Stromal derived factor-1α in hippocampus radial glial cells in vitro regulates the migration of neural progenitor cells

2015 ◽  
Vol 39 (6) ◽  
pp. 750-758 ◽  
Author(s):  
Hui Ding ◽  
Guo-Hua Jin ◽  
Lin-Qing Zou ◽  
Xiao-Qing Zhang ◽  
Hao-Ming Li ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Glial Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Radial Glial Cells ◽  
Radial Glial

Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain

2014 ◽  
Vol 94 (3) ◽  
pp. 709-737 ◽  
Author(s):  
Leda Dimou ◽  
Magdalena Götz
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Glial Cells ◽  
Mammalian Brain ◽  
Radial Glial Cells ◽  
Glial Progenitors ◽  
Stem And Progenitor Cells ◽  
Radial Glial

The diverse functions of glial cells prompt the question to which extent specific subtypes may be devoted to a specific function. We discuss this by reviewing one of the most recently discovered roles of glial cells, their function as neural stem cells (NSCs) and progenitor cells. First we give an overview of glial stem and progenitor cells during development; these are the radial glial cells that act as NSCs and other glial progenitors, highlighting the distinction between the lineage of cells in vivo and their potential when exposed to a different environment, e.g., in vitro. We then proceed to the adult stage and discuss the glial cells that continue to act as NSCs across vertebrates and others that are more lineage-restricted, such as the adult NG2-glia, the most frequent progenitor type in the adult mammalian brain, that remain within the oligodendrocyte lineage. Upon certain injury conditions, a distinct subset of quiescent astrocytes reactivates proliferation and a larger potential, clearly demonstrating the concept of heterogeneity with distinct subtypes of, e.g., astrocytes or NG2-glia performing rather different roles after brain injury. These new insights not only highlight the importance of glial cells for brain repair but also their great potential in various aspects of regeneration.

In Vitro Expansion of a Multipotent Population of Human Neural Progenitor Cells

1999 ◽  
Vol 158 (2) ◽  
pp. 265-278 ◽  
Author(s):  
Melissa K. Carpenter ◽  
Xia Cui ◽  
Zhong-yi Hu ◽  
Jennifer Jackson ◽  
Sandy Sherman ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
In Vitro Expansion ◽  
Human Neural Progenitor Cells

Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro

2016 ◽  
Vol 91 (2) ◽  
pp. 827-837 ◽  
Author(s):  
Marta Barenys ◽  
Kathrin Gassmann ◽  
Christine Baksmeier ◽  
Sabrina Heinz ◽  
Ingrid Reverte ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Epigallocatechin Gallate ◽  
Neural Progenitor ◽  
And Migration

scholarly journals Temporal and epigenetic regulation of neurodevelopmental plasticity

2007 ◽  
Vol 363 (1489) ◽  
pp. 23-38 ◽  
Author(s):  
Nicholas D Allen
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Developmental Plasticity ◽  
Neural Progenitor Cells ◽  
Embryonic Stem ◽  
Neural Progenitor ◽  
Neural Progenitors ◽  
Developmental Potential ◽  
Neural Lineage

The anticipated therapeutic uses of neural stem cells depend on their ability to retain a certain level of developmental plasticity. In particular, cells must respond to developmental manipulations designed to specify precise neural fates. Studies in vivo and in vitro have shown that the developmental potential of neural progenitor cells changes and becomes progressively restricted with time. For in vitro cultured neural progenitors, it is those derived from embryonic stem cells that exhibit the greatest developmental potential. It is clear that both extrinsic and intrinsic mechanisms determine the developmental potential of neural progenitors and that epigenetic, or chromatin structural, changes regulate and coordinate hierarchical changes in fate-determining gene expression. Here, we review the temporal changes in developmental plasticity of neural progenitor cells and discuss the epigenetic mechanisms that underpin these changes. We propose that understanding the processes of epigenetic programming within the neural lineage is likely to lead to the development of more rationale strategies for cell reprogramming that may be used to expand the developmental potential of otherwise restricted progenitor populations.

Dehydroabietic acid cytotoxicity in goldfish radial glial cells in vitro

2016 ◽  
Vol 180 ◽  
pp. 78-83 ◽  
Author(s):  
Lei Xing ◽  
Juan Manuel Gutierrez-Villagomez ◽  
Dillon F. Da Fonte ◽  
Maddie J. Venables ◽  
Vance L. Trudeau
Keyword(s):  
Glial Cells ◽  
Dehydroabietic Acid ◽  
Radial Glial Cells ◽  
Radial Glial
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