Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

2021 ◽  
Author(s):  
Ishfaq Hassan Mir ◽  
Shreyoshi Guha ◽  
Jajnasenee Behera ◽  
Chinnasamy Thirunavukkarasu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signal Transduction ◽  
Cancer Therapy ◽  
Signal Transduction Pathways ◽  
Molecular Signal

Recent Progress and Development of Small Molecule Kinase Inhibitors for the Treatment of Breast Cancer

2020 ◽  
Vol 16 (1) ◽  
pp. 4-19 ◽  
Author(s):  
Debasis Das ◽  
Jian Hong
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Cancer Therapy ◽  
Recent Progress ◽  
Kinase Inhibitors ◽  
Signal Transduction Pathways ◽  
Targeted Drugs ◽  
Breast Cancer Therapy ◽  
Health Burden ◽  
Treat Breast Cancer

Breast cancer, the most common health burden to women globally, is considered a major cause of death for women every year. Many signal transduction pathways can cause breast cancer. The kinase inhibitors can interrupt the signaling pathways, minimize tumor growth and consequently cure the disease. The scientists have discovered many kinase inhibitors as targeted drugs for breast cancer. In recent years, the inhibitors of EGFR, HER2, VEGFR, PI3K, CDK4/6, PARP and hormone receptor have been studied well for curing breast cancer. The FDA has approved a few kinase drugs such as trastuzumab, lapatinib, neratinib, palbociclib, abemaciclib, alpelisib to treat breast cancer recently. In this review, we summarized the latest development of kinase inhibitors as breast cancer therapy.

Abstract 3563: Novel anticancer agents modulate multiple signal transduction pathways for cancer therapy

2010 ◽  
Author(s):  
Ling Jong ◽  
Wan-ru Chao ◽  
Yihui Shi ◽  
Carol Green ◽  
Lidia Sambucetti ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
Signal Transduction Pathways ◽  
Multiple Signal
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