Association of lipid profile parameters, atherogenic index of plasma, anthropometric parameters with the severity of the COVID-19 course in Novosibirsk women

Background: Our study aimed to assess the relationship between the parameters of the lipid profile, atherogenic index of plasma (AIP), anthropometry influence with the severity of the new coronavirus infection COVID-19 in women. Material and methods. The study design was a cross-sectional study. The research included 138 women aged 29–82 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 61), moderate (n = 70) and severe (n = 7). Body mass index, waistline and hip circumference, waistline circumference to hip circumference index, total cholesterol, triglycerides, HDL, LDL, AIP were calculated. Statistical processing of the obtained results was carried out using the SPSS software package (version 20.0) using the Mann-Whitney test, univariate logistic regression analysis, Pearson chi-squared test. Results. The levels of HDL-cholesterol were significantly lower in group 3 compared with the level of HDL-cholesterol in women in group 2 (p2-3 = 0.046). BMI was higher in the moderately severe group compared to the mild one (26.32 [23.305; 30.4] versus 28.78 [24.72; 34.77], p1-2 = 0.026). Hip circumference was higher in patients with severe COVID-19 than in patients with mild course (104 [98; 112] versus 114 [109.5; 126], p1-3 = 0.039), AIP was higher in women with severe course compared to women with moderate and mild course (p1-3 = 0.043, p2-3 = 0.04). The results of the logistic regression analysis showed that the moderate course of COVID-19 is associated with BMI (OR = 1.09, 95 % CI 1.019–1.166, p1-2 = 0.012), and the severe course with WC (OR = 1.041, 95 % CI 1.001–1.084, p1-3 = 0.046), AIP value ≥ 0.11 (OR = 13.824, 95 % CI 1.505–126.964, p1-3 = 0.02; OR = 11,579, 95 % CI 1,266–105,219, p2-3 = 0.03) and HDL level < 40 mg/dl (OR = 14,750, 95 % CI 2,317–93,906, p1-3 = 0.004; OR = 8,000, 95 % CI 1,313– 48,538, p1-3 = 0.024). Conclusion. Patients from the group with moderate and severe course of the new coronavirus infection have higher body mass index, hip circumference, AIP, lower HDL values. The chance of a moderate course of COVID-19 is associated with an increased BMI value, and a severe course with WC, AIP ≥ 0.11 and HDL level < 40 mg/dl.

ANTHROPOMETRIC PROFILE OF PATIENTS LIVING WITH HIV/AIDS IN LVIV REGION

The body of PLHIV undergoes profound anthropometric changes in adipose tissue distribution, which develop under the influence of pathogenetic mechanisms caused by HIV and due to impaired side effects of ART. ART leads to the development of lipoatrophy / lipohypertrophy syndrome. This phenomenon is described as a syndrome characterized by the loss and/or accumulation of fat and has three types: lipohypertrophy, lipoatrophy, and mixed lipodystrophy. These changes in body shape are very important to determine because they are associated with negative disease dynamics and high mortality. Therefore, it is extremely important to detect this syndrome early to ensure a better quality of life for this population, as the clinical approach is not easy. Potential approaches to treatment, including lifestyle changes, with adequate eating habits, exercise, and some medical interventions, showed little effect in PLHIV. In this case can be effectively reduced through exercise. Despite the existence of established exercise guidelines, the effective dosage of exercise to reduce HRT requires verification. The aim. Study the anthropometric parameters in PLHIV and establish the relationship between the parameters and the degree of viral load (HV) of HIV, the level of CD4 + T-lymphocytes. Materials and methods: 60 patients aged 18 to 60 years were examined. We used standard methods of measuring the following anthropometric indicators: body weight, height, chest circumference, waist and hips. The waist-to-thigh ratio index was also determined. The calculation of the body mass index was performed according to the standard formula by dividing body weight (in kilograms) by the square of height (in square meters). The indicator 18.5-24.9 is considered normal. The level of CD4 + T-lymphocytes was determined by flow cytofluorometry. The viral load of HIV was determined by real-time PCR. Statistical indicators, median, Pearson's coefficient, Student's t-test, were calculated using Microsoft Excel 2016. Results. The average waist circumference was smaller in both the men of the experimental group (74.5 ± 10.3 cm) and the women of the experimental group (61.9 ± 11.0 cm) than in the control groups of men (90.4 ± 9.4 cm) and women (67.5 ± 7.3 cm (p <0.05)). The average ratio of waist circumference to hip circumference in the group of male PLHIV was 0.94 ± 0.08 cm in the control group of men - 0.97 ± 0.8 cm (p <0.05). In the group of female PLHIV, this indicator reached 0.86 ± 0.1 cm, and in the control group - 0.75 ± 0.3 cm (p <0.05). The mean forearm circumference was lower in the two research groups. However, in men with HIV (18.5 ± 3.1 cm) this figure was lower than in women with HIV (19.9 ± 3.9 cm (p <0.05)). Also, the circumference of the tibia was larger in female PLHIV (26.9 ± 3.9 cm) than in male PLHIV (20.8 ± 3.8 cm (p <0.05)). Conclusions. PLHIV at the stage of AIDS leads to the recomposition of the body. It is manifested by a decrease in BMI, waist circumference, hip, mid-upper arm, and calf, which indicates lipodystrophy. Increase in the index of the waist circumference to hip circumference ratio indicates a probable redistribution of adipose tissue. BMI cannot be used as an accurate method to determine obesity or lipodystrophy. A positive correlation was found between the value of the anthropometric profile and the level of viral load and CD4 + T-lymphocytes. Early administration of ART and dosed exercise is likely to have a positive effect on the body structure of PLHIV in the AIDS stage, although this requires further research.

