Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K /Akt/ mTOR and NF‐κB signalling pathways

2020 ◽  
Author(s):  
Xing Lin ◽  
Yan Li ◽  
Xiaoling Zhang ◽  
Yuanyuan Wei ◽  
Shujuan Wen ◽  
...  
Keyword(s):  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Signalling Pathways ◽  
Tormentic Acid

scholarly journals Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells

2009 ◽  
Vol 2 (1) ◽  
Author(s):  
Alessandra Gentilini ◽  
Benedetta Lottini ◽  
Marco Brogi ◽  
Alessandra Caligiuri ◽  
Lorenzo Cosmi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Intracellular Signalling ◽  
Signalling Pathways ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Intracellular Signalling Pathways ◽  
Growth Factor I

Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: role of different intracellular signalling pathways

2002 ◽  
Vol 36 (2) ◽  
pp. 179-190 ◽  
Author(s):  
Antonio Di Sario ◽  
Emanuele Bendia ◽  
Gianluca Svegliati-Baroni ◽  
Marco Marzioni ◽  
Francesco Ridolfi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Intracellular Signalling ◽  
Platelet Derived Growth Factor ◽  
Signalling Pathways ◽  
Intracellular Signalling Pathways ◽  
Cytoskeletal Network

323 Beta 3 specific non-peptidic integrin antagonist EMD409915 inhibits hepatic stellate cells migration via P38 and FAK signalling pathways

2004 ◽  
Vol 40 ◽  
pp. 98-99
Author(s):  
E. Patsenker ◽  
Y. Popov ◽  
M. Wiesner ◽  
S.L. Goodman ◽  
D. Schuppan
Keyword(s):  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Signalling Pathways

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways

2014 ◽  
Vol 35 (4) ◽  
pp. 1222-1233 ◽  
Author(s):  
Jie Li ◽  
Xingxia Li ◽  
Weiheng Xu ◽  
Shaozhan Wang ◽  
Zhenlin Hu ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Signalling Pathways

scholarly journals Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells

2016 ◽  
Vol 36 (4) ◽  
Author(s):  
Tianhui Liu ◽  
Ping Wang ◽  
Min Cong ◽  
Dong Zhang ◽  
Lin Liu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Hepatic Stellate Cells ◽  
Molecular Mechanisms ◽  
Stellate Cells ◽  
Transcriptional Factor ◽  
Signalling Pathways ◽  
Akt Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Prevention And Treatment ◽  
Important Regulator

Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways. In the current study, we attempted to further explore the molecular mechanisms involved in the regulation of MMP-1. We treated a co-cultured system that included hepatocytes (C3A) and hepatic stellate cells (LX-2) with DDC. The data revealed that the transcriptional factor ETS-1, which is an important regulator of MMP-1, was up-regulated in LX-2 cells following DDC treatment. Furthermore, the up-regulation of MMP-1 by DDC has been abrogated through employing si-ETS-1 to block expression of ETS-1. We found that DDC significantly inhibited the expression of miR-222 in LX-2 cells. We transfected miR-222 mimic into LX-2 cells and then co-cultured the cells with C3A. The up-regulation of ETS-1 and MMP-1 in LX-2 cells treated with DDC were inhibited after miR-222 mimic transfection. These data indicate that DDC up-regulated MMP-1 in LX-2 cells through the miR-222/ETS-1 pathway. Finally, we treated the co-cultured system with an Akt inhibitor (T3830) and an ERK1/2 inhibitor (U0126). Both T3830 and U0126 blocked the suppression of miR-222 by DDC in LX-2. Collectively, these data indicate that DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways. Our study provides experimental data that will aid the control of the process of fibrolysis in liver fibrosis prevention and treatment.

scholarly journals Regulation of Fibrotic Processes in the Liver by ADAM Proteases

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1226 ◽  
Author(s):  
Dirk Schmidt-Arras ◽  
Stefan Rose-John
Keyword(s):  
Extracellular Matrix ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Present Review ◽  
Signalling Pathways ◽  
Receptor Interactions ◽  
The Future ◽  
Intercellular Signalling ◽  
Membrane Bound ◽  
Adam Family

Fibrosis in the liver is mainly associated with the activation of hepatic stellate cells (HSCs). Both activation and clearance of HSCs can be mediated by ligand–receptor interactions. Members of the a disintegrin and metalloprotease (ADAM) family are involved in the proteolytic release of membrane-bound ligands and receptor ectodomains and the remodelling of the extracellular matrix. ADAM proteases are therefore major regulators of intercellular signalling pathways. In the present review we discuss how ADAM proteases modulate pro- and anti-fibrotic processes and how ADAM proteases might be harnessed therapeutically in the future.

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