A Body Shape Index (ABSI), hip index, and risk of cancer in the UK Biobank cohort

AbstractGenetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to cancer development and progression. Genetic associations were fewer in men compared to women. Prominent region-specific associations showed variants in loci VEGFA and HMGA1 for ABSI and KLF14 for HI in women, and C5orf67 and HOXC4/5 for ABSI and RSPO3, VEGFA and SLC30A10 for HI in men. Although more variants were associated with waist and hip circumference adjusted for BMI compared to ABSI and HI, associations with height had previously been reported for many of the additional variants, illustrating the importance of adjusting correctly for height.

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Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures

Cancer Causes & Control ◽

10.1007/s10552-014-0501-4 ◽

2014 ◽

Vol 26 (2) ◽

pp. 219-229 ◽

Cited By ~ 25

Author(s):

Geoffrey C. Kabat ◽

Xiaonan Xue ◽

Victor Kamensky ◽

Dorothy Lane ◽

Jennifer W. Bea ◽

...

Keyword(s):

Postmenopausal Women ◽

Body Shape ◽

Shape Index ◽

Anthropometric Measures ◽

A Body Shape Index

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Relationship between “a body shape index (ABSI)” and body composition in obese patients with type 2 diabetes

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-018-0323-8 ◽

2018 ◽

Vol 10 (1) ◽

Cited By ~ 12

Author(s):

Fernando Gomez-Peralta ◽

Cristina Abreu ◽

Margarita Cruz-Bravo ◽

Elvira Alcarria ◽

Gala Gutierrez-Buey ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Composition ◽

Body Shape ◽

Shape Index ◽

Obese Patients ◽

A Body Shape Index

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Effectiveness of Body Roundness Index (BRI) and a Body Shape Index (ABSI) in Predicting Hypertension: A Systematic Review and Meta-Analysis of Observational Studies

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182111607 ◽

2021 ◽

Vol 18 (21) ◽

pp. 11607

Author(s):

Julián F. Calderón-García ◽

Raúl Roncero-Martín ◽

Sergio Rico-Martín ◽

Jorge M. De Nicolás-Jiménez ◽

Fidel López-Espuela ◽

...

Keyword(s):

Body Shape ◽

Meta Analysis ◽

Characteristic Curve ◽

Shape Index ◽

Diagnostic Odds Ratio ◽

The Body ◽

Adult Women ◽

Summary Receiver Operating Characteristic ◽

The Difference ◽

A Body Shape Index

Introduction: The body roundness index (BRI) and a body shape index (ABSI) are novel anthropometric indices established to determine both the amount visceral adipose tissue and body fat. Objective: to investigate whether BRI and ABSI are better predictors of hypertension than body mass index (BMI), waist circumference (WC) or waist-to-height ratio (WHtR). Methods: A systematic search was conducted in the Scopus, PubMed and Web of Science databases up until 31 December 2020. Results: The estimated pooled area under curve [AUC (95% CI)] for BRI [0.67 (0.65–0.70)] for the prediction of hypertension were superior to that of ABSI (0.58 (0.56–0.60)), similar to that of BMI [0.67 (0.64–0.69)], and lower than those WC [0.68 (0.66–0.70)] and WHtR [0.68 (0.66–0.71)]. Nevertheless, the difference of BRI compared to WC and WHtR in the context of predicting hypertension was non-significant. ABSI was significantly lower (p < 0.05) than BRI, BMI, WC and WHtR. Similar findings were observed with the summary receiver operating characteristic curve (AUC-SROC). There were no significant differences between subgroups according to type of population or diagnostic criteria of hypertension. The diagnostic odds ratio (dORs) proved that increased BRI and ABSI were related with an elevated hypertension risk. Conclusions: BRI and ABSI have discriminatory power for hypertension in adult women and men from different populations. Although, WHtR and WC provided the best performance when assessing hypertension, no significant differences were found for BRI. Finally, BRI was significantly better predictor of hypertension than ABSI.

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