Causal Associations of Obesity With the Intervertebral Degeneration, Low Back Pain, and Sciatica: A Two-Sample Mendelian Randomization Study

The role of obesity in the development of dorsopathies is still unclear. In this study, we assessed the associations between body mass index (BMI) and several dorsopathies including intervertebral disc degeneration (IVDD), low back pain (LBP), and sciatica by using the Mendelian randomization method. We also assessed the effect of several obesity-related traits on the same outcomes. Single-nucleotide polymorphisms associated with the exposures are extracted from summary-level datasets of previously published genome-wide association studies. Summary-level results of IVDD, LBP, and sciatica were from FinnGen. In our univariable Mendelian randomization analysis, BMI is significantly associated with increased risks of all dorsopathies including sciatica (OR = 1.33, 95% CI, 1.21–1.47, p = 5.19 × 10-9), LBP (OR = 1.28, 95% CI, 1.18–1.39, p = 6.60 × 10-9), and IVDD (OR = 1.23, 95% CI, 1.14–1.32, p = 2.48 × 10-8). Waist circumference, hip circumference, whole-body fat mass, fat-free mass, and fat percentage, but not waist–hip ratio, were causally associated with increased risks of IVDD and sciatica. Higher hip circumference, whole-body fat mass, fat-free mass, and fat percentage increased the risk of LBP. However, only whole-body fat-free mass remained to have a significant association with the risk of IVDD after adjusting for BMI with an odds ratio of 1.57 (95% CI, 1.32–1.86, p = 2.47 × 10-7). Proportions of BMI’s effect on IVDD, sciatica, and LBP mediated by leisure sedentary behavior were 41.4% (95% CI, 21.8%, 64.8%), 33.8% (95% CI, 17.5%, 53.4%), and 49.7% (95% CI, 29.4%, 73.5%), respectively. This study provides evidence that high BMI has causal associations with risks of various dorsopathies. Weight control is a good measure to prevent the development of dorsopathies, especially in the obese population.

Hubungan Status Obesitas Sentral dengan Pengalaman Karies (Indeks DMFT) pada Individu Dewasa Muda

Karies dan obesitas merupakan permasalahan yang sering dihadapi pada bidang kesehatan masyarakat terutama pada individu dewasa muda dan prevalensi kondisi tersebut terus meningkat di seluruh dunia. Status obesitas sentral telah dilaporkan memiliki korelasi dengan pengalaman karies, hal tersebut belum bayak dipelajari di Indonesia. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara pengalaman karies dan status obesitas sentral pada mahasiswa dengan kondisi sehat usia 18-22 tahun. Penelitian cross-sectional ini dilakukan di Institut Ilmu Kesehatan Bhakti Wiyata Kediri dengan jumlah sampel 120. Pengalaman karies dinilai dengan indeks decayed missing filled teeth index (DMFT) dan status obesitas sentral dinilai dengan waist hip ratio (WHR) yang merupakan rasio dari lingkar pinggang (waist circumference) dan lingkar pangggul (hip circumference). Data dianalisa menggunakan SPSS 17 dengan tingkat signifikansi p0,05. Terdapat korelasi antara WHR dan waist circumference (WC) dengan indeks DMFT (p=0,028, r= 0,201; p=0,025, r=0,204). Pada pemerikasaan indeks DMFT didapatkan persentase individu dengan pengalaman karies kategori sangat rendah 14,2% (n=17), kategori rendah 17,5% (n=21) kategori sedang 23,3% (n=28), kategori tinggi 29,1% (n=35) dan kategori sangat tinggi 15,8% (n=19). Pengukuran antropometri didapatkan rerata WC=78,6, hip circumference (HC)=97,3 dan WHR=0,81. Persentase individu yang mengalami obesitas sentral pada laki-laki sebesar 13,3% (n=8) dan pada perempuan 28,3% (n=17). Pada penelitian ini status obesitas sentral memiliki hubungan signifikan terhadap indeks DMFT.

