs for PPARα/γ and AMPKα1, and exogenous palmitate impaired the inhibition of emodin. The in vivo test also showed that emodin significantly protected mice from IAV infection and pneumonia. Pharmacological inhibitors for PPARα/γ and AMPK signal and exogenous palmitate could partially counteract the effects of emodin in vivo. In conclusion, emodin and its analogs are a group of promising anti-IAV drug precursors, and the pharmacological mechanism of emodin is linked to its ability to regulate the PPARα/γ-AMPK pathway and fatty acid metabolism.

Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: Review and hypothesis

Hepatology ◽  
1993 ◽  
Vol 18 (3) ◽  
pp. 669-676 ◽  
Author(s):  
Robert K. Ockner ◽  
Raja M. Kaikaus ◽  
Nathan M. Bass
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84931 ◽  
Author(s):  
Bin Zhang ◽  
Juan Chen ◽  
Alfred S. L. Cheng ◽  
Ben C. B. Ko
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epigenetic Modifications ◽  
Carcinoma Cells ◽  
Sirtuin 1 ◽  
Hepatocellular Carcinoma Cells ◽  
Tert Gene
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