scholarly journals Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology

ChemCatChem ◽  
2021 ◽  
Author(s):  
Hannes Westphal ◽  
Rico Warias ◽  
Holger Becker ◽  
Matthias Spanka ◽  
Daniele Ragno ◽  
...  
Keyword(s):  
Steady State ◽  
Lab On A Chip ◽  
Immobilized Catalysts ◽  
Chip Technology ◽  
Steady State Operation

scholarly journals Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology

ChemCatChem ◽  
2021 ◽  
Author(s):  
Hannes Westphal ◽  
Rico Warias ◽  
Holger Becker ◽  
Matthias Spanka ◽  
Daniele Ragno ◽  
...  
Keyword(s):  
Steady State ◽  
Lab On A Chip ◽  
Immobilized Catalysts ◽  
Chip Technology ◽  
Steady State Operation

scholarly journals Testing Lab-on-a-Chip Technology for Culturing Human Melanoma Cells under Simulated Microgravity

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 402
Author(s):  
Dawid Przystupski ◽  
Agata Górska ◽  
Olga Michel ◽  
Agnieszka Podwin ◽  
Patrycja Śniadek ◽  
...  
Keyword(s):  
Simulated Microgravity ◽  
Lab On A Chip ◽  
Human Keratinocytes ◽  
Melanoma Cells ◽  
Short Exposure ◽  
Biological Research ◽  
Cell Physiology ◽  
Caspase Activity ◽  
Chip Technology ◽  
Cells Cultured

The dynamic development of the space industry makes space flights more accessible and opens up new opportunities for biological research to better understand cell physiology under real microgravity. Whereas specialized studies in space remain out of our reach, preliminary experiments can be performed on Earth under simulated microgravity (sµg). Based on this concept, we used a 3D-clinostat (3D-C) to analyze the effect of short exposure to sµg on human keratinocytes HaCaT and melanoma cells A375 cultured on all-glass Lab-on-a-Chip (LOC). Our preliminary studies included viability evaluation, mitochondrial and caspase activity, and proliferation assay, enabling us to determine the effect of sµg on human cells. By comparing the results concerning cells cultured on LOCs and standard culture dishes, we were able to confirm the biocompatibility of all-glass LOCs and their potential application in microgravity research on selected human cell lines. Our studies revealed that HaCaT and A375 cells are susceptible to simulated microgravity; however, we observed an increased caspase activity and a decrease of proliferation in cancer cells cultured on LOCs in comparison to standard cell cultures. These results are an excellent basis to conduct further research on the possible application of LOCs systems in cancer research in space.

Profile control for steady-state operation

1998 ◽  
Vol 40 (8A) ◽  
pp. A251-A268 ◽  
Author(s):  
Xavier Litaudon
Keyword(s):  
Steady State ◽  
Steady State Operation ◽  
Profile Control

scholarly journals Steady state operation simulation of the Francis-99 turbine by means of advanced turbulence models

2017 ◽  
Vol 782 ◽  
pp. 012006
Author(s):  
A Gavrilov ◽  
A Dekterev ◽  
A Minakov ◽  
D Platonov ◽  
A Sentyabov
Keyword(s):  
Steady State ◽  
Turbulence Models ◽  
Steady State Operation

Fluid turbulence simulations of divertor heat load for ITER hybrid scenario using BOUT++

2021 ◽  
Author(s):  
Xueyun Wang ◽  
Xueqiao Xu ◽  
Philip B Snyder ◽  
Zeyu Li
Keyword(s):  
Heat Flux ◽  
Steady State ◽  
Energy Loss ◽  
Heat Load ◽  
Type I ◽  
Fluid Turbulence ◽  
Drift Model ◽  
Steady State Operation ◽  
Different Types ◽  
The One

Abstract The BOUT++ six-field turbulence code is used to simulate the ITER 11.5MA hybrid scenario and a brief comparison is made among ITER baseline, hybrid and steady-state operation (SSO) scenarios. Peeling-ballooning instabilities with different toroidal mode numbers dominate in different scenarios and consequently yield different types of ELMs. The energy loss fractions (ΔWped/Wped) caused by unmitigated ELMs in the baseline and hybrid scenarios are large (~2%) while the one in the SSO scenario is dramatically smaller (~1%), which are consistent with the features of type-I ELMs and grassy ELMs respectively. The intra ELM divertor heat flux width in the three scenarios given by the simulations is larger than the estimations for inter ELM phase based on Goldston’s heuristic drift model. The toroidal gap edge melting limit of tungsten monoblocks of divertor targets imposes constraints on ELM energy loss, giving that the ELM energy loss fraction should be smaller than 0.4%, 1.0%, and 1.2% for ITER baseline, hybrid and SSO scenarios, correspondingly. The simulation shows that only the SSO scenario with grassy ELMs may satisfy the constraint.

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