scholarly journals Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yotsawat Pomyen ◽  
Anuradha Budhu ◽  
Jittiporn Chaisaingmongkol ◽  
Marshonna Forgues ◽  
Hien Dang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Treatment Effectiveness ◽  
Data Types ◽  
Serum Metabolites ◽  
Non Invasive ◽  
Metabolic Genes ◽  
Tissue Metabolites

AbstractTreatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies. However, the lack of robust biomarkers, particularly a non-invasive diagnostic tool, precludes significant improvement of clinical outcomes for HCC patients. Serum metabolites are one of the best non-invasive means for determining patient prognosis, as they are stable end-products of biochemical processes in human body. In this study, we aimed to identify prognostic serum metabolites in HCC. To determine serum metabolites that were relevant and representative of the tissue status, we performed a two-step correlation analysis to first determine associations between metabolic genes and tissue metabolites, and second, between tissue metabolites and serum metabolites among 49 HCC patients, which were then validated in 408 additional Asian HCC patients with mixed etiologies. We found that certain metabolic genes, tissue metabolites and serum metabolites can independently stratify HCC patients into prognostic subgroups, which are consistent across these different data types and our previous findings. The metabolic subtypes are associated with β-oxidation process in fatty acid metabolism, where patients with worse survival outcome have dysregulated fatty acid metabolism. These serum metabolites may be used as non-invasive biomarkers to define prognostic tumor molecular subtypes for HCC.

ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway

2020 ◽  
Author(s):  
Junru Chen ◽  
Chaofeng Ding ◽  
Yunhao Chen ◽  
Wendi Hu ◽  
Chengkuan Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Prognostic value of fatty acid metabolism-related genes in patients with hepatocellular carcinoma

Aging ◽  
2021 ◽  
Author(s):  
Dongsheng He ◽  
Lifang Cai ◽  
Weiming Huang ◽  
Qingqing Weng ◽  
Xi Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Prognostic Value ◽  
Acid Metabolism

scholarly journals The transcriptome of early GGT/KRT19-positive hepatocellular carcinoma reveals a downregulated gene expression profile associated with fatty acid metabolism

Genomics ◽  
2021 ◽  
Author(s):  
María Paulette Castro-Gil ◽  
Julia Esperanza Torres-Mena ◽  
Rosa M. Salgado ◽  
Said A. Muñoz-Montero ◽  
José Michael Martínez-Garcés ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Downregulated Gene

Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: Review and hypothesis

Hepatology ◽  
1993 ◽  
Vol 18 (3) ◽  
pp. 669-676 ◽  
Author(s):  
Robert K. Ockner ◽  
Raja M. Kaikaus ◽  
Nathan M. Bass
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Dysregulated fatty acid metabolism in hepatocellular carcinoma

2016 ◽  
Vol 3 (4) ◽  
pp. 241-251 ◽  
Author(s):  
Mingda Wang ◽  
Jun Han ◽  
Hao Xing ◽  
Han Zhang ◽  
Zhenli Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ning Wang ◽  
Hor-Yue Tan ◽  
Yuanjun Lu ◽  
Yau-Tuen Chan ◽  
Di Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Tumor Microenvironment ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Immune Cell ◽  
Cell Metabolism ◽  
Cancer Cell Metabolism ◽  
Immune Cell Response ◽  
Hcc Cells

AbstractAltered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that facilitates tumor progression. Herein, we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1 (PIWIL1) in mediating the crosstalk of fatty acid metabolism and immune response of human hepatocellular carcinoma (HCC). PIWIL1 expression in HCC was increased compared to normal hepatic tissues and was positively correlated with the proliferation rate of HCC cell lines. PIWIL1 overexpression accelerated in vitro proliferation and in vivo growth of HCC tumors, while PIWIL1 knockdown showed opposite effects. PIWIL1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic glycolysis. Inhibition of fatty acid metabolism abolished PIWIL1-induced HCC proliferation and growth. RNA-seq analysis revealed that immune system regulation might be involved, which was echoed by the experimental observation that PIWIL1-overexpressing HCC cells attracted myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment. MDSCs depletion reduced the proliferation and growth of PIWIL1-overexpressing HCC tumors. Complement C3, whose secretion was induced by PIWIL1 in HCC cells, mediates the interaction of HCC cells with MDSCs by activated p38 MAPK signaling in MDSCs, which in turn initiated expression of immunosuppressive cytokine IL10. Neutralizing IL10 secretion reduced the immunosuppressive activity of MDSCs in the microenvironment of PIWIL1-overexpressing HCC. Taken together, our study unraveled the critical role of PIWIL1 in initiating the interaction of cancer cell metabolism and immune cell response in HCC. Tumor cells-expressed PIWIL1 may be a potential target for the development of novel HCC treatment.

scholarly journals Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Johanna Matilainen ◽  
Anne-Mari Mustonen ◽  
Kirsi Rilla ◽  
Reijo Käkelä ◽  
Sanna P. Sihvo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Orotic Acid ◽  
Acid Metabolism ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals Multiomics-based analyses of KPNA2 highlight its multiple potentials in hepatocellular carcinoma

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12197
Author(s):  
Jinzhong Zhang ◽  
Xiuzhi Zhang ◽  
Lingxiao Wang ◽  
Chunyan Kang ◽  
Ningning Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Fatty Acid Synthase ◽  
Acid Metabolism ◽  
Methylation Status ◽  
Disease Free Survival ◽  
Gene Copy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Molecular Characteristics

Dysregulation and prognostic roles of Karyopherin α2 (KPNA2) were reported in many malignancies including hepatocellular carcinoma (HCC). A multi-omics analysis of KPNA2 is needed to gain a deeper understanding of its multilevel molecular characteristics and provide novel clues for HCC diagnosis, prognosis, and target therapy. Herein multi-omic alterations of KPNA2 were analyzed at genetic, epigenetic, transcript, and protein levels with evaluation of their relevance with clinicopathological features of HCC by integrative analyses. The significant correlations of KPNA2 expression with its gene copy number variation (CNV) and methylation status were shown through Spearman correlation analyses. With Cox regression, Kaplan-Meier survival, and receiver operating characteristic (ROC) analyses, based on the factors of KPNA2 CNV, methylation, expression, and tumor stage, risk models for HCC overall survival (OS) and disease-free survival (DFS) were constructed which could discriminate the 1-year, 3-year, and 5-year OS/DFS status effectively. With Microenvironment Cell Populations-counter (MCP-counter), the immune infiltrations of HCC samples were evaluated and their associations with KPNA2 were shown. KPNA2 expression in liver was found to be influenced by low fat diet and presented significant correlations with fatty acid metabolism and fatty acid synthase activity in HCC. KPNA2 was detected lowered in HCC patient’s plasma by enzyme linked immunosorbent assay (ELISA), consistent with its translocation to nuclei of HCC cells. In conclusion, KPNA2 multilevel dysregulation in HCC and its correlations with immune infiltration and the fatty acid metabolism pathway indicated its multiple roles in HCC. The clinicopathological significance of KPNA2 was highlighted through the in-depth analyses at multilevels.

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

2015 ◽  
Vol 63 (6) ◽  
pp. 1378-1389 ◽  
Author(s):  
Jibin Li ◽  
Qichao Huang ◽  
Xiaoyu Long ◽  
Jing Zhang ◽  
Xiaojun Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells
Sign in / Sign up

Export Citation Format

Share Document