Electroacupuncture Combined With Diet Treatment Has a Therapeutic Effect on Perimenopausal Patients With Abdominal Obesity by Improving the Community Structure of Intestinal Flora

Background: This study explored the influences of electroacupuncture combined with dietary intervention on the intestinal flora in perimenopausal patients with abdominal obesity by using the 16s rRNA sequencing technology.Methods: Perimenopausal patients with abdominal obesity were divided into the Electroacupuncture group and the Control group. Patients in the Control group received healthy lifestyle education, while those in the Electroacupuncture group received electroacupuncture combined with dietary intervention. Before and after treatment, the weight, height, waist circumference, hip circumference, waist-height ratio (WHtR), waist to hip ratio (WHR), and body mass index (BMI) of the patients were recorded; the levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL-C), fasting insulin (FINS), and fasting blood glucose (FGB) were evaluated; and the abundance, diversity, and species differences of intestinal flora were analyzed using 16s rRNA sequencing technology.Results: The body weight, waist circumference, hip circumference, BMI, WHR, and WHtR of patients in the Electroacupuncture group after treatment were lower than those before treatment. Compared with the Control group, patients in the Electroacupuncture group after treatment displayed lower waist circumference, WHtR, WHR, TG, and LDL levels as well as species abundance, higher species diversity, and lager species difference in the intestinal flora. Besides, the proportions of Klebsiella and Kosakonia in the intestinal flora of patients in the Electroacupuncture group after treatment were larger than those before treatment.Conclusion: Electroacupuncture combined with diet treatment generated a therapeutic effect on abdominal obesity in perimenopausal patients by improving the community structure of intestinal flora.

The effect of sports participation in obese boys on some obesity indicators and physical fitness parameters

Background. To examine the effects of sports participation in obese boys on body mass index (BMI), waist circumference, hip circumference, muscle strength, muscular endurance, balance and agility. Materials and methods. Sixty-three obese children with a mean age of 10.80 ± 0.58 were included in the study. Participants participated in sports, including judo, table tennis and basketball, for three months at their schools. Body weight, waist circumference and hip circumference of the participants were measured before and after participating in sports. Before and after participating in sports, grip strength, bent arm hanging, single-leg stance balance and plate tapping tests were applied to the participants. Results. While before participating in sports, BMI, waist and hip circumference outcomes of the participants were 23.04 ± 2.89 cm/m2, 81.61 ± 8.56 cm and 87.69 ± 6.52 cm, respectively; after participating in sports, BMI, waist circumference and hip circumference outcomes were 22.51 ± 2.88 cm/m2, 79.38 ± 8.74 cm and 85.73 ± 6.65 cm, respectively. The results of the single leg balance and bent arm-hanging tests after participation in sports increased compared to the results which before participating in sports (p < 0.05). However, the results of plate tapping test results that after participation in sports were less than the results which before participating in sports (p < 0.05). The result obtained from the grip strength after participation in sports was not different from the result obtained before participating in sports (p > 0.05). Conclusions. Participation in regular sports in obese children has positive effects on BMI, waist circumfe­rence and hip circumference, which are associated with chronic diseases. Additionally, the participation of obese children in regular sports contributes to the development of physical fitness parameters, which are indicators of health.

Relationship Between Physical Fitness, Anthropometric Measurement, and Bone Health in Adult Men

The aim of this study was to assess the relationship between physical fitness, anthropometric measurement, and bone health in adult men. Ninety-six adult men participated in this cross-sectional study. Anthropometric measures, including height, weight, chest, waist and hip circumference, and physical fitness parameters reflecting muscular strength, agility, flexibility, power, balance, and cardiopulmonary fitness were assessed. Whole-body bone mineral density (BMD) and bone mineral content (BMC) were measured with a dual-energy X-ray absorptiometry scanner. The results showed bone health outcomes to have a significant correlation with anthropometric and physical fitness parameters. Stepwise regression analysis proved physical fitness parameters explaining significant variance in bone health such as BMD and BMC to be focused on muscular strength, flexibility, and pulmonary function. Furthermore, anthropometric parameters including hip circumference can help explain BMC. The findings suggest that anthropometry and physical fitness can be used for the prediction of bone health in adult men.

