Dissection of Signal Transduction Pathways as a Tool for the Development of Targeted Therapies of Hepatocellular Carcinoma

2007 ◽  
Vol 2 (3) ◽  
pp. 217-236 ◽  
Author(s):  
Diego Calvisi ◽  
Rosa Pascale ◽  
Francesco Feo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signal Transduction ◽  
Targeted Therapies ◽  
Signal Transduction Pathways

scholarly journals The significance of exosomes in the development and treatment of hepatocellular carcinoma

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Xin Li ◽  
Chuanyun Li ◽  
Liping Zhang ◽  
Min Wu ◽  
Ke Cao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signal Transduction ◽  
Liver Cancer ◽  
Early Diagnosis ◽  
Cancer Cells ◽  
Clinical Diagnosis ◽  
Diagnosis And Treatment ◽  
Signal Transduction Pathways ◽  
Liver Cancer Cells ◽  
Different Types

AbstractHepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC. Exosomes are small vesicular structures that mediate interaction between different types of cells, and contain a variety of components (including DNA, RNA, and proteins). Numerous studies have shown that these substances in exosomes are involved in growth, metastasis and angiogenesis in liver cancer, and then inhibited the growth of liver cancer by blocking the signaling pathway of liver cancer cells. In addition, the exosomal substances could also be used as markers for screening early liver cancer. In this review, we summarized to reveal the significance of exosomes in the occurrence, development, diagnosis and treatment of HCC, which in turn might help us to further elucidate the mechanism of exosomes in HCC, and promote the use of exosomes in the clinical diagnosis and treatment of HCC.

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