Differential expression of circular RNAs in plasma exosomes from patients with ankylosing spondylitis

2022 ◽  
Author(s):  
Lele Zhang ◽  
Liyan Qu ◽  
Yurong Zhang ◽  
Zhijiang Xu ◽  
Huqiang Tang
Keyword(s):  
Ankylosing Spondylitis ◽  
Differential Expression ◽  
Circular Rnas

The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation

2017 ◽  
Vol 74 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Zhiqiang Ye ◽  
Xuhui Liu ◽  
Yuewu Yang ◽  
Xianling Zhang ◽  
Ting Yu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Differential Expression ◽  
Rat Model ◽  
Smoke Inhalation ◽  
Circular Rnas

scholarly journals Differential expression profiles and functional analysis of circular RNAs in children with fulminant myocarditis

Epigenomics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1129-1141 ◽  
Author(s):  
Li Zhang ◽  
Bo Han ◽  
Jing Wang ◽  
Qingqing Liu ◽  
Yaru Kong ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Healthy Volunteers ◽  
Differential Expression ◽  
Expression Profiles ◽  
Interaction Network ◽  
Fulminant Myocarditis ◽  
Circular Rnas ◽  
Biological Functions ◽  
Microarray Experiments ◽  
Network Building

Aim: To assess differential expression profiles of circular RNAs (circRNAs) and explore their possible functions in children with fulminant myocarditis. Materials & methods: circRNA microarray experiments were carried out for determining differential expression profiles of circRNAs in three children with fulminant myocarditis and three healthy volunteers. Functional analysis and circRNA–miRNA–mRNA interaction network building were conducted to study biological functions. Results: This work identified 2281 upregulated and 892 downregulated circRNAs. Further assessment confirmed hsa_circ_0071542 upregulation (2.5-fold) in fulminant myocarditis. Functional analysis demonstrated the differentially expressed circRNAs mainly contributed to inflammation and immunity. Conclusion: circRNAs might have substantial roles in pediatric fulminant myocarditis, and hsa_circ_0071542 could serve as a promising biomarker.

scholarly journals Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Jianqiang Kou ◽  
Guoming Liu ◽  
Xiangyun Liu ◽  
Tianmi Li ◽  
Ying Wei ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Bioinformatics Analysis ◽  
Expression Profiles ◽  
Potential Functions ◽  
Serine Phosphorylation ◽  
Differentially Expressed ◽  
Circular Rnas ◽  
Human Immune System ◽  
Tissue Samples ◽  
Spinal Ligament

Recent studies have reported that circular RNAs (circRNAs) play a crucial regulatory role in a variety of human diseases. However, the roles of circRNAs in ankylosing spondylitis (AS) remain unclear. In this study, we conducted circRNA expression profiling of the spinal ligament tissues of patients with AS by RNA sequencing (RNA-seq) and analyzed the potential functions of differentially expressed circRNA by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to investigate the potential mechanisms associated with AS. The results showed that a total of 1,172 circRNAs were detected in the spinal ligament tissue samples, of which 123 circRNAs were significantly differentially expressed by a fold change≥1.5 and p value < 0.05. Among these, 57 circRNAs were upregulated, and 66 were downregulated. GO and KEGG analyses demonstrated that the differentially expressed circRNAs were mainly involved in the regulation of biological processes of peptidyl-serine phosphorylation and human immune system that may be related to AS. In addition, the circRNA/miRNA interaction networks were established to predict the potential roles of differentially expressed circRNAs by bioinformatics analysis. Taken together, these results revealed the expression profiles of circRNAs and the potential functions of the differentially expressed circRNAs in the spinal ligament tissue of patients with AS, which may provide new clues for understanding the mechanisms associated with AS, and proceed to identify novel potential molecular targets for the diagnoses and treatment of AS.

Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder

2020 ◽  
Vol 57 (5) ◽  
pp. 2301-2313 ◽  
Author(s):  
Silvia Gasparini ◽  
Giorgia Del Vecchio ◽  
Silvia Gioiosa ◽  
Tiziano Flati ◽  
Tiziana Castrignano ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Differential Expression ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Circular Rnas ◽  
Btbr Mouse

scholarly journals Accurate quantification of circular RNAs identifies extensive circular isoform switching events

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinyang Zhang ◽  
Shuai Chen ◽  
Jingwen Yang ◽  
Fangqing Zhao
Keyword(s):  
False Discovery Rate ◽  
Differential Expression ◽  
Expression Analysis ◽  
Differential Expression Analysis ◽  
Circular Rnas ◽  
Rna Seq ◽  
Rnase R ◽  
False Discovery ◽  
Rrna Depletion ◽  
Accurate Expression

AbstractDetection and quantification of circular RNAs (circRNAs) face several significant challenges, including high false discovery rate, uneven rRNA depletion and RNase R treatment efficiency, and underestimation of back-spliced junction reads. Here, we propose a novel algorithm, CIRIquant, for accurate circRNA quantification and differential expression analysis. By constructing pseudo-circular reference for re-alignment of RNA-seq reads and employing sophisticated statistical models to correct RNase R treatment biases, CIRIquant can provide more accurate expression values for circRNAs with significantly reduced false discovery rate. We further develop a one-stop differential expression analysis pipeline implementing two independent measures, which helps unveil the regulation of competitive splicing between circRNAs and their linear counterparts. We apply CIRIquant to RNA-seq datasets of hepatocellular carcinoma, and characterize two important groups of linear-circular switching and circular transcript usage switching events, which demonstrate the promising ability to explore extensive transcriptomic changes in liver tumorigenesis.

scholarly journals Differential expression study of circular RNAs in exosomes from serum and urine in patients with idiopathic membranous nephropathy

2019 ◽  
Vol 15 (3) ◽  
pp. 738-753 ◽  
Author(s):  
Hualin Ma ◽  
Ying Xu ◽  
Rongrong Zhang ◽  
Baochun Guo ◽  
Shuyan Zhang ◽  
...  
Keyword(s):  
Differential Expression ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Circular Rnas ◽  
Expression Study ◽  
Serum And Urine
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