Dietary habits and nutritional status in students of the university corporation Rafael Núñez, Cartagena-Colombia

Purpose This paper aims to determine the eating habits and physical activity in students of the Rafael Núñez University. Design/methodology/approach Descriptive cross-sectional study, based on the application of a survey on eating habits and physical activity. Furthermore, height, weight, hip circumference and abdominal circumference were also recorded. Findings Total, 170 students were included, 29 (17.1%) males and 141 (82.9%) females, with a mean age of 20.0 ± 5.2 years. Among the students, 22 (12.9%) were underweight, 95 (55.9%) were normal weight, 40 (23.5%) were overweight and 13 (7.7%) with obesity. Regarding eating habits, the majority preferred to consume three daily meals: breakfast 140 (82.3%), lunch 170 (100%) and dinner 96 (56.5%). Regarding fruits intake, 18 (15.9%) males reported consuming them seven days a week, and 54 (31.2 %) females reported consuming them occasionally. In physical activity, most of the population (n = 103, 60.6%) exercises with a frequency of one to three days/week. Originality/value The authors’ work is original and has not been sent to another magazine.

Educational differences in diabetes and diabetes self-management behaviours in WHO SAGE countries

Background Diabetes mellitus represents a substantial global health challenge, with prevalence rising in low- and middle-income countries (LMICs). Although diabetes is known to follow a socioeconomic gradient, patterns in LMICs are unclear. This study examined associations between education and diabetes, and diabetes self-management behaviours, in six LMICs. Methods Cross-sectional data for 31,780 participants from China, Ghana, India, Mexico, Russia, and South Africa from the World Health Organization Study on Global AGEing and adult health (SAGE) study were used. Participants aged ≥50 years completed face-to-face interviews between 2007 and 2010. Participants self-reported diabetes diagnosis, physical activity, sedentary time, fruit and vegetable consumption, any special diet/program for diabetes, whether they were taking insulin for diabetes and number of years of education. Height, weight, waist, and hip circumference were measured. Country-specific survey-weighted log-binomial regression models were fitted to examine associations between the number of years of education and self-reported diabetes diagnosis (primary analysis). In secondary analyses, among those with a self-reported diabetes diagnosis, generalised linear regression models were fitted to examine associations between education and i) physical activity, ii) sedentary time, iii) fruit and vegetable consumption, iv) special diet for diabetes, v) taking insulin, vi) BMI, vii) waist circumference and viii) hip circumference. Results There was strong evidence of an association between years of education and diabetes diagnosis in Ghana (RR = 1.09, 95% CI: 1.06–1.13) and India (RR = 1.09, 95% CI: 1.07–1.12) only. In India, greater years of education was associated with higher leisure physical activity, fruit and vegetable intake, rates following a special diet or taking insulin, but also higher mean BMI, waist and hip circumference. Relationships between education and self-management behaviours were rarely seen in the other countries. Conclusions Associations between education and diabetes, and behavioural self-management (India only) was more evident in the two least developed (Ghana and India) of the WHO SAGE countries, indicating increasing diabetes diagnosis with greater numbers of years of education. The lack of gradients elsewhere may reflect shifting risk from higher to lower educated populations. While there was some suggestion that self-management behaviours were greater with increased education in India, this was not observed in the other countries.

Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren

Background. The use of easily accessible biomarkers for assessing young patients’ health is weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of healthy school-age children and comparing subgroups according to age, sex, and stress perception. Material and Methods. 503 children under 12 years old ( 8.7 ± 1.3 ) were included with anthropometric evaluation (height, waist, hip circumference, body weight, and body mass index (BMI)). Levels of opiorphin (OPI), free cortisol, alpha-amylase (sAA), and secreted immunoglobulin (sIgA) were determined by quantitative assays (ELISA) in unstimulated saliva. Unpaired t -test, Welch test, and Mann–Whitney U test were applied for appropriate group comparisons, and the correlation between variables was analyzed with Spearman’s rank coefficient. Results were considered significant at p < 0.05 . Results. sIgA and sAA exhibited significant differences depending on age and sex: IgA (ng/mL): 86 ± 68.6 vs. 104.9 ± 72.1 for (6-7 y.o.) and (8-11 y.o.), respectively, and 108.1 ± 80.1 vs. 94.6 ± 62.2 for male and females, respectively; sAA (U/mL): 78.9 ± 54.4 vs. 100.5 ± 81.2 for (6-7 y.o.) and (8-11 y.o.). No difference related to age or sex between groups was observed for cortisol and OPI. However, OPI levels were higher and correlated to prior stress exposure in children ( 0.31 ± 0.4 vs. 0.26 ± 0.5 ng / mL , p = 0.031 ). sAA was negatively correlated to low mood self-declaration in children in the last two weeks ( r = − 0.10 , p = 0.045 ). Conclusions. sIgA and sAA can be used as sex- and age-related biomarkers in children 6-12 y.o., which is not the case for free cortisol and opiorphin. However, OPI reflected previous exposure to stress, suggesting its use for evaluating stress-related changes in children